Urinary Bladder Cancer: A Clinicopathological and Histological Study

Sathya, M; Chinnaswam, P.

doi:10.3923/jms.2014.206.209

Cited by 7 publications

(10 citation statements)

References 6 publications

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“…In this study, non-muscle invasive tumors have been noted in approximately 74% of the cases (stage Ta + T1). Similar findings have also been reported in other studies [13,[16][17][18].…”

Section: Discussionsupporting

confidence: 92%

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The Diagnostic Role of p53 and Ki 67 Immunohistochemistry in Evaluation of Urinary Bladder Carcinomas in Egyptian Patients

Mohamed¹

2019

IJCM

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Background: Urothelial carcinomas (UC) are the most common cancers of urinary bladder responsible for a significant proportion of cancer morbidity and mortality. In Egypt, bladder cancer is the second most common malignancy. We did the present investigation to exhibit the clinicohistopathological highlights and to associate the p53 and Ki 67 immunoexpression with grade and stage of bladder carcinomas. Materials and Methods: sixty-two cases of bladder neoplasm were investigated. Grading and staging was done. An immunohistochemical assay for p53 and Ki 67 was performed in altogether cases, with relation to clinicopathological parameter. Results: There was a significant association of p53 and Ki 67 overexpression in high grade with the epithelial type (P=0.0001) & (P=.0.01) respectively. While there was a statistically significant association of high expression of P53 in PT1 compared to PTa and PT2 (p=0.000001). There was a significant correlation between Ki 67 in staging pT1 (pTa + pT1/pT2, P = 0.000001; pTa/ pT1, P = 0.000001; pT1/pT2, P = 0.000002). Conclusion: The role of p53 and Ki 67 immunohistochemical relativities in the differential diagnosis and prognosis of urinary bladder carcinomas in step with the pathological stage and histologic grade of the neoplasm, will be understood due to unique biology and pathogenic features of these tumors. Thus, this study supports the opinion that combined use of p53 and Ki 67 immunostaining markers may help as further prognostic clue alongside with histologic grading and staging in bladder carcinomas.

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“…In this study, non-muscle invasive tumors have been noted in approximately 74% of the cases (stage Ta + T1). Similar findings have also been reported in other studies [13,[16][17][18].…”

Section: Discussionsupporting

confidence: 92%

“…As well as, the predominant histological variant in the present study was urothelial carcinoma. Several authors have also jointly printed similar data [5,10,13,[16][17]20]. Adenocarcinomas and squamous cell carcinomas are rare tumors of the bladder representing approximately 1.6% of all carcinomas of the bladder that almost match our study.…”

Section: Discussionsupporting

confidence: 74%

The Diagnostic Role of p53 and Ki 67 Immunohistochemistry in Evaluation of Urinary Bladder Carcinomas in Egyptian Patients

Mohamed¹

2019

IJCM

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“…Present study showed increased prevalence of high grade urothelial carcinoma accounting for 74.1% and our results are in concordance with Vibhav KG et al, [16] Vaidya S et al, [12] Mahesh K et al study [17] and Satya et al [19] as shown in table 6.…”

Section: Graph 2 Clinical Presentations Of the Patients With Bladder Neoplasms Discussionsupporting

confidence: 92%

Cystoscopic Biopsies of Bladder Neoplasms

N²,

Dravid

et al. 2019

APALM

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Introduction: Urinary bladder neoplasms constitute an important source of clinical signs and symptoms which are more disabling than lethal. The present study aimed to study the prevalence of bladder neoplasms and to study the clinico-histomorphological features of various bladder neoplasms along with special emphasis on grading and staging of the bladder tumours. Materials and Methods:The present study is a five years retrospective study. All patients who visited to urologyoutpatient department with lower urinary tract symptoms and obstructive bladder symptoms were subjected to cystoscopy. The detailed clinico-histomorphological features of cystoscopicbiopsies are studied using WHO/ISUP 2004 histological grading and TNM stagingwere used in classifying the bladder tumours.Results: Out of 239 cystoscopic biopsies, the neoplastic lesions constituted 76.6%of the cases Among the neoplastic, benign lesions accounted for 12.9% of the cases (31 cases) and malignant lesions accounted for83 % of the cases (152 cases). Among the malignant lesions,urothelial carcinoma was the commonest accounting for 75.9% of the cases with increased prevalence of high grade papillary urothelial carcinoma (74.1%) and invasive papillary urothelial carcinoma accounting for 73.75% of the cases. Conclusions:The present study has stressed the importance of histopathological examination with special emphasis on the study of serial sections and the importance of inclusion ofdetrusormuscle in the biopsy for accurate grading and staging so as to decrease the morbidity andmortality and initiate the early management of bladder tumours.

