Urinary bladder hyperplasia in the rat: Non-specific pathogenetic considerations using a beta-lactam antibiotic

Iatropoulos, Michael J.; Newman, Arthur J.; Dayan, Anthony D.; Scampini, Giovanna; Mazué, G

doi:10.1016/s0940-2993(11)80098-9

Cited by 11 publications

(4 citation statements)

References 27 publications

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“…This UB finding occurs in extreme pH (acidic or alkaline) changes (Iatropoulos et al, 1994). The increased proliferation with NTA demonstrates that the rats were responsive to a proliferative stimulus, but 28 days was not sufficient time to develop a simple or diffuse hyperplasia.…”

Section: Discussionmentioning

confidence: 88%

The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats

Iatropoulos

Duan

Schmuck

et al. 2015

Experimental and Toxicologic Pathology

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Section: Discussionmentioning

confidence: 88%

The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats

Iatropoulos

Duan

Schmuck

et al. 2015

Experimental and Toxicologic Pathology

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“…The aim of the hyperplasia analysis is to assess whether MSC treatment protects the functional integrity of the urothelium as well as preventing regeneration abnormalities. The length of the urothelium with hyperplasia was measured and related to the total size of the urothelium which represents a percentage of the length of the urothelium with hyperplasia, as previously defined [ 32 ]. Figure 4 A shows representative pictures of the hyperplasia (H) visible on the HES sections.…”

Section: Resultsmentioning

confidence: 99%

Mesenchymal stem cells limit vascular and epithelial damage and restore the impermeability of the urothelium in chronic radiation cystitis

et al. 2023

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Background Cellular therapy seems to be an innovative therapeutic alternative for which mesenchymal stem cells (MSCs) have been shown to be effective for interstitial and hemorrhagic cystitis. However, the action of MSCs on chronic radiation cystitis (CRC) remains to be demonstrated. The aim of this study was to set up a rat model of CRC and to evaluate the efficacy of MSCs and their mode of action. Methods CRC was induced by single-dose localized irradiation of the whole bladder using two beams guided by tomography in female Sprague–Dawley rat. A dose range of 20–80 Gy with follow-up 3–12 months after irradiation was used to characterize the dose effect and the kinetics of radiation cystitis in rats. For the treatment, the dose of 40 Gy was retained, and in order to potentiate the effect of the MSCs, MSCs were isolated from adipose tissue. After expansion, they were injected intravenously during the pre-chronic phase. Three injections of 5 million MSCs were administered every fortnight. Follow-up was performed for 12 months after irradiation. Results We observed that the intensity and frequency of hematuria are proportional to the irradiation dose, with a threshold at 40 Gy and the appearance of bleeding from 100 days post-irradiation. The MSCs reduced vascular damage as well as damage to the bladder epithelium. Conclusions These results are in favor of MSCs acting to limit progression of the chronic phase of radiation cystitis. MSC treatment may afford real hope for all patients suffering from chronic radiation cystitis resistant to conventional treatments.

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“…A synthetic β-lactam caused urothelial hyperplasia in rats but scientist suggested that chemical is not toxic to human [87]. In a case study, it has been reported that penicillin-G induced haemorrhagic cystitis, but the patient recovered in 8 days [88].…”

Section: Toxicity Of β-Lactam Antibioticsmentioning

confidence: 99%

Toxicity of β-Lactam Antibiotics: Pathophysiology, Molecular Biology and Possible Recovery Strategies

Bozcal¹,

Dagdeviren²

2017

Poisoning - From Specific Toxic Agents to Novel Rapid and Simplified Techniques for Analysis

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Beta (β)-lactam antibiotics are wide-spectrum antibiotics used for various bacterial infections. The aim of this chapter is to summarize the knowledge about the toxicity of β-lactam antibiotics and issues associated to their inappropriate use. This review has highlighted that β-lactam antibiotics are a group of products that have a chemical structure characterized by a β-lactam ring and are one of the most common antibacterial agents. However, due to the inappropriate use including abuse and misuse, resistance to the β-lactam antibiotics is currently a global crisis. Moreover, even when used appropriately, they have been linked to triggering allergic reactions like urticaria, bronchoconstriction, also severe conditions like immune-mediated haemolytic anaemia and intravascular haemolysis. It is known that some β-lactam antibiotics are neurotoxic, some are nephrotoxic, some are genotoxic and some are toxic to urogenital system. Several factors are involved in the occurrence of toxic efects including the dosage and renal status. Several strategies are possible to overcome β-lactam antibiotics-triggered toxicity, including rational prescribing, substitution combination and phage therapy which seems promising. Public health education for clinical teams and patients is essential in ensuring that this group of antibiotics are retained in therapeutics.

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Urinary bladder hyperplasia in the rat: Non-specific pathogenetic considerations using a beta-lactam antibiotic

Cited by 11 publications

References 27 publications

The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats

The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats

Mesenchymal stem cells limit vascular and epithelial damage and restore the impermeability of the urothelium in chronic radiation cystitis

Toxicity of β-Lactam Antibiotics: Pathophysiology, Molecular Biology and Possible Recovery Strategies

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