Urinary biopyrrins levels are elevated in relation to severity of heart failure

Hokamaki, Jun; Kawano, Hiroaki; Yoshimura, Michihiro; Soejima, Hirofumi; Miyamoto, Shinzo; Kajiwara, Ichiro; Kojima, Sunao; Sakamoto, Tomohiro; Sugiyama, Seigo; Hirai, Nobumitsu; Shimomura, Hideki; Nagayoshi, Yasuhiro; Tsujita, Kenichi; Shioji, Izuru; Sasaki, Shinya; Ogawa, Hisao

doi:10.1016/j.jacc.2004.01.028

Cited by 62 publications

(44 citation statements)

References 40 publications

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“…Moreover, as demonstrated previously by several reports, including ours, OS level parameters were shown to have a significant correlation with hemodynamic measurements, natriuretic serum peptides, and other prognostic parameters of HF [9,15,16,17,18]. …”

Section: Discussionsupporting

confidence: 85%

Increased Serum Levels of Oxidative Stress Are Associated with Hospital Readmissions due to Acute Heart Failure

Rogowski

Shnizer²,

Wolff

et al. 2011

Cardiology

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Objectives: Inflammation and serum oxidative stress (OS) are important components in heart failure (HF) deterioration. In this study we tested the hypothesis that an increase in patients’ sera OS levels is associated with acute HF (AHF) readmissions. Methods: Thirty consecutive patients (mean age 71 ± 10 years) admitted with AHF were included in the study. Serum OS in these patients was measured in-hospital and repeatedly after discharge over a period of 8 weeks of follow-up in which we reordered patients’ HF readmissions. Of the 30 patients, 13 (43%) were readmitted (RAD group) and 17 (57%) did not require readmission (NRAD group). Results: OS levels before discharge from the first hospital admission in the 2 groups were similar (p = 0.84 and p = 0.56, respectively). However, using repeated measures ANOVA, we found that the interaction between the time points and the 2 groups of patients (RAD and NRAD) was statistically significant (p = 0.037). It is important to note that OS serum levels were more predictive of HF readmissions than were repeated simultaneous serum measurements of NT-proBNP (p = 0.97). Conclusions: Increased OS levels in AHF patients, after they have been discharged from the hospital, are associated with higher HF readmission rates. In AHF, OS is a dynamic parameter associated with HF deterioration.

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Section: Discussionsupporting

confidence: 85%

Increased Serum Levels of Oxidative Stress Are Associated with Hospital Readmissions due to Acute Heart Failure

Rogowski

Shnizer²,

Wolff

et al. 2011

Cardiology

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“…Acute decompensated heart failure is associated with oxidative stress [67][68][69] and disrupted NO signaling, 70 affecting ventricular and vascular function related to hemodynamic status 71,72 ( Figure 4). There are multiple theoretical benefits of H-ISDN in acute decompensated heart failure.…”

Section: Role In Acute Decompensated Heart Failurementioning

confidence: 99%

Hydralazine and Isosorbide Dinitrate in Heart Failure

et al. 2011

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“…Several markers of ROS burden have been shown to be altered in heart failure including: urinary byopyrrins (derived from the oxidative metabolism of bilirubin); urinary isoprostanes, 8-epi prostaglandin-F-a and plasma malonyldialdehyde (markers of lipid peroxidation), and whole blood reduced (GSH) and oxidised glutathione (GSSH) ratio [165][166][167]. These novel markers can currently be measured using commercially available enzyme linked-immunosorbent or colorimetric assays.…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

Biomarkers in heart failure: a clinical review

2008

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The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are frequently a measure of the degree of pathophysiological derangement or counter-regulatory processes occurring in heart failure and include biomarkers of neurohormonal activation, myocyte necrosis and myocardial remodelling amongst others. As such they may serve as an indicator of the presence, severity and possibly therapeutic response of the heart failure syndrome and may complement conventional clinical measurements and acumen. This may in turn lead to tangible clinical benefits and the targeting of intensified and often costly therapies to those most at risk. This article reviews and summarises the most extensively investigated biomarkers currently available, with an emphasis on clinical applicability and discusses the future evaluation of candidate biomarkers in patients with heart failure.

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Urinary biopyrrins levels are elevated in relation to severity of heart failure

Abstract: These results indicate that urinary biopyrrins levels are increased in patients with HF and are elevated in proportion to its severity.

Cited by 62 publications

References 40 publications

Increased Serum Levels of Oxidative Stress Are Associated with Hospital Readmissions due to Acute Heart Failure

Increased Serum Levels of Oxidative Stress Are Associated with Hospital Readmissions due to Acute Heart Failure

Hydralazine and Isosorbide Dinitrate in Heart Failure

Biomarkers in heart failure: a clinical review

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