Urinary metabolite of 1-(2,4,6-trichlorophenyl)-3,3-dimethyltriazene with an intact diazoamino structure

Stability of Solid Drugs: Degradation of Ergocalciferol (Vitamin D2) and Cholecalciferol (Vitamin D3) at High Humidities and Elevated Temperatures

“…Levodopa Potentiation-The levodopa potentiation model is a reflection of increased dopaminergic activity, and the method used was that described by Everett (8). Groups of unfasted male mice [TAC:(SW)fBr] were administered pargyline4 a t a dose of 40 mg/kg po (0.4% in 0.5% methylcellulose) 4 hr prior to the administration of graded doses of test drugs or methylcellulose only.…”

Towards an efficient prodrug of the alkylating metabolite monomethyltriazene: Synthesis and stability of N-acylamino acid derivatives of triazenes

“…These compounds suffer metabolic oxidation by cytochrome P450 enzymes to give hydroxymethyltriazenes 3, which, by loss of formaldehyde, generate the cytotoxic monomethyltriazenes 4 ( Figure 1) [7][8][9]. These are known alkylating agents, capable of methylating DNA and RNA [10,11].…”

Reactions of Substituted Arenediazonium Chlorides with Methylamine- Formaldehyde Premix Revisited: Reactivity and Transformations of Methylolamine Intermediates and Their Biological Significance

“…■ -f X < 4f 3a [8], the com pound is well suited for m echanistic chem ical studies. In this vein we thus coupled 2 ,4 ,6-trichlorobenzenediazonium chloride w ith m ethylam ine-form aldehyde m ixture but the reaction yielded no single pro d u ct b ut left a yellow viscous residue.…”

“…A lth o ugh triazenyl alkylolam ines have b ee n re g ard ed as tran sien t m olecular species, exp erim en tal evidence for th e ir stability has b een gradually surfac- [7][8][9], synthetic [9,10], and th e ra p eu tic [1 1 , 12] studies.…”