Organ preservation in leiomyosarcoma bladder: Case report and review of literature

Abstract

Leiomyosarcomas (LMSs) account for <0.1% of all bladder malignancies. Due to the infrequent occurrence of these tumors, established guidelines for management are lacking. Conventionally, radical extirpative surgery has been advocated. We present our experience with organ preservation in a young male presenting with LMS bladder. A brief review of literature supporting organ preservation in selected cases has also been presented.

Leiomyosarcoma of the bladder: A review and a report of four further cases

“…From a pathological point of view, the different publications suggest the use of three main histological and prognostic classifications: the NCI, FNCLCC and Mayo LMS-UB grading system which take into consideration the degree of differentiation, mitosis number (per 10 CFG), necrosis and nuclear atypia [ 10 , 11 ].…”

“…In our study, adjuvant chemotherapy was indicated in one case but refused by the patient. Radical cystectomy surgery is most commonly recommended, while partial cystectomy is used for small tumours and patients refusing radical treatment [ 3 , 11 ].…”

“…Ryuta S et al described a case of bladder leiomyosarcoma treated by TURB followed by re-resection after 70 days. Follow-up was 18 months with no tumour recurrence [ 11 ]. In our study, this approach was used for a patient with a two-year recovery.…”

A brief review and case report of urothelial carcinoma and metachronous leiomyosarcoma of the bladder at the same anatomic region

“…One of them is the relationship between long-term chemotherapy of cyclophosphamide and bladder sarcoma, and a minority reports have revealed this point. Apart of above mentioned, the presence of urinary bladder diverticulum, abuse use of ketamine, 3 and radiation exposure, 4 could be a contribution of risk factor to this rarity. We could not discern any those factors, while our patient had a history of smoking and type II diabetes mellitus.…”

Bladder leiomyosarcoma originating from the muscular elements of the bladder mucosa (clinical case)

“…Обсуждение Неуротелиальные опухоли составляют менее 5 % всех злокачественных новообразований мочевого пу зыря [1]. При этом ЛМС является крайне редкой опу холью мочевого пузыря, встречающейся менее чем в 0,1 % случаев и развивающейся в собственно мышеч ном слое мочевого пузыря [2]. Первый случай обнару жения ЛМС мочевого пузыря был представлен в 1946 г. W. Baurys и R.R.…”