Urinary Biomarkers for Diagnosis and Prediction of Acute Kidney Allograft Rejection: A Systematic Review

Guzzi, Francesco; Cirillo, Luigi; Buti, Elisa; Becherucci, Francesca; Errichiello, Carmela; Roperto, Rosa Maria; Hunter, James; Romagnani, Paola

doi:10.3390/ijms21186889

Cited by 23 publications

(17 citation statements)

References 76 publications

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“…Today, urine tests and urinary cytology (UC) tests are used as the primary diagnostic markers of bladder cancer. Biochemical and molecular investigations of blood and urine make a liquid biopsy that could suggest new approaches for prevention, monitoring, and diagnosis [ 17 ]. Biomarkers are conceptions driven to present a sweeping landscape of a specific human biological system [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Aalami

Abdeahad

Mesgari

et al. 2021

BioMed Research International

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Aims. Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients’ urine with bladder neoplasm. Methods. We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10th October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR+), negative likelihood ratio (LR-), Q ∗ index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients. Results. Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66–0.75), specificity of 0.78 (95% CI: 0.73–0.81), LR+ of 3.34 (95% CI: 2.02–5.53), LR- of 0.37 (95% CI: 0.32–0.44), DOR of 9.99 (95% CI: 4.69–21.28), and AUC of 0.789 and Q ∗ index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa. Conclusion. This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients.

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Section: Introductionmentioning

confidence: 99%

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Aalami

Abdeahad

Mesgari

et al. 2021

BioMed Research International

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“…Another challenge in the clinical approach to kidney disease is the discovery of new tools for diagnosing and monitoring kidney disease that would be easily accessible with noninvasive procedures. In this context, urine represents a valuable biofluid due to its accessibility, fast and easy sampling and broad variety in proteins, metabolites, cells and cellular contents released from the urogenital tract [ 134 ]. The presence of cells in urine that display stem cell properties was first described by Zhang et al in 2008 [ 135 ].…”

Section: Outlook On the Future Of Renal Progenitorsmentioning

confidence: 99%

Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle?

Peired

Melica

Molli

et al. 2021

Cells

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Kidneys of mice, rats and humans possess progenitors that maintain daily homeostasis and take part in endogenous regenerative processes following injury, owing to their capacity to proliferate and differentiate. In the glomerular and tubular compartments of the nephron, consistent studies demonstrated that well-characterized, distinct populations of progenitor cells, localized in the parietal epithelium of Bowman capsule and scattered in the proximal and distal tubules, could generate segment-specific cells in physiological conditions and following tissue injury. However, defective or abnormal regenerative responses of these progenitors can contribute to pathologic conditions. The molecular characteristics of renal progenitors have been extensively studied, revealing that numerous classical and evolutionarily conserved pathways, such as Notch or Wnt/β-catenin, play a major role in cell regulation. Others, such as retinoic acid, renin-angiotensin-aldosterone system, TLR2 (Toll-like receptor 2) and leptin, are also important in this process. In this review, we summarize the plethora of molecular mechanisms directing renal progenitor responses during homeostasis and following kidney injury. Finally, we will explore how single-cell RNA sequencing could bring the characterization of renal progenitors to the next level, while knowing their molecular signature is gaining relevance in the clinic.

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“…Another challenge in the clinical approach to kidney disease is the discovery of new tools for diagnosing and monitoring kidney disease that would be easily accessible with noninvasive procedures. In this context, urine represents a valuable biofluid due to its accessibility, fast and easy sampling and broad variety in proteins, metabolites, cells and cellular contents released from the urogenital tract [134]. The presence of cells in urine that display stem cell properties was first described by Zhang et al in 2008 [135].…”

Section: Figurementioning

confidence: 99%

Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle?

Peired¹,

Melica²,

Molli³

et al. 2020

Preprint

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Kidneys of mice, rats and humans possess progenitors that maintain daily homeostasis and take part in endogenous regenerative processes following injury, owing to their capacity to proliferate and differentiate. In the glomerular and tubular compartments of the nephron, consistent studies demonstrated that well-characterized, distinct populations of progenitor cells, localized in the parietal epithelium of Bowman capsule and scattered in the proximal and distal tubules, could generate segment-specific cells in physiological conditions and following tissue injury. However, defective or abnormal regenerative responses of these progenitors can contribute to pathologic conditions. The molecular characteristics of renal progenitors have been extensively studied, revealing that numerous classical and evolutionarily conserved pathways, such as Notch or Wnt/β-catenin, play a major role in cell regulation. Others, such as retinoic acid, renin-angiotensin-aldosterone system, TLR2 (Toll-Like Receptor 2) and leptin, are also important in this process. In this review, we summarize the plethora of molecular mechanisms directing renal progenitor responses during homeostasis and following kidney injury. Finally, we will explore how single cell RNA sequencing could bring the characterization of renal progenitors to the next level, while knowing their molecular signature is gaining relevance in the clinic.

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Urinary Biomarkers for Diagnosis and Prediction of Acute Kidney Allograft Rejection: A Systematic Review

Cited by 23 publications

References 76 publications

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle?

Molecular Mechanisms of Renal Progenitor Regulation: How Many Pieces in the Puzzle?

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