Urinary lithogenesis risk tests: Comparison of a commercial kit and a laboratory prototype test

Gráses, F.; Costa-Bauzà, Antònia; Prieto, Rafel M.; Arrabal, Miguel; Haro, Tomás de; Lancina, Juan A.; C, Barbuzano; Colom, S.; Riera, Joaquín; Perelló, Joan; Isern, Bernat; Sanchís, Pilar; Conte, Antonio Hernandez; Barragan, Fernando; Gomila, Isabel

doi:10.3109/00365599.2011.584551

Cited by 10 publications

(4 citation statements)

References 16 publications

(23 reference statements)

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“…We found that 47.5% of our subjects had high CaUCR using previously established criteria (Table 1). Previous studies demonstrated that nearly 100% of patients who met these criteria were stone-formers [16,17,18]. We also found that subjects who better adhered to the MedDiet had a significantly decreased CaUCR.…”

Section: Discussionsupporting

confidence: 66%

“…Ca, P and Mg were measured using inductively coupled plasma tandem atomic emission spectrometry (ICP-AES), Ur was determined using the uricase method, Ox was determined using the oxalate oxidase/peroxidase method (LTA, Milano, Italy), and Cit was determined using an enzymatic assay (Biosystems, Barcelona, Spain). Lithogenic urine was defined by a high calcium salt urinary crystallization risk (CaUCR) or a high uric acid urinary crystallization risk (UrUCR), in accordance with the criteria indicated in Table 1 [16,17,18,19].…”

Section: Methodsmentioning

confidence: 99%

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Association of Adherence to The Mediterranean Diet with Urinary Factors Favoring Renal Lithiasis: Cross-Sectional Study of Overweight Individuals with Metabolic Syndrome

et al. 2019

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Our purpose was to study the relationship of adherence to the Mediterranean diet (MedDiet) with urinary factors that favor the formation of renal calcium and uric acid stones in overweight and obese participants who had metabolic syndrome. This cross-sectional study examined 267 participants. A well-known MedDiet score (range 0–9) was calculated for each patient, and patients were then categorized has having low (≤3), medium (4–5), or high (≥6) adherence to the MedDiet. Baseline characteristics and urinary parameters were also analyzed. High calcium salt urinary crystallization risk (CaUCR) and high uric acid urinary crystallization risk (UrUCR) were calculated from urinary parameters using pre-defined criteria. More than half of patients with MedDiet scores ≤3 had high UrUCR (55.4%) and high CaUCR (53.8%). In contrast, fewer patients with high adherence (≥6) to the MedDiet had high UrUCR (41.2%) and high CaUCR (29.4%). Relative to those with low adherence, individuals with high adherence had a prevalence ratio (PR) of 0.77 for a high UrUCR (95% CI: 0.46–1.12; p for trend: 0.069) and a PR of 0.51 for a high CaUCR (95% CI: 0.26–0.87; p for trend: 0.012) after adjusting for age, sex, body mass index, type 2 diabetes, and total energy intake. Our findings indicate that greater adherence to the MedDiet was associated with a reduced CaUCR and a reduced UrUCR. This suggests that adequate dietary management using the MedDiet patterns may prevent or reduce the incidence and recurrence of calcium salt and uric acid renal stones.

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Section: Discussionsupporting

confidence: 66%

Section: Methodsmentioning

confidence: 99%

Association of Adherence to The Mediterranean Diet with Urinary Factors Favoring Renal Lithiasis: Cross-Sectional Study of Overweight Individuals with Metabolic Syndrome

et al. 2019

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“…Эта группа маркеров ЛА является самой многочисленной и наиболее успешной. Четыре представителя данной группы дошли до этапа клинического применения: • BONN-Risk, реализованный в аппарате Urolizer [65,66]; • ULR-тест, реализованный в лабораторном наборе NefroPlus [67]; • тест подавления агломерации оксалата кальция, применяемый в клинике Ochsner Renal Stone Clinic (Луизиана, США) [68,69]; • Литос-тест, применяемый в России [8,70].…”

Section: тесты индуцированной кристаллизации мочиunclassified

Markers of lithogenic activity in kidney stone disease

Alfimov

Shaderkina

Korolev

et al. 2023

Androl. genit. hir.

