Cystite interstitielle et syndrome urétral

Deval, B.; Haab, F.

doi:10.1007/2-287-27807-9_38

Cited by 2 publications

(2 citation statements)

References 40 publications

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“…ASIC channels are primarily expressed in central (ASIC1a, -2a, 2b and -4) and peripheral neurons including nociceptors (ASIC1-3) where they participate in neuronal sensitivity to acidosis. They have also been detected in taste receptor cells (ASIC1-3)), photoreceptors and retinal cells (ASIC1-3), cochlear hair cells (ASIC1b), testis (hASIC3), pituitary gland (ASIC4), lung epithelial cells (ASIC1a and -3), urothelial cells, adipose cells (ASIC3), vascular smooth muscle cells (ASIC1-3), immune cells (ASIC1,-3 and -4) and bone (ASIC1-3) (ASIC distribution is well reviewed in [235,617]). A neurotransmitter-like function of protons has been suggested, involving postsynaptically located ASICs of the CNS in functions such as learning and fear perception [264,558,1233], responses to focal ischemia [1170] and to axonal degeneration in autoimmune inflammation in a mouse model of multiple sclerosis [322], as well as seizures [1234] and pain [99,236,237,249,1147].…”

Section: -Ht 3 Receptorsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Alexander

Mathie

Peters

et al. 2021

British J Pharmacology

203

167

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The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15539. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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Section: -Ht 3 Receptorsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Alexander

Mathie

Peters

et al. 2021

British J Pharmacology

203

167

View full text Add to dashboard Cite

show abstract

“…La douleur lors du remplissage de la vessie et son soulagement par la miction, l'existence de douleurs sus-pubiennes, pelviennes, uré-thrales, vaginales ou périnéales, la constatation d'hémor-ragie sous-muqueuse (glomérulations) lors de la cystoscopie avec hydrodistension, la présence d'un défaut de compliance vésicale lors de la cystodynanométrie sont d'autres critères positifs pour porter un diagnostic de cystite interstitielle [18]. Les critères diagnostiques de O'Leary et al [60], l'échelle de score de l'université du Wisconsin, le Pain Urgency Frequency score, le test de provocation au KCl [66], certains marqueurs urinaires [38,40,51] permettent aussi de préciser le diagnostic.…”

Section: Douleurs Vé Sicales (Painful Bladder Syndrome)unclassified

Physiopathologie des douleurs pelvi-périnéales

Watier¹,

Labat

Robert

et al. 2007

Douleur analg.

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La physiopathologie des douleurs pelvi-périnéa-les est complexe. Sa compréhension nécessite des compé-tences anatomiques et neurophysiologiques dans ce domaine. Il faut cesser de raisonner en termes d'organe, mais plutôt s'attarder à comprendre et à conceptualiser les mécanismes à la base de la genèse et de la régulation de la douleur au niveau local, régional, spinal et central. Parmi les syndromes les plus souvent rencontrés, on retrouve la cystite interstitielle, les différents types de douleurs vulvaires, la douleur pelvienne chez l'homme, les douleurs musculosquelettiques, le syndrome du releveur et la proctalgia fugax. On ne saurait passer sous silence le syndrome du côlon irritable (SCI), souvent apparenté à ces pathologies et cité lors de l'anamnèse. Toutes ces douleurs ont en commun une hypersensibilisation périphérique, voire centrale comme conséquence d'un bombardement chronique surtout nociceptif. Les hypothèses de travail, pour expliquer ces douleurs, appellent des facteurs inflammatoires, immunologiques, génétiques, neurologiques, neuro-endocriniens et psychologiques, alors que l'étiologie est le plus souvent inconnue.Abstract: The pathophysiology of pelvic and perineal pain is complex and misunderstood. Knowledge of the pelvic floor anatomy and comprehension of the neurophysiological aspects of pain are necessary. An organ-specific approach must be replaced by an understanding of the mechanisms of pain control at the local, regional and central levels. Interstitial cystitis, vulvar pain, chronic pelvic pain in men, musculoskeletal pain, levator ani syndrome and proctalgia fugax are the most frequent pelvic and perineal pain syndromes encountered in clinical practice. Irritable bowel syndrome is often associated with these syndromes and should be considered as a pelvic-perineal pain syndrome. Peripheral and central hypersensitisation resulting from chronic nociceptive stimulation seems to be the common link between these clinical syndromes. Inflammatory, immunological, genetic, neurological, neuroendocrine and psychological factors have been implicated in the aetiology of chronic pelvic-perineal pain.

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Cystite interstitielle et syndrome urétral

Cited by 2 publications

References 40 publications

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Physiopathologie des douleurs pelvi-périnéales

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