Urinary miRNA-377 and miRNA-216a as biomarkers of nephropathy and subclinical atherosclerotic risk in pediatric patients with type 1 diabetes

MicroRNA-377 Inhibits Atherosclerosis by Regulating Triglyceride Metabolism Through the DNA Methyltransferase 1 in Apolipoprotein E-Knockout Mice

“…A recent study demonstrated that miR-377 can be used as early biomarkers of nephropathy and subclinical atherosclerotic risk in pediatric patients with type I diabetes. 12 Here, we found that plasma miR-377 mRNA expression was significantly decreased in adult patients with hypertriglyceridemia. It was reported that miR-377 expression was repressed by a high-fat diet, indicating that miR-377 may regulate triglyceride metabolism and affect the development of atherosclerosis.…”

Urinary exosomes: Potential biomarkers for diabetic nephropathy

“…5 An interesting approach for therapeutic intervention in diabetes would be cell-specific delivery of these molecules. Urine is an attractive source of molecular markers for DN [6][7][8][9][10][11][12][13] (Table 1). Urine miRNA levels might be reflective of the intrinsic kidney tissue injury.…”

<p>MicroRNAs and Risk Factors for Diabetic Nephropathy in Egyptian Children and Adolescents with Type 1 Diabetes</p>

“…9 Moreover, expression of miRNA-377 has also been reported in the same study to be positively correlated with carotid intima thickness in diabetic patients which points to its possible contribution to the pathogenesis of microvascular and macrovascular complications of diabetes. 9 Similarly, Wang et al 23 reported that miRNA-377 was upregulated in DN, and explained that overexpression of miRNA-377 could target the inhibition of synthesis of some important mesangial cell proteins, this may dangerously lead to fibronectin accumulation, and might enhance oxidative stress in mesangial cells. Consequently, trials of inhibition of miRNA-377 expression have been initiated as a new approach to treatment of DN.…”

“…This is in concordance with previous research which found that urinary miR-216a was significantly lower in all children with type 1 diabetes and the lowest levels were among the albuminuric group. 9 Research showed that under diabetic conditions, miR-216a was upregulated, followed by the inhibition of Y box binding protein 1 which led to increased expression of TGF-β stimulated clone 22, eventually resulting in high production of COL1 alpha2 in MCs. 11 In the albuminuric group in this study, expression of miR-21 was positively correlated with urinary levels of cystatin c and negatively correlated with eGFR using cystatin c. miRNA-21 is a key player in the pathogenesis of diabetic nephropathy and has been found to be highly expressed in renal tissues of patients with DN.…”