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Литогенный процесс развивается незаметно. Было предложено несколько маркеров для выявления активации литогенного процесса. В данном обзоре мы проанализировали опубликованные данные о принципах действия этих диагностических тестов и описали 6 групп маркеров литогенной активности: 1) концентрация в моче камнеобразующих и ингибирующих ионов, а также производные от них соотношения, индексы и степени перенасыщения камнеобразующими соединениями; 2) макромолекулы и другие молекулы-маркеры, определяемые в моче; 3) физические свойства мочи; 4) маркеры крови; 5) маркеры, определяемые инструментальными методами; 6) тесты индуцированной кристаллизации мочи. Самыми перспективными и наиболее успешными маркерами литогенной активности являются тесты индуцированной кристаллизации мочи, которые могут применяться для выявления периодов повышенной литогенной активности, что может дать возможность предотвратить камнеобразование за счет своевременного усиления терапии. Наличие доступного и удобного маркера литогенной активности, применяемого регулярно в системе дистанционного мониторинга, позволит реализовать персонализированную программу предотвращения рецидивов мочекаменной болезни.

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“…Several studies used these indexes, including the calcium/citrate ratio, the ion activity product of calcium oxalate (AP[CaOx]), and calcium phosphate (AP[CaP]), to compare stone-forming children and adults with healthy controls, and found significant differences [7, 9–11]. Furthermore, previous studies have shown cut off values for urinary solute concentrations that makes urine prone to crystallize in an in vitro model [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Effect of sample time on urinary lithogenic risk indexes in healthy and stone-forming adults and children

et al. 2018

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BackgroundThe diagnosis and follow-up of stone forming patients is usually performed by analysis of 24-h urine samples. However, crystallization risk varies throughout the day, being higher at night. The main objective of this study is to evaluate the urinary crystallization risk in adults and children by calculating risk indexes based on different collection periods.MethodsThe study included 149 adults (82 healthy and 67 stone-formers) and 108 children (87 healthy and 21 stone-formers). 24-h urine was collected, divided into 12-h daytime sample (8 am to 8 pm), and 12-h overnight sample (8 pm to 8 am next morning). Solute concentrations, the calcium to citrate ratio (Ca/Cit), and the ion activity product of calcium oxalate (AP[CaOx]) and calcium phosphate (AP[CaP]) were calculated in each 12-h sample and in overall 24-h urine. Assessments were also related to stone type.ResultsCa/Cit and AP(CaOx) were significantly higher in stone forming patients than in healthy subjects. The 12-h overnight samples had the highest values for both risk indexes, confirming a greater risk for crystallization at night. The AP(CaP) index was significantly higher in patients with pure hydroxyapatite stones than healthy controls, but was not significantly different between stone-formers overall and healthy controls.ConclusionsThe calculation of risk indexes is a simple method that clinicians can use to estimate crystallization risk. For this purpose, the use of 12-h overnight urine may be a reliable alternative to 24-h collections.

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Urinary lithogenesis risk tests: Comparison of a commercial kit and a laboratory prototype test

Abstract: The new commercial NefroPlus test offers fast and cheap evaluation of the overall risk of development of urinary calcium-containing calculi.

Cited by 10 publications

References 16 publications

Association of Adherence to The Mediterranean Diet with Urinary Factors Favoring Renal Lithiasis: Cross-Sectional Study of Overweight Individuals with Metabolic Syndrome

Association of Adherence to The Mediterranean Diet with Urinary Factors Favoring Renal Lithiasis: Cross-Sectional Study of Overweight Individuals with Metabolic Syndrome

Markers of lithogenic activity in kidney stone disease

Effect of sample time on urinary lithogenic risk indexes in healthy and stone-forming adults and children

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