Urinary Indoles in Schizophrenic and Psychoneurotic Patients After Administration of Tranylcypromine (Parnate) and Methionine or Tryptophan

Sprince, Hkrrkrt; Parker, Clarence M.; Jameson, Dorothy; Alexander, Fred

doi:10.1097/00005053-196309000-00005

Cited by 43 publications

(6 citation statements)

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“…Sprince et al (1963) could not detect any NMIs in the urine of patients they subjected to a methionine load. However, they considered the possibility that their negative findings were due to the use of too small a sample of urine.…”

Section: Loading Experiments and Nmismentioning

confidence: 82%

“…Bufotenine was also found in the urine of schizophrenics given a MAOI alone (Heller, 1966) or in conjunction with betaine , or cysteine (Spaide et al, 1968). However, other workers could not find bufotenine in the urine of schizophrenics (Rodnight, 1956;Sprince et al, 1963;Siegel, 1965;Nishimura and Gjessing, 1965;Kakimoto et al, 1967), or could find it only in medicated and not in unmedicated schizophrenics (Runge et al, 1966). On the other hand, other workers found bufotenine in schizophrenics but also in normals (Perry et al, 1966;Gross and Fransen, 1964;Faurbye and Pind, 1968), mental defectives (Tanimukai et al, 1967), and autistic children and their relatives .…”

Section: Measurements Of Mnis In Schizophreniamentioning

confidence: 99%

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A Review of Nicotinic Acid, N-Methylated Indoleamines and Schizophrenia

Luchins¹,

Ban

Lehmann

1978

Int Pharmacopsychiatry

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The hypothesis that endogenously formed, N-methylated metabolites of indoleamines may play a role in the pathogenesis of schizophrenia was reviewed. Although N-methylated indoleamines can be produced in vivo and have significant psychotomimetic effects, there is little evidence for a specific increase in the méthylation of indoleamines in schizophrenic patients. It was noted that even if the relationship between schizophrenia and N-methylated indoleamines had existed, nicotinic acid would not be an appropriate therapeutic agent.

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Section: Loading Experiments and Nmismentioning

confidence: 82%

Section: Measurements Of Mnis In Schizophreniamentioning

confidence: 99%

A Review of Nicotinic Acid, N-Methylated Indoleamines and Schizophrenia

Luchins¹,

Ban

Lehmann

1978

Int Pharmacopsychiatry

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“…Amberlite CG-120, CG-50; ethanol-acetone ppt 1963 Sprince et al [9] DMT, HDMT 24 hour urine pH 10, ethyl ether-butanone ext, evap, acetone 1963 Perry and Schroeder [10] HDMT 24-36 hour urine; ext vol 250-350 mg creatinine…”

Section: Historical Perspectivementioning

confidence: 99%

“…1963 Perry [8] HDMT; DMT 2-D paper chromatography, color reaction ND Rf and color (2-D) 1963 Sprince et al [9] DMT, HDMT 2-D paper chromatography, color reaction ND Rf and color (2-D) 1963 Perry and Schroeder [10] HDMT paper chromatography (3 systems) ND Rf and color (3 systems) 1965 Franzen and Gross [11] DMT, HDMT Fluorescence 2 ng/ml…”

Section: Ndmentioning

confidence: 99%

“…Amberlite CG-120, CG-50; ethanol-acetone ppt w/wo hydrolysis 1963 Brune et al [7] HDMT; DMT 24 hour urine pH 10, ethyl ether ext, evap, acetone 1963 Perry [8] HDMT; DMT 24 or 48 hour urine; ext vol 500 mg creatinine Amberlite CG-120, CG-50; ethanol-acetone ppt 1963 Sprince et al [9] DMT, HDMT 24 hour urine pH 10, ethyl ether-butanone ext, evap, acetone 1963 Perry and Schroeder [10] HDMT…”

mentioning

confidence: 99%

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A critical review of reports of endogenous psychedelic N, N‐dimethyltryptamines in humans: 1955–2010

Barker

McIlhenny

Strassman

2012

Drug Testing and Analysis

105

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Three indole alkaloids that possess differing degrees of psychotropic/psychedelic activity have been reported as endogenous substances in humans; N,N‐dimethyltryptamine (DMT), 5‐hydroxy‐DMT (bufotenine, HDMT), and 5‐methoxy‐DMT (MDMT). We have undertaken a critical review of 69 published studies reporting the detection or detection and quantitation of these compounds in human body fluids. In reviewing this literature, we address the methods applied and the criteria used in the determination of the presence of DMT, MDMT, and HDMT. The review provides a historical perspective of the research conducted from 1955 to 2010, summarizing the findings for the individual compounds in blood, urine, and/or cerebrospinal fluid. A critique of the data is offered that addresses the strengths and weaknesses of the methods and approaches to date. The review also discusses the shortcomings of the existing data in light of more recent findings and how these may be overcome. Suggestions for the future directions of endogenous psychedelics research are offered. Copyright © 2012 John Wiley & Sons, Ltd.

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