Urinary bladder adenocarcinoma arising in a spina bifida patient

Bitar, Mireille; Mandel, Edmund; Kirschenbaum, Alexander; Unger, Pamela

doi:10.1016/j.anndiagpath.2006.06.002

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Less than 20 cases of patients with spina bifida (SB) and urothelial bladder cancer have been reported in the literature, mainly presenting with locally advanced or metastatic disease [3]. Patients present with nonspecific symptoms, since gross hematuria was the main symptom in only 63% of cases.…”

Section: Discussionmentioning

confidence: 99%

Urothelial carcinoma of the sarcomatoid variant in a young patient with spina bifida: a case report and review of the literature

et al. 2009

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IntroductionPatients with neurogenic bladder due to spina bifida are considered to be at increased risk for aggressive bladder cancer. We present a unique case of a 32-year-old woman with spina bifida diagnosed with sarcomatoid urothelial carcinoma of the bladder and report diagnosis and management.Case presentationA 32 year old woman with neurogenic bladder managed with intermittent self catheterisations, presented with gross hematuria. On cystoscopy, she had a bulky bladder mass on the posterior bladder wall. Bladder biopsies revealed sarcomatoid variant of bladder transitional cell carcinoma. Treatment included radical cystectomy with ileal conduit diversion and adjuvant chemotherapy with excellent intermediate term follow up.ConclusionPatents with neurogenic bladder managed with intermittent self catheterisations need periodical follow up due to increased risk for aggressive bladder cancer. Immediate radical cystectomy with adjuvant chemotherapy is the suggested treatment approach.

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Section: Discussionmentioning

confidence: 99%

Urothelial carcinoma of the sarcomatoid variant in a young patient with spina bifida: a case report and review of the literature

et al. 2009

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“…It has been suggested that the link between spina bifida and bladder cancer lies with the neurogenic bladder, where associated factors, such as chronic urinary tract infections, urothelial inflammation, indwelling catheters and a history of calculi, lead to an increased risk of bladder oncogenesis. [2][3][4][5] Of note, these associated risk factors are also observed in patients having spinal cord injuries; a 10% increased incidence of bladder cancer is seen with such patients having an indwelling catheter for more than 10 years. 2,6 Patients with spina bifida and bladder cancer typically present at a younger age, have varied tumour histology, are advanced in stage and ultimately have poor survival.…”

Section: Introductionmentioning

confidence: 99%

Radiation treatment of bladder squamous cell carcinoma in a patient with spina bifida: A case report

D’Souza

Morton²,

Chung³

2012

CUAJ

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“… 11 – 15 The reported incidence varies between 0.11% and 0.39% in different studies. 11 , 15 Transitional cell carcinoma is still the predominant overall pathological pattern, 16 but the incidence of squamous cell carcinoma has increased dramatically, especially in patients with chronic catheterization. 11 , 13 – 15 Austin et al 6 reported 19 patients (8 of their own and 11 previous published cases) with spina bifida and bladder cancer and concluded that these patients presented with an advanced stage (frequently muscle invasive) at a young age and exhibited poor survival.…”

Section: Discussionmentioning

confidence: 99%

A Large Bladder Tumor Covered With a Thick “Shell” of Necrotic Material

Wang¹,

Zhou

Gong

et al. 2016

Medicine

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Bladder tumor arising in a spina bifida patient is rare and may be clinically latent.We report the case of a 61-year-old female patient with spina bifida, neurogenic bladder, and a history of recurrent urinary tract infections. A B-ultrasound and non-contrast computed tomography scan did not reveal any bladder mass, but an unexplained “well-filled” bladder was observed, which was confusing as the catheter was present and open. However, a subsequent cystoscopic evaluation revealed a large bladder mass measuring 9.5 × 9.0 × 6.5 cm3, which almost filled the entire bladder. The mass had coarse and flocculent surface and seemed to be free from each observed wall of the urinary bladder. It was diagnosed as an infectious necrotic mass based on its appearance.During transurethral resection of the mass, a bladder tumor was suspected as small blood vessels and bleeding appeared within the inner layer of the mass. Pathological examination revealed necrotic material, inflammatory cells, and urothelial carcinoma cells. Then, a radical cystectomy was performed, and the pathological results indicated stage pT3bN0M0 transitional cell carcinoma. In the gross specimen, the base of the tumor measured 3 × 3 cm2 on the top of the back wall of the bladder.Bladder tumors may have atypical presentations in patients with spina bifida. Regular screening is helpful for earlier detection and improving outcomes of bladder tumors in such patients.

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Urinary bladder adenocarcinoma arising in a spina bifida patient

Cited by 4 publications

References 12 publications

Urothelial carcinoma of the sarcomatoid variant in a young patient with spina bifida: a case report and review of the literature

Urothelial carcinoma of the sarcomatoid variant in a young patient with spina bifida: a case report and review of the literature

Radiation treatment of bladder squamous cell carcinoma in a patient with spina bifida: A case report

A Large Bladder Tumor Covered With a Thick “Shell” of Necrotic Material

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