The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats

Iatropoulos, Michael J.; Duan, Jian-Dong; Schmuck, Gabriele; Williams, Gary M.

doi:10.1016/j.etp.2015.06.002

Cited by 4 publications

(2 citation statements)

References 17 publications

(31 reference statements)

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“…Propoxur exposure increased MMP-2 expression and invasion of cancer cells through the activation of the mitogen activated protein kinase (MAPK) member extracellular related kinase (ERK)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling in breast cancer [89]. It is a carbamate insecticide which induced urinary bladder cancer in Wistar rats when fed at 5000 ppm in the Altromin 1321 diet [207]. MMP-2 is one of the major collagenases in the MMP family which has been significantly correlated with BlCa progression through tumor invasion [208].…”

Section: Pesticide Effects On Other Therapies For Bladder Cancermentioning

confidence: 99%

Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies

Lucchesi,

Vasilatis,

Mantrala

et al. 2023

IJMS

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Multiple risk factors have been associated with bladder cancer. This review focuses on pesticide exposure, as it is not currently known whether agricultural products have a direct or indirect effect on bladder cancer, despite recent reports demonstrating a strong correlation. While it is known that pesticide exposure is associated with an increased risk of bladder cancer in humans and dogs, the mechanism(s) by which specific pesticides cause bladder cancer initiation or progression is unknown. In this narrative review, we discuss what is currently known about pesticide exposure and the link to bladder cancer. This review highlights multiple pathways modulated by pesticide exposure with direct links to bladder cancer oncogenesis/metastasis (MMP-2, TGF-β, STAT3) and chemoresistance (drug efflux, DNA repair, and apoptosis resistance) and potential therapeutic tactics to counter these pesticide-induced affects.

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Section: Pesticide Effects On Other Therapies For Bladder Cancermentioning

confidence: 99%

Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies

Lucchesi,

Vasilatis,

Mantrala

et al. 2023

IJMS

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“…Although, these are considered less harmful because their bioaccumulation is apparently less, their potential danger arises from continuing exposure that provokes diverse long-term effects, comprising muscle contractions, convulsions, respiratory depression and hypotension, even fatal cardiac arrhythmias, severe cerebral disfunction and death through asphyxia. [1][2][3][4][5][6] Propoxur (2-isopropoxyphenyl-N-methylcarbamate), also known as Baygon®, see Scheme 1, is still one of the most widely and effectively used carbamate pesticides 7 to control flies and mosquitoes. [8][9][10] However, studies carried out in rats proved that propoxur bears a potentially carcinogenic character, 11,12 apart that exposure during pregnancy to this type of pesticides, has been associated to leukemia.…”

mentioning

confidence: 99%

Construction and Optimization of a Novel Acetylcholine Ion-Selective Electrode and its Application for Trace Level Determination of Propoxur Pesticide

Juárez-Gómez

Ramı́rez-Silva

Guzmán-Hernández

et al. 2020

J. Electrochem. Soc.

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This research presents the construction and optimization of an acetylcholine, ACh, ion-selective electrode, ACh-ISE, aiming to use it for the quantification of the propoxur pesticide. This analytical quantification is based on the evaluation of the acetylcholinesterase enzyme inhibition percentage, %EI, provoked by the pesticide, as a function of propoxur concentration; where the %EI is followed by means of the potentiometric determination of acetylcholine that does not react with the enzyme, using the constructed ACh-ISE. It was found that the ACh-ISE depicted a sub-Nernstian slope of (42.7 ± 2.8) mV decade −1 , a ACh detection limit of 1.2 × 10 −5 mol l −1 , and the selectivity constants, K pot , of 0.03 and 0.24 for Na + and Choline + cations, respectively. K + and Ca 2+ did not interfere. This new method designed to determine propoxur attained an outstanding detection limit of (2.89 ± 0.97) × 10 −17 mol l −1 and a linear interval of (5.5 × 10 −15 -1.0 × 10 −4 ) mol l −1 .

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Electrochemical quantification of propoxur using a boron-doped diamond electrode

Selva

Paixão

2016

Diamond and Related Materials

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The urinary bladder carcinogen propoxur does not produce genotoxic effects in the urinary bladder of Wistar male rats

Cited by 4 publications

References 17 publications

Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies

Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies

Construction and Optimization of a Novel Acetylcholine Ion-Selective Electrode and its Application for Trace Level Determination of Propoxur Pesticide

Electrochemical quantification of propoxur using a boron-doped diamond electrode

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