Urinary Metabolites of Caffeic and Chlorogenic Acids

Booth, A. N.; Emerson, Oliver H.; Jones, Francis T.; DeEds, Floyd

doi:10.1016/s0021-9258(18)70592-9

Cited by 171 publications

(24 citation statements)

References 9 publications

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“…This must be considered a minimum value because the degradation of phenylpropanoic acids to benzoic acids will afford labeled acetate that would be included in biochemical pathways other than those resulting in carbon dioxide. At the dose levels employed in these experiments, it is apparent that benzoic acid derivatives, including m-hydroxyhippuric acids (Booth et al, 1957), are quantitatively the most significant metabolites of hesperetin-3-14C.…”

Section: Discussionmentioning

confidence: 94%

Synthesis and metabolic fate of hesperetin-3-14C

Honohan¹,

Hale²,

Brown³

et al. 1976

J. Agric. Food Chem.

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D-proline (0.20 g), the preferential crystallization of D isomer was carried out in the same manner as described above. By repeating these procedures, L and D isomers were successively obtained. Table V shows the results obtained by the successive resolution of N-n-butyryl-DL-proline.Optical Resolution of Other IV-Acyl-DL-proIines.jV-Acetyl-DL-proline, iV-chloroacetyl-DL-proline, and Nisobutyryl-DL-proline could also be resolved in the same manner as described above. Although AMsobutyryl-DL-proline could not be resolved under stirring, the resolution was successful only when crystallization was induced by inoculation and was continued slowly without stirring or scratching. Conditions and results for the Biological Sciences and Chemical Synthesis Laboratories, Dynapol, Palo Alto, California 94304.

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Section: Discussionmentioning

confidence: 94%

Synthesis and metabolic fate of hesperetin-3-14C

Honohan¹,

Hale²,

Brown³

et al. 1976

J. Agric. Food Chem.

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mentioning

confidence: 99%

Functional characteristics of starches from proso and foxtail millets

Lorenz¹,

Hinze²

1976

J. Agric. Food Chem.

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“…These kind of conjugations is a way of detoxifying the compound and increasing its polarity (52). Additional FA metabolites include mhydrophenylpropionic acid, feruloylglycine, dihydroferulic acid, vanillic acid, vaniloylglycine, feruloyl-sulfate and trans-feruloyl-4-O-β-D-glucuronide (43,53). The conjugation reaction for the formation of FA-sulfoglucuronide, FA-glucuronide and FAsulfate is carried out by the activities of sulfotransferases and UDP glucuronosyl transferases, while the intestinal mucosa and kidney may take part in this process.…”

Section: Pharmacokinetics Of Fa: Absorption Metabolism Distribution A...mentioning

confidence: 99%

“…Conjugation of FA may be dose dependent as very high doses of FA may saturate the conjugation enzymes, leading to accumulation of free FA in the plasma. Apart from conjugation, metabolic reactions include reduction of the double bond, demethylation, dehydroxylation of C3 or C4 (54,55), as well as methylation (53,56). The efflux of the conjugates is also transporter(s)-dependent (57).…”

Section: Pharmacokinetics Of Fa: Absorption Metabolism Distribution A...mentioning

confidence: 99%

Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties

2022

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Plant biomass is a magnificent renewable resource for phytochemicals that carry bioactive properties. Ferulic acid (FA) is a hydroxycinnamic acid that is found widespread in plant cell walls, mainly esterified to polysaccharides. It is well known of its strong antioxidant activity, together with numerous properties, such as antimicrobial, anti-inflammatory and neuroprotective effects. This review article provides insights into the potential for valorization of FA as a potent antiviral agent. Its pharmacokinetic properties (absorption, metabolism, distribution and excretion) and the proposed mechanisms that are purported to provide antiviral activity are presented. Novel strategies on extraction and derivatization routes, for enhancing even further the antiviral activity of FA and potentially favor its metabolism, distribution and residence time in the human body, are discussed. These routes may lead to novel high-added value biorefinery pathways to utilize plant biomass toward the production of nutraceuticals as functional foods with attractive bioactive properties, such as enhancing immunity toward viral infections.

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Urinary Metabolites of Caffeic and Chlorogenic Acids

Cited by 171 publications

References 9 publications

Synthesis and metabolic fate of hesperetin-3-14C

Synthesis and metabolic fate of hesperetin-3-14C

Functional characteristics of starches from proso and foxtail millets

Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties

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