Urinary Cell-Free DNA IQGAP3/BMP4 Ratio as a Prognostic Marker for Non–Muscle-Invasive Bladder Cancer

Xu, Yanjie; Kim, Ye-Hwan; Jeong, Pildu; Piao, Xuan‐Mei; Byun, Young Joon; Seo, Sung Pil; Kang, Ho Won; Kim, Dong-Won; Lee, Jong‐Young; Ryu, Dong Hee; Choi, Jee Woong; Kim, Isaac Y.; Moon, Sung‐Kwon; Choi, Yung Hyun; Yun, Seok Joong; Kim, Wun-Jae

doi:10.1016/j.clgc.2019.04.001

Cited by 14 publications

(13 citation statements)

References 28 publications

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“…Their results showed that IQGAP3/BMP4 overexpression was observed in higher-stage and higher-grade diseases with high risks of recurrence and progression, whereas IQGAP3/FAM107A overexpression was associated with larger tumor size and disease progression. High IQGAP3/BMP4 ratio was significantly associated with worse recurrence-free survival (RFS); high IQGAP3/BMP4 and high IQGAP3/FAM107A ratios were both significantly associated with worse PFS [33]. The authors also found that MIBC patients had significantly higher ratios than NMIBC patients, suggesting that these ucfDNA biomarkers were associated with disease recurrence and progression.…”

Section: Urinary Cell-free Dna Expressionmentioning

confidence: 93%

“…As the measurement of two expressed genes were performed, the authors suggested that internal controls were not necessary. As a result, the ratios might be an accurate predictive biomarker in ucfDNA for bladder cancer detection and prognosis with maximum discriminatory ability [33].…”

Section: Urinary Cell-free Dna Expressionmentioning

confidence: 99%

“…Therefore, external validation becomes particularly important. Ongoing recruitment of bladder cancer patients with long-term follow up is crucial [10][11][12]23,33]. A better understanding of these biomarkers with stratification to different stages of bladder cancer and its relation to high-risk features such as carcinoma-in-situ is warranted.…”

Section: Limitationsmentioning

confidence: 99%

“…Last but not least, the evidence on the utility of ucfDNA for guiding subsequent treatment choices and predicting prognosis is very limited [33]. Future development of ucfDNA as a reliable pretreatment biomarker is especially important as novel agents, such as immune check point inhibitors, come into place.…”

Section: Limitationsmentioning

confidence: 99%

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Urinary Cell-Free DNA in Bladder Cancer Detection

et al. 2021

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Urinary bladder cancer is a common urological cancer. Although flexible cystoscopy is widely employed in bladder cancer detection, it is expensive, invasive, and uncomfortable to the patients. Recently, urinary cell-free DNA (ucfDNA) isolated from urine supernatant has been shown to have great potential in bladder cancer detection and surveillance. Molecular features, such as integrity and concentration of ucfDNA, have been shown to be useful for differentiating bladder cancer patients from healthy controls. Besides, bladder cancer also exhibits unique genetic features that can be identified from sequencing and expression of ucfDNA. Apart from bladder cancer detection, ucfDNA is also useful for molecular classification. For example, ucfDNA exhibits significant differences, both molecularly and genetically, in non-muscle-invasive and muscle-invasive bladder cancers. There is no doubt that ucfDNA is a very promising tool for future applications in the field of bladder cancer.

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Section: Urinary Cell-free Dna Expressionmentioning

confidence: 93%

Section: Urinary Cell-free Dna Expressionmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

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Urinary Cell-Free DNA in Bladder Cancer Detection

et al. 2021

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“…After validating their results in an independent cohort of patients, they concluded that the ratios IQGAP3/BMP4 and IQGAP3/FAM107A were both significantly increased in urine cfDNA from BC patients compare to patients with hematuria. Next, they evidenced that the ratio IQGAP3/BMP4 in urine cfDNA from NMIBC patients was associated with worse recurrence-free and progression-free survival [61].…”

Section: Analysis Of Gene Expressionmentioning

confidence: 99%

Circulating Cell-Free DNA in Liquid Biopsies as Potential Biomarker for Bladder Cancer: A Systematic Review

Herranz

Oto

Plana

et al. 2021

Cancers

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Bladder cancer (BC) is among the most frequent cancer types in the world and is the most lethal urological malignancy. Presently, diagnostic and follow-up methods for BC are expensive and invasive. Thus, the identification of novel predictive biomarkers for diagnosis, progression, and prognosis of BC is of paramount importance. To date, several studies have evidenced that cell-free DNA (cfDNA) found in liquid biopsies such as blood and urine may play a role in the particular scenario of urologic tumors, and its analysis may improve BC diagnosis report about cancer progression or even evaluate the effectiveness of a specific treatment or anticipate whether a treatment would be useful for a specific patient depending on the tumor characteristics. In the present review, we have summarized the up-to-date studies evaluating the value of cfDNA as potential diagnostic, prognostic, or monitoring biomarker for BC in several biofluids.

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Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring

Zeng

Wang

et al. 2023

Clinical and Translational Dis

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Urine‐based liquid biopsy has emerged as a non‐invasive and effective tool for early screening and diagnosis of bladder cancer. This review provides a comprehensive overview of the current urine‐based biomarkers and methods for the detection and monitoring of bladder cancer. We focus on biomarkers including tumour DNAs, proteins, microbiome, tumour RNAs, long non‐coding RNAs, transfer RNA‐derived fragments, messenger RNAs, microRNAs, circular RNAs, exosomes and extrachromosomal circular DNA.

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Urinary Cell-Free DNA IQGAP3/BMP4 Ratio as a Prognostic Marker for Non–Muscle-Invasive Bladder Cancer

Cited by 14 publications

References 28 publications

Urinary Cell-Free DNA in Bladder Cancer Detection

Urinary Cell-Free DNA in Bladder Cancer Detection

Circulating Cell-Free DNA in Liquid Biopsies as Potential Biomarker for Bladder Cancer: A Systematic Review

Recent development of urinary biomarkers for bladder cancer diagnosis and monitoring

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