Urinary Bladder Leiomyosarcoma: Primary Surgical Treatment

Abstract

Cases of bladder leiomyosarcoma represent 0.1% of all nonurothelial tumors. We present a case report of a 73-year-old man who underwent a radical cystoprostatectomy for a high-grade bladder leiomyosarcoma with an ileal diversion. The patient recovered uneventfully and no surgical margins were verified in final pathology. Early follow-up at 3 months shows no signs of computed tomography recurrence and adequate adaptation to ileal diversion. Although bladder sarcomas were once thought to have a grim prognosis, recent studies suggest that adequate surgical treatment is able to achieve optimal cancer control outcomes.

Organ preservation in leiomyosarcoma bladder: Case report and review of literature

“…These include mesenchymal tumors, among which LMS are the most common, accounting for 0.1% of all primary bladder tumors. [ 1 ]…”

“…The proposed risk factors for the development of LMS within the bladder include the presence of retinoblastoma gene mutation, cyclophosphamide exposure, and pelvic radiation therapy, however, the vast majority of cases, as in our patient, do not have any identifiable predisposing causes. Although the peak incidence has been reported to be in the seventh to ninth decade of life,[ 1 2 3 ] patients with the afore-mentioned risk factors present at a younger age, in the second to third decades. [ 4 ]…”

“…reported poorly differentiated histology in 63.2% cases in a series of 183 LMS, with 50% cases presenting with locally advanced or metastatic disease. [ 1 ]…”

“…Partial cystectomy has historically been deemed as palliative surgery with poorer results in comparison to radical surgery. [ 1 2 ] We report a case of LMS bladder managed with partial cystectomy and no adjuvant therapy who remains disease free on follow-up of 48 months.…”

Total endoscopic management of a patient with urinary bladder leiomyosarcoma presenting with dysuria: A case report

“…Herein, we present the case of total endoscopic management of a patient with urinary bladder leiomyosarcoma presenting with dysuria. 1 , 2 , 3 , 4 …”