Endothelial nitric oxide synthase polymorphism and prognosis in systolic heart failure patients

Azzam, Naiel; Zafrir, Barak; Fares, Fuad; Smith, Yoav; Salman, Nabeeh; Nevzorov, R.; Amir, Offer

doi:10.1016/j.niox.2015.04.004

Cited by 7 publications

(7 citation statements)

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“… 29 Similarly, the clinical relevance of NO has been demonstrated in other studies that have associated polymorphisms that affect the concentration of NO with a prognosis of mortality resulting from cardiac disease. 30 , 31 The relationship between EAT and NO observed in the present study appeared to be associated with a population that also displayed specific cardiovascular risk factors. This finding further supports the notion that EAT may be a biomarker of endothelial dysfunction and demonstrates that it may have potential clinical utility for stratifying patients with cardiovascular risk factors according to atherogenic risk.…”

Section: Discussionsupporting

confidence: 50%

Pro-atherogenic mediators and subclinical atherogenesis are related to epicardial adipose tissue thickness in patients with cardiovascular risk

et al. 2016

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ObjectiveTo evaluate the relationship between pro-atherogenic biomarkers and epicardial adipose tissue (EAT) thickness in patients with cardiovascular risk factors.MethodsPlasma nitric oxide (NO), soluble intercellular adhesion molecule-1 and malondialdehyde (MDA) levels, EAT thickness, flow-mediated dilation (FMD) and carotid intima media thickness (CIMT) were determined in patients aged >18 years who were referred for echocardiography for heart ischemia or non-ischemic diseases. Cardiovascular risk factors (Framingham score [FS] ≥ 20) were weighted.ResultsHypertension, dyslipidaemia and type 2 diabetes mellitus were prevalent (≥55% of 40 patients). Patients with FS ≥ 20 (n = 21) showed significantly higher EAT and CIMT values. Globally, MDA, CIMT, age, waist circumference, high-density lipoprotein cholesterol (HDL-C) and FS were associated with EAT thickness. EAT was significantly associated with NO in patients with FS ≥ 20. Significant differences in EAT thickness were found between patients stratified by NO value, FMD, age, smoking status, dyslipidaemia, type 2 diabetes mellitus and FS. An EAT-associated atherogenic risk (CIMT ≥ 1 mm) model was statistically significant when MDA and type 2 diabetes mellitus were included.ConclusionEAT thickness was associated with MDA, CIMT, age, waist circumference, HDL-C and FS globally, but with NO only in patients with FS≥20. EAT may be used to identify vascular damage stage, possibly influenced by MDA and type 2 diabetes mellitus.

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Section: Discussionsupporting

confidence: 50%

Pro-atherogenic mediators and subclinical atherogenesis are related to epicardial adipose tissue thickness in patients with cardiovascular risk

et al. 2016

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“…Intriguingly, despite the small sample size ( n = 14), Hobbs et al, [ 127 ] found that NO 3 − supplementation (beetroot bread) only reduced BP in patients who were both T allele carriers and had the G894T polymorphism in the eNOS gene. A more recent study examined the influence of the G894T polymorphism and NO 3 − therapy on mortality in chronic heart failure patients [ 146 ]. Somewhat at odds with the findings of Hobbs et al, [ 127 ], Azzam et al [ 146 ] found that NO 3 − therapy (source not specified) increased the risk of mortality in patients with the G894T polymorphism, and to a greater extent in G allele carriers, suggesting that NO 3 − therapy might increase mortality in advanced heart failure.…”

Section: Main Textmentioning

confidence: 99%

Dietary nitrate and population health: a narrative review of the translational potential of existing laboratory studies

