Stability of Solid Drugs: Degradation of Ergocalciferol (Vitamin D2) and Cholecalciferol (Vitamin D3) at High Humidities and Elevated Temperatures

Vitamins in Pharmaceutical Formulations

“…Cholecalciferol (Vitamin D)-The decomposition of ergocalciferol and cholecalciferol at 25 and 40' under dry, humid conditions was studied by Grady and Thakker (19). Ergocalciferol decomposed rapidly at both temperatures in dry air, leading to formation of products of higher polarity.…”

Vitamin D in cutaneous carcinogenesis

“…The disparities in these study results may be attributed to differences in sun exposure or other dietary intake of vitamin D in participants, or differences in the supplement’s stability, because D 2 and D 3 degrade differently with environmental exposures. 70 The Endocrine Society, along with the Canadian Society of Endocrinology and Metabolism and the National Osteoporosis Foundation, published a clinical practice guideline in 2011 titled “Evaluation, Treatment and Prevention of Vitamin D Deficiency.” The Endocrine Society Clinical Guidelines suggests either vitamin D 2 or vitamin D 3 for the treatment and prevention of vitamin D deficiency. 71 The committee also recommended screening of only those individuals who are at high risk for vitamin D deficiency, including patients with osteoporosis, older patients with a history of falls, patients with malabsorption syndrome, chronic renal or hepatic disease, granulomatous diseases (sarcoid), and individuals with darker skin pigmentation (black and Hispanic individuals), obese persons (those with a body mass index [BMI] of >30 kg/m 2 ), and those taking medications known to increase 25(OH)D metabolism, such as anticonvulsants, systemic glucocorticoids, ketoconazole, and HIV medications.…”

Vitamin Fortification of Fluid Milk

“…Vitamin D itself is susceptible to degradation by oxygen, heat, and light once freed from the protection of food matrix. Degradation products resulting from UV light reactions include lumisterol, tachysterol, isotachysterol, and suprasterols (Bouillon and others ; Grady and Thakker ). Other degradation products of vitamin D also include trans‐vitamin D (from oxidative reactions), pyrovitamin D, and isopyrovitamin D (from thermal reactions; Grady and Thakker ).…”