Urinary Bisphenol A Levels in Young Men: Association with Reproductive Hormones and Semen Quality

Lassen, Tina Harmer; Frederiksen, Hanne; Jensen, Tina Kold; Petersen, Jørgen Holm; Joensen, Ulla Nordström; Main, Katharina M.; Skakkebæk, Niels E.; Juul, Anders; Jørgensen, Niels; Andersson, Anna‐Maria

doi:10.1289/ehp.1307309

Cited by 188 publications

(150 citation statements)

References 49 publications

(79 reference statements)

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“…The highest levels of urinary BPA have been associated with elevated estrogen levels in men (Kim et al, 2014;Lassen et al, 2014), as well as with elevated concentrations of serum LH and testosterone (Galloway et al, 2010;Lassen et al, 2014). Urinary BPA levels in BPAexposed workers, compared to non-exposed workers have also been associated with significantly higher risks of male sexual dysfunction (Li et al, 2010), decreased semen quality (Li et al, 2011), and decreased androgen levels (Zhou et al, 2013).…”

Section: Inhibin Bmentioning

confidence: 99%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

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WHAT IS KNOWN ALREADY:The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. STUDY DESIGN, SIZE, DURATION:Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB), and bisphenol A diglycidyl ether (BADGE) at 10 -9 to 10 -5 M for 24 h or 48h.PARTICIPANTS/MATERIALS, SETTING, METHODS: Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase 3 immunohistochemistry), and the levels of testosterone, insulin-like fator 3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). MAIN RESULTS AND THE ROLE OF CHANCE: A significant dose-dependent inhibition wasfound between testosterone levels measured in the culture medium and concentrations of BPA The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. WIDER IMPLICATIONS OF THE FINDINGS:Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis.

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Section: Inhibin Bmentioning

confidence: 99%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

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“…In men exposed to BPA in the workplace and patients in reproduction centres, a higher level of BPA in urine was linked to a lower number, concentration, and motility of sperm (Knez et al 2014;Lassen et al 2014). Nevertheless, in a study conducted by Mendiola et al (2010) on fertile men, the concentration of BPA in urine did not correlate with changes in semen parameters, despite the fact that a significant correlation was observed between the level of BPA in urine and the volume of seminal plasma or markers of free testosterone (Mendiola et al 2010).…”

Section: Influences Of Bpa On Reproduction Of Malesmentioning

confidence: 99%

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

Žalmanová¹,

Hošková²,

Nevoral³

et al. 2016

Czech J. Anim. Sci.

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A range of substances that are released into the environment, foodstuffs and drinking water as a result of human activity were originally considered relatively harmless, and it was only later that their adverse effects were discovered. In general the use of such substances is currently restricted, and they are often replaced by other substances. This applies also in the case of a range of endocrine disruptors. These substances have the capacity to disturb the balance of physiological functions of the organism on the level of hormonal regulation, and their pleiotropic spectrum of effects is very difficult to predict. Endocrine disruptors include the currently intensively studied bisphenol A (BPA), a prevalent environmental pollutant and contaminant of both water and foodstuffs. BPA has a significantly negative impact on human health, particularly on the regulation mechanisms of reproduction, and influences fertility. The ever increasingly stringent restriction of the industrial production of BPA is leading to its replacement with analogues, primarily with bisphenol S (BPS), which is not subject to these restrictions and whose impacts on the regulation of reproduction have not yet been exhaustively studied. However, the limited number of studies at disposal indicates that BPS may be at least as harmful as BPA. There is therefore a potential danger that the replacement of BPA with BPS will become one of the cases of regrettable substitution, in which the newly used substances manifest similar or even worse negative effects than the substances which they have replaced. The objective of this review is to draw attention to ill-advised replacements of endocrine disruptors with substances whose effects are not yet tested, and which may represent the same risks for the environment, for the reproduction of males and females, and for human health as have been demonstrated in the case of the originally used substances.

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“…BPA and its metabolites are widely distributed in humans and animals (Calafat et al, 2005;Melzer et al, 2010), and were detected in more than 90% of urine samples from the U.S. population in the 2003-2004 and 2005-2006 National Health and Nutrition Examination Survey (Calafat et al, 2008;Lakind and Naiman, 2011). As a known endocrine disruptor, BPA has been shown to interfere with hormonal and homeostatic systems, and BPA levels in human urine have been correlated with various diseases and adverse health outcomes (Braun et al, 2011;Carwile and Michels, 2011;Ehrlich et al, 2012;Lang et al, 2008;Lassen et al, 2014). BPA exposure has also been associated with reproductive dysfunctions, including reduction of testicular weight and sperm count, alterations of hormone levels, and impairment of spermatogenesis (Jin et al, 2013;Pacchierotti et al, 2008;Sakaue et al, 2001;Tiwari and Vanage, 2013;Wang et al, 2016).…”

mentioning

confidence: 99%

High-Content Analysis Provides Mechanistic Insights into the Testicular Toxicity of Bisphenol A and Selected Analogues in Mouse Spermatogonial Cells

Liang

Yin

et al. 2016

Toxicol. Sci.

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Bisphenol A (BPA), an endocrine-disrupting compound, was found to be a testicular toxicant in animal models. Bisphenol S (BPS), bisphenol AF (BPAF), and tetrabromobisphenol A (TBBPA) were recently introduced to the market as alternatives to BPA. However, toxicological data of these compounds in the male reproductive system are still limited so far. This study developed and validated an automated multi-parametric high-content analysis (HCA) using the C18-4 spermatogonial cell line as a model. We applied these validated HCA, including nuclear morphology, DNA content, cell cycle progression, DNA synthesis, cytoskeleton integrity, and DNA damage responses, to characterize and compare the testicular toxicities of BPA and 3 selected commercial available BPA analogues, BPS, BPAF, and TBBPA. HCA revealed BPAF and TBBPA exhibited higher spermatogonial toxicities as compared with BPA and BPS, including dose-and time-dependent alterations in nuclear morphology, cell cycle, DNA damage responses, and perturbation of the cytoskeleton. Our results demonstrated that this specific culture model together with HCA can be utilized for quantitative screening and discriminating of chemical-specific testicular toxicity in spermatogonial cells. It also provides a fast and cost-effective approach for the identification of environmental chemicals that could have detrimental effects on reproduction.

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Urinary Bisphenol A Levels in Young Men: Association with Reproductive Hormones and Semen Quality

Cited by 188 publications

References 49 publications

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

High-Content Analysis Provides Mechanistic Insights into the Testicular Toxicity of Bisphenol A and Selected Analogues in Mouse Spermatogonial Cells

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