Shannon

Easton

Shepherd

et al. 2021

BMC Sports Sci Med Rehabil

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Background Dietary inorganic nitrate (NO3−) is a polyatomic ion, which is present in large quantities in green leafy vegetables and beetroot, and has attracted considerable attention in recent years as a potential health-promoting dietary compound. Numerous small, well-controlled laboratory studies have reported beneficial health effects of inorganic NO3− consumption on blood pressure, endothelial function, cerebrovascular blood flow, cognitive function, and exercise performance. Translating the findings from small laboratory studies into ‘real-world’ applications requires careful consideration. Main body This article provides a brief overview of the existing empirical evidence basis for the purported health-promoting effects of dietary NO3− consumption. Key areas for future research are then proposed to evaluate whether promising findings observed in small animal and human laboratory studies can effectively translate into clinically relevant improvements in population health. These proposals include: 1) conducting large-scale, longer duration trials with hard clinical endpoints (e.g. cardiovascular disease incidence); 2) exploring the feasibility and acceptability of different strategies to facilitate a prolonged increase in dietary NO3− intake; 3) exploitation of existing cohort studies to explore associations between NO3− intake and health outcomes, a research approach allowing larger samples sizes and longer duration follow up than is feasible in randomised controlled trials; 4) identifying factors which might account for individual differences in the response to inorganic NO3− (e.g. sex, genetics, habitual diet) and could assist with targeted/personalised nutritional interventions; 5) exploring the influence of oral health and medication on the therapeutic potential of NO3− supplementation; and 6) examining potential risk of adverse events with long term high- NO3− diets. Conclusion The salutary effects of dietary NO3− are well established in small, well-controlled laboratory studies. Much less is known about the feasibility and efficacy of long-term dietary NO3− enrichment for promoting health, and the factors which might explain the variable responsiveness to dietary NO3− supplementation between individuals. Future research focussing on the translation of laboratory data will provide valuable insight into the potential applications of dietary NO3− supplementation to improve population health.

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“…Доказано, что уменьшение экспрессии и активности eNOS влечет за собой снижение синтеза и биодоступности NO и, следовательно, нарушает процессы вазодилатации и способствует развитию ЭД. Также к настоящему времени накоплено значительное количество работ, свидетельствующих об ассоциации полиморфизмов гена eNOS с развитием и прогрессированием ХСН [4].…”

Section: Introductionunclassified

Prognostic Significance of the VNTR Polymorphism Intron 4 of the Gene of Nitric Oxide Endothelial Synthase in Chronic Heart Failure Patients

Полунина¹,

Шварц²,

Севостьянова³

et al. 2018

Kardiovask. ter. profil.

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государственный медицинский университет" Минздрава России. Астрахань; 2 ФГБОУ ВО "Саратовский государственный медицинский университет имени В. И. Разумовского" Минздрава России. Саратов, Россия Цель. Проанализировать распространенность носительства VNTR-полиморфизма intron 4 (4b/4b и 4a/4b) гена эндотелиальной синтазы оксида азота (eNOS) у больных с хронической сердечной недостаточностью (ХСН) ишемического генеза в зависимости от фракции выброса левого желудочка (ФВ ЛЖ) и от стадии заболевания. Материал и методы. Обследованы 280 больных с ХСН, разделенных на группы в зависимости от ФВ ЛЖ (методом эхокардиографии) и стадии заболевания. Затем в ходе исследования у больных производили забор генетического материала с последующим типированием аллелей генов 4b/4b и 4a/4b полиморфизма гена eNOS. Результаты. По результатам анализа частоты распространения носительства 4b/4b и 4a/4b полиморфизма гена eNOS и частоты наличия ХСН различных стадий у носителей этих генотипов было установлено преобладание носителей генотипа 4a/4b у больных с IIА до III стадии заболевания как в группе больных с сохранной, так и со сниженной ФВ ЛЖ. Было выявлено повышение абсолютного риска и отношения шансов носительства генотипа 4а/4b у больных с ХСН IIБ-III стадии. Заключение. Установлена генетически-ассоциированная предрасположенность к прогрессированию ХСН у всех больных с носительством 4а/4b полиморфизма гена eNOS и протективная генетически-ассоциированная роль носительства 4b/4b полиморфизма гена eNOS. Ключевые слова: хроническая сердечная недостаточность, VNTRполиморфизм intron 4 гена эндотелиальной синтазы оксида азота.

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Endothelial nitric oxide synthase polymorphism and prognosis in systolic heart failure patients

Cited by 7 publications

References 57 publications

Pro-atherogenic mediators and subclinical atherogenesis are related to epicardial adipose tissue thickness in patients with cardiovascular risk

Pro-atherogenic mediators and subclinical atherogenesis are related to epicardial adipose tissue thickness in patients with cardiovascular risk

Dietary nitrate and population health: a narrative review of the translational potential of existing laboratory studies

Prognostic Significance of the VNTR Polymorphism Intron 4 of the Gene of Nitric Oxide Endothelial Synthase in Chronic Heart Failure Patients

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