Urinary Epitectin (MUC-1 Glycoprotein) in the Menstrual Cycle and Interstitial Cystitis

Erickson, Deborah; Mast, Stuart; Ordille, Sarah; Bhavanandan, V. P.

doi:10.1016/s0022-5347(01)65667-2

Cited by 17 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This observation indicating the presence of galectins was further substantiated by the isolation of a 30-kDa protein by af nity chromatography of rabbit bladder extracts on immobilized lactose (4). Finally, the polymerase chain reaction (PCR) 2 was used to show the expression of both galectin-3 and galectin-4 in rabbit epithelium (unpublished data). Galectins are a family of animal lectins that ful ll two criteria: af nity for b -galactoside sugars, and shared characteristic amino acid sequences (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 89%

See 1 more Smart Citation

Signature Sequences for the Galectin‐4 Subfamily

et al. 1999

View full text Add to dashboard Cite

SummaryGalectins are a distinct family of animal lectins that have a cation-independent af nity for¯-galactoside sugars and share characteristic amino acid sequences. The cDNA encoding rabbit bladder galectin-4 has been cloned and sequenced (GenBank accession no. AF091738). The deduced 328 amino acid sequence predicts a multidomain structure consisting of an N-terminal peptide (19 residues) and two carbohydrate recognition domains (130 residues each) connected by a linker region (49 residues). Comparison of rabbit galectin-4 with related proteins reveals that two peptide motifs, M-A-F/Y-V-P-A-P-G-Y-Q-P-T-Y-N-P-T-L-P-Y in the N terminus and A-F-H-F-N-P-R-F-D-G-W-D-K-V-V-F in

show abstract

Section: Introductionmentioning

confidence: 89%

“…We are investigating the role of bladder epithelial glycoconjugates in bladder disorders such as interstitial cystitis (1)(2)(3). In continuation of these studies, histochemical examination of rabbit and human bladder sections revealed strong calcium-independent binding of b -Dgalactose neoglycoconjugates (4).…”

Section: Introductionmentioning

confidence: 99%