Urinary exosomes as a novel biomarker for evaluation of α‐lipoic acid's protective effect in early diabetic nephropathy

Sun, Han; Yao, Wei‐Feng; Tang, Yubin; Zhuang, Wenfang; Wu, Dan; Huang, Shan; Sheng, Huiming

doi:10.1002/jcla.22129

Cited by 36 publications

(34 citation statements)

References 19 publications

(36 reference statements)

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“…In the study by Sun et al (2017) [99] levels of urinary CD63-positive exosomes were found 236 increased at early stage of renal injury in 62 early diabetic nephropathic (DN) subjects [99].…”

mentioning

confidence: 43%

Insights into the Diagnostic Potential of Extracellular Vesicles and their miRNA Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular Complications

Marca

Fierabracci

2017

Preprint

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mentioning

confidence: 43%

Insights into the Diagnostic Potential of Extracellular Vesicles and their miRNA Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular Complications

Marca

Fierabracci

2017

Preprint

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“…In the study by Sun et al [77], levels of urinary CD63-positive exosomes were found increased at the early stage of renal injury in diabetic nephropathic subjects.…”

Section: Extracellular Vesicles As Clinical Biomarkers Therapeutic Tmentioning

confidence: 90%

Part One: Extracellular Vesicles as Valuable Players in Diabetic Cardiovascular Diseases

Gherghiceanu¹,

Alexandru²,

Magda³

et al. 2020

Extracellular Vesicles and Their Importance in Human Health

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Extracellular vesicles (EVs) are particles released in the extracellular space from all cell types in physiological and pathological conditions and emerge as a new way of cell-cell communication by transferring their biological contents into target cells. The levels and composition of circulating EVs differ from a normal condition to a pathological one, making them real circulating biomarkers. EVs have a very complex contribution in both health and disease, most likely in relationship between diabetes and cardiovascular disease. The involvement of EVs to the development of cardiovascular complications in diabetes remains an open discussion for therapists. Circulating EVs may offer a continuous access path to circulating information on the disease state and a new perspective in finding a correct diagnosis, in estimating a prognosis and also in applying an effective therapy. Besides their role as biomarkers and targets for therapy, EVs can be exploited as biological tools in influencing the different processes affected in diabetic cardiovascular diseases. This chapter will summarize the current knowledge about EVs as biological vectors modulating diabetic cardiovascular diseases, including atherosclerosis, coronary artery disease, and peripheral arterial disease. Finally, we will point out EVs' considerable value as clinical biomarkers, therapeutic targets, and potential biomedical tools for the discovery of effective therapy in diabetic cardiovascular diseases.

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“…Sun et al . [ 82 ] reported that CD63-positive exosome levels were significantly higher in patients with normoalbuminuria than patients with microalbuminuria and only decreased markedly after therapy with alpha-lipoic acid (α-LA). Therefore, CD63-positive exosomes might also be used as a potential therapeutic indicator for DKD.…”

Section: R Oles Of U Rinary E mentioning

confidence: 99%

Urinary Extracellular Vesicle

Liu

et al. 2018

Chinese Medical Journal

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Objective:Diabetic kidney disease (DKD) has become one of the major causes of end-stage renal disease. Urinary extracellular vesicles (uEVs) contain rich biological information which could be the ideal source for noninvasive biomarkers of DKD. This review discussed the potential early diagnostic and therapeutic values of proteins and microRNAs in uEVs in DKD.Data Sources:This review was based articles published in PubMed, Embase, Cochrane, and Google Scholar databases up to November 20, 2017, with the following keywords: “Diabetic kidney disease”, “Extracellular vesicle”, and “Urine”.Study Selection:Relevant articles were carefully reviewed, with no exclusions applied to the study design and publication type.Results:There is no “gold standard” technology to separate and/or purify uEVs. The uEVs contain a variety of proteins and RNAs and participate in the physiological and pathological processes of the kidney. UEVs, especially urinary exosomes, may be useful biomarkers for early diagnosis and treatment to DKD. Furthermore, the uEVs has been used as a therapeutic target for DKD.Conclusion:Proteins and nucleic acids in uEVs represent promising biomarker for the diagnosis and treatment of DKD.

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Urinary exosomes as a novel biomarker for evaluation of α‐lipoic acid's protective effect in early diabetic nephropathy

Abstract: In summary, we emphasize short-term α-LA could protect the kidney in the early DN against general oxidative stress, particularly the urinary CD63-positive exosome could be a potential sensitive and therapeutic indicator.

Cited by 36 publications

References 19 publications

Insights into the Diagnostic Potential of Extracellular Vesicles and their miRNA Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular Complications

Insights into the Diagnostic Potential of Extracellular Vesicles and their miRNA Signature from Liquid Biopsy as Early Biomarkers of Diabetic Micro/Macrovascular Complications

Part One: Extracellular Vesicles as Valuable Players in Diabetic Cardiovascular Diseases

Urinary Extracellular Vesicle

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