Increased Serum Levels of Oxidative Stress Are Associated with Hospital Readmissions due to Acute Heart Failure

Abstract

Objectives: Inflammation and serum oxidative stress (OS) are important components in heart failure (HF) deterioration. In this study we tested the hypothesis that an increase in patients’ sera OS levels is associated with acute HF (AHF) readmissions. Methods: Thirty consecutive patients (mean age 71 ± 10 years) admitted with AHF were included in the study. Serum OS in these patients was measured in-hospital and repeatedly after discharge over a period of 8 weeks of follow-up in which we reordered patients’ HF readmissions. Of the 30 patients, 13 (43%) were readmitted (RAD group) and 17 (57%) did not require readmission (NRAD group). Results: OS levels before discharge from the first hospital admission in the 2 groups were similar (p = 0.84 and p = 0.56, respectively). However, using repeated measures ANOVA, we found that the interaction between the time points and the 2 groups of patients (RAD and NRAD) was statistically significant (p = 0.037). It is important to note that OS serum levels were more predictive of HF readmissions than were repeated simultaneous serum measurements of NT-proBNP (p = 0.97). Conclusions: Increased OS levels in AHF patients, after they have been discharged from the hospital, are associated with higher HF readmission rates. In AHF, OS is a dynamic parameter associated with HF deterioration.

Oxidative stress and liver disease

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Endothelial nitric oxide synthase polymorphism and prognosis in systolic heart failure patients

“…NO regulates changes in peripheral vascular tone, coronary blood flow and myocardial contractility, all important contributors in Heart failure (HF) disease. Moreover, inflammation and oxidative stress are also integral components in the progression of HF [3,4]. Accordingly, changes in eNOS activity and NO bioavailability may play an important role in the formation of reactive oxygen species and development of endothelial dysfunction, compromising cardiac performance and affecting HF progression [5].…”

Oxidative stress and ischemia-modified albumin in chronic ischemic heart failure

“…The role of oxidative stress in the development of cardiovascular injuries has been reliably established. 2 Clinical and experimental studies have produced substantial evidence that oxidative stress, defined as an extreme production of reactive oxygen species relative to antioxidant defense, plays a role in HF. An increased concentration of reactive radicals, particularly superoxide, has been linked to peripheral endothelial dysfunction, peripheral hypoperfusion, and exaggerated sympathetic nerve activity in patients with HF.…”