Urinary Bladder Cancer Risk Factors: A Lebanese Case-Control Study

Kobeissi, Loulou; Yassine, Ibrahim; Jabbour, Michel E.; Moussa, Mohamad; Dhaini, Hassan R.

doi:10.7314/apjcp.2013.14.5.3205

Cited by 34 publications

(33 citation statements)

References 36 publications

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“…However, this null association could be due a lack of consideration for the potential role of the environment; in other words, the gene-environment interaction role in cancer risk, as mentioned by Liu RY et al (Liu et al, 2012). Epidemiologic studies have revealed significant associations between bladder cancer and environmental factors such as tobacco smoking and occupational exposures (Letasiova et al, 2012;Kobeissi et al, 2013). It has been shown that smoking increases the production of numerous pro-inflammatory cytokines such as TNF-α, IL-1, IL-6, IL-8 GM-CSF and decreases the levels of anti-inflammatory cytokines such as IL-10 (Hagiwara et al, 2001;Sopori, 2002;Arnson et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Ebadi

Jahed²,

Mivehchi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Interleukin-12 (IL-12) as an antitumor and interleukin-6 (IL-6) as an inflammatory cytokine, are immunomodulatory products that play important roles in responses in cancers and inflammation. We tested the association between two polymorphisms of IL-12(1188A>C; rs3212227) and IL-6 (-174 C>G) and the risk of bladder cancer in 261 patients and 251 healthy individuals. We also investigated the possible association of these SNPs in patients with high-risk jobs and smoking habits with the incidence of bladder cancer. The genotype distributions of IL-6 (-174 C/G) genotype were similar between the cases and the control groups; however, among patients with smoking habits, the association between IL-6 gene polymorphism and incidence of bladder cancer was significant. After a control adjustment for age and sex, the following results were recorded: CC genotype (OR= 2.11, 95%CI=1.56-2.87, p=0.

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Section: Discussionmentioning

confidence: 99%

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Ebadi

Jahed²,

Mivehchi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Bladder cancer is known to be caused by the chronic inflammation associated with the presence of bladder stones (5), which results in neoplastic differentiation (6).…”

Section: Introductionmentioning

confidence: 99%

Incidence of renal carcinoma in non-functioning kidney due to renal pelvic stone disease

Zengın

Tanık

Şener

et al. 2015

Molecular and Clinical Oncology

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Abstract. The objective of this study was to report our pathological findings in nephrectomy specimens from patients treated for non-functioning hydronephrotic kidney due to renal pelvic stone disease. A total of 97 patients who underwent nephrectomy for non-functioning hydronephrotic kidneys between January, 2011 and June, 2014 were retrospectively reviewed. A non-functioning kidney was defined as one having paper-thin parenchyma on urinary ultrasound or computed tomography, exhibiting no contrast visualization in the collecting duct system on intravenous urography and having a split renal function of <10% on nuclear renal function studies. Following pathological evaluation, 9 patients were diagnosed with xanthogranulomatous pyelonephritis, 9 with malignant tumors and 79 with chronic pyelonephritis. Of the patients with chronic pyelonephritis, 2 also had renal adenomas. The malignant tumors included 3 transitional cell carcinomas (TCC), 2 squamous cell carcinomas (SCC), 3 renal cell carcinomas (RCC) (1 sarcomatoid, 1 papillary and 1 clear cell RCC), whereas 1 patient had concurrent RCC and TCC. In conclusion, non-functioning kidneys, particularly those with kidney stones, should be managed as possible malignancies, due to the higher incidence of malignant tumors in such patients compared with the normal population.

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“…And this figure increases annually 1 . In Europe it is the fifth common cancer in male -14.4 cases per 100 000 population (mortality rate -4.5).…”

Section: Introductionmentioning

confidence: 96%

Multifocal primary tumour with lesions in prostate gland and urinary bladder: clinical case

Романюк

Lyndin

Sikora

et al. 2017

Bangladesh J Med Sci

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In some cases a combination of several malignant tumours in one person can be observed. In such case it is the multifocal primary tumour (MPT). The tumours combination in genitourinary system is rare phenomenon, including a rare combination of prostate and urinary bladder cancers. These pathologies can be caused by both the endogenous factors -age, gender, heredity, inflammatory and proliferative processes, abnormal inclusions (calculi and amyloids) and exogenous factors, among which the leading cause is the environmental pollution (heavy metals salts and others), bad habits, occupational hazards, oncogenic viruses and ionizing radiation. A 76 -year-old male patient, Ukrainian, was hospitalized at urology department with complaints on pollakiuria, frequent urinary retention, haematuria appeared about 1 month before. After examination of patient the preliminary diagnosis was made: «Urinary bladder cancer, acute urinary retention, macrohematuria and posthemorrhagic anemia». Based on the histological and immunohistochemical examinations, the final diagnosis was determined: combined malignant tumours -acinar adenocarcinoma of prostate index 9 (5 + 4) accordimg to D.F. Gleason and invasive urothelial carcinoma of the urinary bladder. This clinical case demonstrates that the probability of combined oncologic cancer pathology with lesions in one system is rather high. Therefore, in order to exclude the cancer combinations, the patients with malignant tumour in the genitourinary system should undergo a complex examination.

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Urinary Bladder Cancer Risk Factors: A Lebanese Case-Control Study

Cited by 34 publications

References 36 publications

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Interleukin-12 and Interleukin-6 Gene Polymorphisms and Risk of Bladder Cancer in the Iranian Population

Incidence of renal carcinoma in non-functioning kidney due to renal pelvic stone disease

Multifocal primary tumour with lesions in prostate gland and urinary bladder: clinical case

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