Urinary Excretion of Magnesium in Man Following the Ingestion of Ethanol

McCollister, Robert J.; Flink, Edmund B.; Lewis, Mary D.

doi:10.1093/ajcn/12.6.415

Cited by 69 publications

(10 citation statements)

References 18 publications

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“…Since the early 1960s it has been recognized that alcoholism may cause severe hypomagnesemia (224,336). Patients suffer from unexplained renal Mg 2ϩ wasting, but may also have reduced intestinal Mg 2ϩ absorption due to vomiting or diarrhea.…”

Section: General Causes Of Hypomagnesemiamentioning

confidence: 99%

Magnesium in Man: Implications for Health and Disease

Baaij

Hoenderop

Bindels

2015

Physiological Reviews

1,238

1,299

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Section: General Causes Of Hypomagnesemiamentioning

confidence: 99%

Magnesium in Man: Implications for Health and Disease

Baaij

Hoenderop

Bindels

2015

Physiological Reviews

1,238

1,299

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“…1, and some patients show no increase at all [7][8][9]. The reasons for this wide individual variation are not com pletely understood, but one factor appears to be the mag nitude of the body stores of Mg.…”

Section: Acute Effects Of Alcohol Administrationmentioning

confidence: 99%

“…Alcohol, as noted above, is a potent diuretic for Mg acting to increase its urinary excretion several fold over baseline levels in most patients [1][2][3][4][5][6][7][8]. Assuming no compensatory increase in dietary intake or in the fraction of dietary Mg that is absorbed by the intestine, a negative balance of Mg would result, leading eventually to diminished body stores.…”

Section: Evidence For Magnesium Deficiencymentioning

confidence: 99%

Magnesium deficiency and alcohol intake: mechanisms, clinical significance and possible relation to cancer development (a review).

Rivlin

1994

Journal of the American College of Nutrition

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A comprehensive and critical review of the evidence relating magnesium (Mg) deficiency to alcohol consumption reveals several important types of interactions. First, alcohol acts acutely as a Mg diuretic, causing a prompt, vigorous increase in the urinary excretion of this metal along with that of certain other electrolytes. Second, with chronic intake of alcohol and development of alcoholism, the body stores of Mg become depleted. During the late stages of alcoholism, the urinary excretion of Mg may become diminished as a physiological response to reduced intake and reduction of body stores. A number of aspects of the clinical syndrome of alcoholism contribute to and intensify that already existing reduction in body Mg stores. Third, a number of manifestations of alcoholism are believed due to effects of Mg deficiency, and some therapeutic benefit has been suggested from treatment of alcoholic patients with Mg. Finally, relatively little attention has been paid to the possible value of Mg administration as a preventive measure to forestall or minimize the deleterious effects of chronic use of alcohol or to prevent the development of cancer than can occur in this setting.

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“…These data clearly indicate that a positive Mg balance occurs from ingested food in a period usually of 6 abstract form and not until 1963 that it was finally published. Acute administration of large doses of alcohol produces Mg diuresis [21,22]. It is quite clear that patients with severe alcoholism do not eat well, and, since half of their calories are from alcohol, they have inadequate intake of Mg as well as other nutrients.…”

Section: There Was the Need To Establish If Possible The Magnitude mentioning

confidence: 99%

Magnesium deficiency in human subjects—a personal historical perspective.

Flink¹

1985

Journal of the American College of Nutrition

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Over the past 30 years human magnesium (Mg) deficiency has become an accepted fact in most medical circles. Our index patient had striking neurological manifestations including generalized tremulousness, grimaces and fibrillary twitches of facial muscles, athetoid and choreiform movements of upper extremities, dysphagia, inability to speak, repeated convulsions, and confusion. She had received glucose in water and saline intravenously for several months. A patient with chronic alcoholism was noted to have almost identical symptoms and signs as the index patient. He also responded dramatically to MgSO4 injections. This resulted in a series of studies on patients with chronic alcoholism. The evidence of Mg deficiency in alcoholism includes the following: significant hypomagnesemia, strongly positive Mg balance during recovery, significant decrease in muscle Mg, a deficit of total exchangeable 28Mg quantitatively similar to deficit by balance studies, often a dramatic response of symptoms to therapy with Mg, and diuresis of Mg produced by ingestion of alcohol. Lipolysis with high levels of long-chain free fatty acids (FFA) occurs in withdrawal of alcohol in chronic alcoholism, withdrawal of certain addictive drugs, after trauma, surgery, administration of adrenergic compounds or theophylline, exposure to cold, and an adverse environment as in grass staggers. Concentrations of Mg fall when FFA increase in all of the above circumstances. This phenomenon has wide implications in health and disease. Better awareness of Mg deficiency in a wide variety of clinical conditions will result in life-saving treatment and less morbidity of other patients.

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Urinary Excretion of Magnesium in Man Following the Ingestion of Ethanol

Cited by 69 publications

References 18 publications

Magnesium in Man: Implications for Health and Disease

Magnesium in Man: Implications for Health and Disease

Magnesium deficiency and alcohol intake: mechanisms, clinical significance and possible relation to cancer development (a review).

Magnesium deficiency in human subjects—a personal historical perspective.

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