The Diagnostic Role of p53 and Ki 67 Immunohistochemistry in Evaluation of Urinary Bladder Carcinomas in Egyptian Patients

Mohamed, Sahar Ali

doi:10.11648/j.ijcm.20190301.11

Cited by 4 publications

(4 citation statements)

References 13 publications

(36 reference statements)

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“…In pT1 stage, Ki-67 expression was variable from low to high intensity, as well as in the pT2 stage. Similar results were found in Ali Mohammed et al study, but it should be mentioned that the study included twice as much patients [26]. As Ki-67 is a cell cycle and proliferation regulative protein, it is probably capable of predicting tumor behavior based on histological grading and staging.…”

Section: Discussionsupporting

confidence: 83%

Predictive value of GATA3 and Ki-67 expression in biopsy and transurethral resection specimens in patients with urothelial carcinoma of the urinary bladder

2022

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Introduction/Objective. Urothelial carcinoma is the most commonly diagnosed malignancy of urinary bladder in clinical and pathohistological practice where various prognostic factors play significant role. One of the most important pathohistological prognostic factors is the intensity of immunohistochemical staining. Among various immunohistochemical markers that have been proven to influence disease progression and patient?s survival, role of Ki-67 and GATA3 in prediction of disease prognosis has not been completely clarified yet. The aim of this study was to determine the predictive value of GATA3 and Ki-67 mutual expression in urothelial carcinoma. Methods. 80 patients were included in this study, where 4 groups were formed based on the pathological stage of urothelial carcinoma. After using preferred antibodies, their staining intensity was analyzed semiquantitatively. Results. Results showed that there was statistically important significance between type of urothelial carcinoma, pathological stage and invasiveness and different grades of GATA3 expression, as well as statistically important significance between type of urothelial carcinoma and pathological stage and different grades of Ki-67 expression. The regression model showed low value of GATA3 and Ki-67 mutual expression. There was also a statistical significance considering pathological stage and invasiveness of the tumor in survival analysis. Conclusion. Predictive value of GATA3 and Ki-67 mutual expression resulted as low from this study, but to our knowledge it was the first one to examine their predictive capability on biopsy and transurethral resection specimens.

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Section: Discussionsupporting

confidence: 83%

Predictive value of GATA3 and Ki-67 expression in biopsy and transurethral resection specimens in patients with urothelial carcinoma of the urinary bladder

2022

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“…It was observed that 31 (54.4%) patients had high grade carcinoma and 26 (45.6%) patients had low grade carcinoma. Mohamed in his study found 79% high grade and 21% low grade tumor 20 . Chinnasamy et al observed 63.5% high grade and 36.5% low grade carcinoma 18 .…”

Section: Resultsmentioning

confidence: 89%

“…Chou et al (2013) also found 59.5% MIBC and 40.5% NMIBC 21 . On the other hand, Mohamed found 72.6% NMIBC and 25.8% MIBC 20 . Xu et al found 69.4% NMIBC and 30.6% MIBC 1 .…”

Section: Resultsmentioning

confidence: 94%

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Immunoexpression of p53 and Ki-67 in Urinary Bladder Carcinoma and Their Association with Tumor Grade and Muscle-invasiveness

Chowdhury AS,

Hye AQMA,

Mimi SA

et al. 2024

JSWMC

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Background: Urinary bladder carcinoma is one of the threatening causes of human morbidity and mortality. Various molecular studies and prognostic biomarkers are helpful to assess the outcome of urinary bladder carcinoma. High expression of p53 and Ki-67 represents the aggressiveness of the disease and indicates poor prognosis. Methods: This cross-sectional study was conducted at the Department of Pathology, Sylhet MAG Osmani Medical College from September 2018 to July 2020 to observe the immunoexpression of p53 and Ki-67 in urinary bladder carcinoma and their association with tumor grade and muscle-invasiveness. Total 57 transurethral resection (TURBT) samples of radiologically and clinically suspected bladder tumor cases were diagnosed histopathologically included in the study. Results: Age of the study patients ranged from 35 to 80 years with a mean of 60.60 ± 11.14 and male to female ratio was 4.7:1. There were 31 (54.4%) high grade and 26 (45.6%) low grade urinary bladder carcinomas on histopathological examination. Thirty (52.6%) cases were histopathologically muscle invasive bladder carcinoma (MIBC) and 27 (47.4%) cases were non-muscle invasive bladder carcinoma (NMIBC). Positive p53 expression was observed in 24 (77.4%) cases of high grade carcinoma while only in 6 (23.1%) cases of low grade urinary bladder carcinoma. Positive p53 expression was seen in 22 (73.3%) cases of MIBC and 8 (29.6%) cases of NMIBC. Ki-67 expression was found positive in 27 (87.1%) cases of high grade carcinoma while only in 7 (26.9%) cases of low grade urinary bladder carcinoma. Positive Ki-67 expression was seen in 25 (83.3%) cases of MIBC and 9 (33.3%) cases of NMIBC. Statistically significant association (P<0.05) was observed in histopathological grades and muscle invasiveness of UBC with p53 and Ki-67 expression. Conclusion: p53 and Ki-67 immunomarker may be helpful to provide additional prognostic information in urinary bladder carcinoma.

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Moringa Oliefera: A Phytochemical and Biological Study in Combination with Medicinal Potential Spices

Devi,

Sudhakar,

Surekha

et al. 2024

Proc. Natl. Acad. Sci., India, Sect. A Phys. Sci.

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The Diagnostic Role of p53 and Ki 67 Immunohistochemistry in Evaluation of Urinary Bladder Carcinomas in Egyptian Patients

Cited by 4 publications

References 13 publications

Predictive value of GATA3 and Ki-67 expression in biopsy and transurethral resection specimens in patients with urothelial carcinoma of the urinary bladder

Predictive value of GATA3 and Ki-67 expression in biopsy and transurethral resection specimens in patients with urothelial carcinoma of the urinary bladder

Immunoexpression of p53 and Ki-67 in Urinary Bladder Carcinoma and Their Association with Tumor Grade and Muscle-invasiveness

Moringa Oliefera: A Phytochemical and Biological Study in Combination with Medicinal Potential Spices

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