Urinary biomarkers of oxidative and nitrosative stress and the risk for incident stroke: A nested case–control study from a community-based cohort

Lin, Hung‐Ju; Chen, Shu-Ting; Wu, Hon-Yen; Hsu, Hsiu-Ching; Chen, Ming-Fong; Lee, Yuan‐Teh; K, Wu; Chien, Kuo–Liong

doi:10.1016/j.ijcard.2015.01.043

Cited by 23 publications

(17 citation statements)

References 53 publications

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“…Thus, 14 studies ( 2 , 3 , 5 , 13 , 15 , 16 , 21 , 24 , 25 , 28 , 30 , 35 , 37 , 46 ) on 810 CVD patients and 1106 controls were included in the final analysis ( Supplementary Fig. S1 ).…”

Section: Resultsmentioning

confidence: 99%

“…S1 ). In detail, three studies on stroke (245 cases and 566 controls) ( 5 , 24 , 37 ), seven on CAD (351 cases and 404 controls) ( 2 , 3 , 13 , 21 , 28 , 30 , 46 ), two on patients with carotid atherosclerosis undergoing carotid endarterectomy (134 cases and 66 controls) ( 16 , 35 ), and two on peripheral artery disease (80 cases and 70 controls) ( 15 , 25 ) were included.…”

Section: Resultsmentioning

confidence: 99%

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8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature

Minno

Turnu

Porro

et al. 2016

Antioxidants & Redox Signaling

140

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Significance: 8-Hydroxy-2-deoxyguanosine (8-OHdG) is generated after the repair of ROS-mediated DNA damages and, thus, is one of the most widely recognized biomarkers of oxidative damage of DNA because guanosine is the most oxidized among the DNA nucleobases. In several pathological conditions, high urinary levels of oxidized DNA-derived metabolites have been reported (e.g., cancer, atherosclerosis, hypertension, and diabetes). Recent Advances: Even if published studies have shown that DNA damage is significantly associated with the development of atherosclerosis, the exact role of this damage in the onset and progression of this pathology is not fully understood, and the association of oxidative damage to DNA with cardiovascular disease (CVD) still needs to be more extensively investigated. We performed a meta-analysis of the literature to investigate the association among 8-OHdG levels and CVD. Critical Issues: Fourteen studies (810 CVD patients and 1106 controls) were included in the analysis. We found that CVD patients showed higher 8-OHdG levels than controls (SMD: 1.04, 95%CI: 0.61, 1.47, p < 0.001, I2 = 94%, p < 0.001). The difference was confirmed both in studies in which 8-OHdG levels were assessed in urine (MD: 4.43, 95%CI: 1.71, 7.15, p = 0.001) and in blood samples (MD: 1.42, 95%CI: 0.64, 2.21, p = 0.0004). Meta-regression models showed that age, hypertension, and male gender significantly impacted on the difference in 8-OHdG levels among CVD patients and controls. Future Directions: 8-OHdG levels are higher in patients with CVD than in controls. However, larger prospective studies are needed to test 8-OHdG as a predictor of CVD. Antioxid. Redox Signal. 24, 548–555.

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“…Thus, 14 studies ( 2 , 3 , 5 , 13 , 15 , 16 , 21 , 24 , 25 , 28 , 30 , 35 , 37 , 46 ) on 810 CVD patients and 1106 controls were included in the final analysis ( Supplementary Fig. S1 ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature

Minno

Turnu

Porro

et al. 2016

Antioxidants & Redox Signaling

140

View full text Add to dashboard Cite

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“…However, studies have found an increase in the oxidative stress‐induced 8‐isoprostaglandin F2α level in ischaemic stroke patients. A nested case‐control study shown that 8‐isoprostaglandin F2α is an independent predictor of acute stroke risk . In a report on aspirin resistance in stroke, it was noted that isoprostaglandins produced by the chemical lipid peroxidation pathway promote vasoconstriction and platelet aggregation, leading to aspirin resistance.…”

Section: Commentmentioning

confidence: 99%

Aspirin resistance mediated by oxidative stress‐induced 8‐Isoprostaglandin F2

2019

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Summary What is Known and Objective Aspirin resistance refers to a patient's poor response to aspirin. There are many factors that can contribute to aspirin resistance, including single‐nucleotide polymorphisms, medication compliance, drug‐drug interactions and inflammation. Comment Recently, oxidative stress‐induced 8‐isoprostaglandin F2α has attracted considerable attention because it is considered as a mechanism of aspirin resistance in many diseases, including coronary artery disease, neurology system disease, metabolic syndrome, cancer, chronic obstructive pulmonary disease and chronic kidney disease. In these diseases, increased oxidative stress may promote platelet activation and reduce the efficacy of aspirin by producing excessive amounts of 8‐isoprostaglandin F2α. What is New and Conclusion Given the wide clinical use of aspirin, it is essential to understand why some patients do not response to it. This article reviews current research on aspirin resistance mediated by oxidative stress‐induced 8‐isoprostaglandin F2α.

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“…Basically, nested case-control design is a type of case-control design nested in a cohort study. This study design has been widely used (Lin et al, 2015;Olsson et al, 2010;Sawada et al, 2010) due to its being able to control for long-term trend and seasonality by study design through matching, which is particular useful when studying time-varying exposure. The nested case-control design is a useful alternative to Cox regression to analyze time-varying exposure, due to similar risk estimates with superior computational efficiency (Essebag et al, 2005).…”

Section: The Nested Case-control Study Design and Dlnmmentioning

confidence: 99%

The influence of pre-existing health conditions on short-term mortality risks of temperature: Evidence from a prospective Chinese elderly cohort in Hong Kong

Sun

Tian

Qiu

et al. 2016

Environmental Research

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Urinary biomarkers of oxidative and nitrosative stress and the risk for incident stroke: A nested case–control study from a community-based cohort

Cited by 23 publications

References 53 publications

8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature

8-Hydroxy-2-Deoxyguanosine Levels and Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Literature

Aspirin resistance mediated by oxidative stress‐induced 8‐Isoprostaglandin F2

The influence of pre-existing health conditions on short-term mortality risks of temperature: Evidence from a prospective Chinese elderly cohort in Hong Kong

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