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“…Present study showed increased prevalence of high grade urothelial carcinoma accounting for 55.43% and is in concordance with Vibhav KG et al [16] and Vaidya S et al, [12], Mahesh K et al [17] and Satya et al [18] as shown in table 6.…”

Section: Citationsupporting

confidence: 80%

Untitled

2016

ICPJL

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Introduction: Urinary bladder lesions constitute an important source of clinical signs and symptoms which are more disabling than lethal. The present study aimed to study the frequency of bladder lesions and to study the clinicohistomorphological features of various bladder lesions with special emphasis on grading and staging of the bladder tumours. Materials and methods:The present study is a 3 years prospective study carried out in the department of pathology. All patients who visited to urology outpatient department with lower urinary tract symptoms and obstructive bladder symptoms were subjected to cystoscopy. The detailed clinico-histomorphological features of cystoscopy biopsies are studied using WHO/ISUP 2004 histological grading and TNM staging are used in classifying the bladder tumours.Results: Out of 139 cystoscopy biopsies, the non-neoplastic bladder lesions constituted 26.6 % and neoplastic lesions constituted 73.38%. Among the neoplastic, benign lesions showed 10.79% of the cases and malignant lesions showed 62.58% of the cases. Among the malignant lesions, urothelial carcinoma was the commonest accounting for 55.39% of the cases with increased prevalence of high grade papillary urothelial carcinoma (55.43%) and invasive papillary urothelial carcinoma accounting for 78.25% of the cases. Conclusions:The present study has stressed the importance of Histopathological examination with special emphasis on the study of serial sections, inclusion of smooth muscle in the biopsy for accurate grading and staging so as to decrease the mortality and morbidity due to bladder tumours. All the patients who visited the urology outpatient department (OPD) with lower urinary tract symptoms and obstructive urinary symptoms were included in the study. After the informed written consent of the patients, fiberoptic cystoscopy bladder biopsies were taken from the walls of the bladder. The cystoscopic bladder biopsies taken were fixed in 10% buffered formalin and then processed with embedding in paraffin wax. Four microns thick sections were taken and stained with regular haematoxylin and eosin stain (H and E). The study of biopsy specimens along with the histomorphological changes under low and high power magnification were studied by light microscope. The WHO/ISUP -2004 grading system was used to grade the bladder neoplasms 7 and staging was done according to TNM staging [7]. Keywords:Inclusion criteria: All the transurethral resection of bladder tissue (TURBT) biopsies received in the department of pathology.Exclusion criteria: Autolysed and inadequate biopsies were excluded. ResultsOut of total 139 cases, 71cases (51.1%) were males and 68 cases (48.9%) were females with peak age incidence is between 60-69 years as shown in graph 1. In the study, we found that the majority of the patients with benign lesions presented with lower urinary tract symptoms (LUTS) accounting for 82.7% of the cases and those with malignant lesions present with haematuria accounting for 90.8% of the cases as shown in graph 2. The detai...

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Urinary Bladder Cancer: A Clinicopathological and Histological Study

Cited by 7 publications

References 6 publications

The Diagnostic Role of p53 and Ki 67 Immunohistochemistry in Evaluation of Urinary Bladder Carcinomas in Egyptian Patients

The Diagnostic Role of p53 and Ki 67 Immunohistochemistry in Evaluation of Urinary Bladder Carcinomas in Egyptian Patients

Cystoscopic Biopsies of Bladder Neoplasms

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