Radiation treatment of bladder squamous cell carcinoma in a patient with spina bifida: A case report

Abstract

Bladder cancer is the sixth most common cancer in Canada. While most patients present with transitional cell carcinoma, few present with squamous cell carcinoma (SCC). Risk factors for SCC include a history of chronic urinary tract infection, urothelial inflammation and indwelling catheters. We present the management of a patient with locally advanced SCC of the bladder.

Primary squamous cell carcinoma of the bladder presenting with colovesical and vesicocutaneous fistulae in a 29‐year‐old

“…SB patients diagnosed with bladder cancer have a median age of 41 years at diagnosis with 71% of patients presenting with stage III or IV disease, similar to our patient . Of note, the only significant modifiable risk factor for bladder cancer in these patients is long‐term indwelling catheter, whereas bladder cancer with ISC alone has not demonstrated a significant causality. However, it is well established that chronic inflammation such as in the context of long‐term ISC or indwelling catheter increases angiogenesis, cytokine production and cellular proliferation predisposing to oncogenic transformation.…”