Urinary Metabolic Evaluations in Solitary and Recurrent Stone Forming Children

DeFoor, William; Minevich, Eugene; Jackson, Elizabeth; Reddy, Pramod; Clark, Curtis; Sheldon, Curtis A.; Asplin, John R.

doi:10.1016/j.juro.2008.01.151

Cited by 43 publications

(33 citation statements)

References 15 publications

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“…Studies also show that children have higher urinary SS CaP than adults (32) and that stoneforming children have higher SS CaOx than non-stoneforming children (39,40). In addition, recurrent pediatric SFs have higher calcium excretion when adjusted for creatinine excretion or body weight than solitary pediatric SFs, but this did not translate into significantly different SSs (40,41).…”

Section: Promoters Of Stone Formationmentioning

confidence: 99%

“…Urinary citrate levels are highest in young children and decrease into adulthood (32,33), but relative hypocitraturia is a common finding in pediatric nephrolithiasis (22,23,28,39,40,51,52). Hypocitraturia has also been shown to be a risk factor for recurrent stone disease in children (37,41). Treatment with oral citrate supplementation has been shown to reduce stone risk (53,54).…”

Section: Inhibitors Of Stone Formationmentioning

confidence: 99%

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An Update on the Changing Epidemiology and Metabolic Risk Factors in Pediatric Kidney Stone Disease

Sas¹

2011

Clinical Journal of the American Society of Nephrology

136

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SummaryNephrolithiasis in children is a painful and costly disease that may also have detrimental long-term effects on kidney function. Recent data provide evidence that the incidence of nephrolithiasis in children is rising. Children who are white, female, and adolescent seem to have the highest risk for forming symptomatic kidney stones. Although the reasons for the rising incidence and demographic discrepancies in pediatric nephrolithiasis are not yet clear, recent investigations into urine chemistry provide clues regarding predisposing metabolic risk factors. As more data emerge regarding epidemiologic and metabolic characteristics of pediatric kidney stone formers, we hope to gain a better understanding of the causes of kidney stone disease and, ultimately, provide better strategies for stone prevention in children.

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Section: Promoters Of Stone Formationmentioning

confidence: 99%

Section: Inhibitors Of Stone Formationmentioning

confidence: 99%

An Update on the Changing Epidemiology and Metabolic Risk Factors in Pediatric Kidney Stone Disease

Sas¹

2011

Clinical Journal of the American Society of Nephrology

136

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“…A osteoponina, a nefrocalcina e o citrato bloqueiam a adesão de cristais de oxalato de cálcio às células. Os níveis de citrato urinário se encontram muito reduzidos em pacientes com urolitíase, especialmente em casos recorrentes (DEFOOR et al, 2008).…”

Section: Inibidores Da Urolitíaseunclassified

“…Um dos principais fatores de predisposição à urolitíase por estruvita é a infecção urinária por bactérias produtoras de urease (NATH et al, 1984;RAILA et al, 2003;GATORIA et al, 2006;DEFOOR et al, 2008;KOEHLER et al, 2008;ULRICH et al, 2008;SYME, 2012;BECKNELL et al, 2013). Havendo esse tipo de infecção bacteriana, associada à presença de magnésio e fosfato urinários (naturais na urina canina), as chances de ocorrência de cálculos de estruvita são muito aumentadas.…”

Section: Fatores Envolvidos No Desenvolvimento De Urólitos Específicosunclassified

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Etiopatogenia Da Urolitíase Em Cães

Ariza¹

2015

Enciclopédia Biosfera

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RESUMOA urolitíase é comum na clínica de cães e os casos de recidivas são frequentes. Decorre do desenvolvimento de urólitos no trato urinário e pode levar a alterações graves, como obstruções do fluxo urinário. Diversos fatores, sejam hereditários, congênitos ou adquiridos, podem estar envolvidos no desenvolvimento dos cálculos urinários. Os urólitos que mais frequentemente acometem animais da espécie canina são aqueles formados de estruvita, oxalato de cálcio, urato, cistina, fosfato de cálcio, xantina e sílica. No entanto, cálculos urinários com outras composições como de 2,8-diidroxiadenina podem acometer menos frequentemente animais dessa espécie. O conhecimento dos mecanismos que ocasionam a formação e o desenvolvimento dos diferentes tipos de urólito permite a instauração de protocolos de tratamento específicos mais eficientes e que reduzam a possibilidade de ocorrência de recidivas. PALAVRAS-CHAVE: cálculo urinário, canino, patogenia ETIOPATHOGENESIS OF UROLITHIASIS IN DOGS ABSTRACTUrolithiasis are common in dogs and recurrences are frequent. This disease results from the development of uroliths in the urinary tract and may lead to important conditions, such as urinary flow obstructions. Many factors, hereditary, congenital or acquired may be involved in the development of urinary calculi. In dogs, the most common urolith compositions are struvite, calcium oxalate, urate, cystine, calcium phosphate, xanthine and silica. However, urinary calculi with different compositions, such as 2,8-dihydroxyadenine may less frequently affect these animals. Knowledge of the mechanisms involved in the formation and growth of each urolith type allow the establishment of specific treatment protocols that are more efficient and reduce the possibility of recurrences.

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Blood and Urinary Tests in Stone Formers

Semins

Matlaga

2010

Urinary Tract Stone Disease

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Urinary Metabolic Evaluations in Solitary and Recurrent Stone Forming Children

Cited by 43 publications

References 15 publications

An Update on the Changing Epidemiology and Metabolic Risk Factors in Pediatric Kidney Stone Disease

An Update on the Changing Epidemiology and Metabolic Risk Factors in Pediatric Kidney Stone Disease

Etiopatogenia Da Urolitíase Em Cães

Blood and Urinary Tests in Stone Formers

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