Urinary Epidermal Growth Factor Levels in Patients With Acute Renal Failure

Taira, Takayasu; Yoshimura, Akinobu; lizuka, Kazuhide; Iwasaki, Shigeki; Ideura, Terukuni; Koshikawa, Shozo

doi:10.1016/s0272-6386(12)80427-6

Cited by 23 publications

(22 citation statements)

References 25 publications

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“…Increased urine NGAL has been associated with acute kidney injury, 51,56,57 but we found levels to be decreased in preeclampsia. EGF has been shown to be decreased in acute renal failure, obstructive nephropathy, and diabetic nephropathy, 29,58,59 and we also found decreased urinary levels in preeclampsia. However, decreased excretion of both NGAL and EGF in preeclampsia was independent of complement components and may be influenced by alternative pathways of disease.…”

Section: Discussionsupporting

confidence: 70%

Complement Activation and Kidney Injury Molecule-1–Associated Proximal Tubule Injury in Severe Preeclampsia

et al. 2014

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We enrolled 25 cases with severe preeclampsia, 25 controls with chronic hypertension, and 25 healthy controls without hypertension from a cohort of women receiving care at Brigham and Women's Hospital from March 2012 through March 2013. Institutional review board approval was obtained through the Partners Human Research Committee, and subjects gave informed consent. All procedures followed were in accordance with institutional guidelines. Methods Abstract-Kidney injury with proteinuria is a characteristic feature of preeclampsia, yet the nature of injury in specific regions of the nephron is incompletely understood. Our study aimed to use existing urinary biomarkers to describe the pattern of kidney injury and proteinuria in pregnancies affected by severe preeclampsia. We performed a case-control study of pregnant women from Brigham and Women's Hospital from 2012 to 2013. We matched cases of severe preeclampsia (n=25) 1:1 by parity and gestational age to 2 control groups with and without chronic hypertension. Urinary levels of kidney injury molecule-1 and complement components (C3a, C5a, and C5b-9) were measured by enzyme-linked immunosorbent assay, and other markers (albumin, β2 microglobulin, cystatin C, epithelial growth factor, neutrophil gelatinase-associated lipocalin, osteopontin, and uromodulin) were measured simultaneously with a multiplex electrochemiluminescence assay. Median values between groups were compared with the Wilcoxon signed-rank test and correlations with Spearman correlation coefficient. Analysis of urinary markers revealed higher excretion of albumin and kidney injury molecule-1 and lower excretion of neutrophil gelatinase-associated lipocalin and epithelial growth factor in severe preeclampsia compared with chronic hypertension and healthy controls. Among subjects with severe preeclampsia, urinary excretion of complement activation products correlated most closely with kidney injury molecule-1, a specific marker of proximal tubule injury (C5a: r=0.60; P=0.001; and C5b-9: r=0.75; P<0.0001). Taken together, we describe a pattern of kidney injury in severe preeclampsia that is characterized by glomerular impairment and complement-mediated inflammation and injury, possibly localized to the proximal tubule in

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Section: Discussionsupporting

confidence: 70%

Complement Activation and Kidney Injury Molecule-1–Associated Proximal Tubule Injury in Severe Preeclampsia

et al. 2014

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“…Moreover, in 6 out of the 11 sera collected 24h after phlebotomy, the measured sEGF levels were very low, below the 10% of the levels in the corresponding sera separated 4h after venipuncture, while in the five remaining samples, the measured values ranged between 16% and 36% of the corresponding levels at 4h. On the other hand, the mean sEGF value obtained at 1h for the whole population (n=105, 52 women, 53 men, 18-78 years, (Table 2), was within the range described in Taira´s report (300 pg/mL ± 30 pg/mL, n=12, seven men, five women, 24-79 years) [4]. Although the collection time of the sera is not declared in this communication, it seems to be an important variable to consider, as we just verified.…”

Section: Pattern Of Egf Serum Levelssupporting

confidence: 81%

“…In either case, this factor is later released into serum during the coagulation process. To our knowledge, there are few published reports about sEGF levels in healthy human donors [3][4][5][6]. In a significant part of them, the time of sera separation is either not declared or properly controlled [3], or it varies widely [5], thus affecting the reported sEGF values.…”

Section: Introductionmentioning

confidence: 99%

Measurement of Serum EGF Levels, a Methodological Approach: Learning What Means “Low-/High-Concentration of EGF In Serum”. Some Clinical Implications

Idania¹,

Hassiul²,

Adriana³

et al. 2017

J Mol Biomark Diagn

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“…[41][42][43][44] Este peptídeo é sintetizado quase exclusivamente dentro do rim, e sua concentração se reduz dramaticamente em pacientes com insuficiência renal aguda. 45 Paolo et al 46 avaliaram níveis urinários e a expressão em biópsia renal de EGF e IL-6 em 29 pacientes transplantados renais, aos 7 e 21 dias de transplante, e antes do tratamento de rejeição. Três transplantados renais com função renal estável e 10 amostras de tecidos viáveis de rins com carcinoma foram usados como controle.…”

Section: Citocinas E Quimiocinas No Tecido Renal E No Sangue De Transunclassified

Citocinas e quimiocinas no transplante renal

et al. 2009

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Urinary Epidermal Growth Factor Levels in Patients With Acute Renal Failure

Cited by 23 publications

References 25 publications

Complement Activation and Kidney Injury Molecule-1–Associated Proximal Tubule Injury in Severe Preeclampsia

Complement Activation and Kidney Injury Molecule-1–Associated Proximal Tubule Injury in Severe Preeclampsia

Measurement of Serum EGF Levels, a Methodological Approach: Learning What Means “Low-/High-Concentration of EGF In Serum”. Some Clinical Implications

Citocinas e quimiocinas no transplante renal

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