Urinary Angiogenin as a Marker for Bladder Cancer: A Meta-Analysis

Abstract

Aims. Bladder cancer (BCa) is a common cancer in North America and Europe that carries considerable morbidity and mortality. A reliable biomarker for early detection of the bladder is crucial for improving the prognosis of BCA. In this meta-analysis, we examine the diagnostic role of the angiogenin (ANG) protein in patients’ urine with bladder neoplasm. Methods. We performed a systematic literature search using ScienceDirect, Web of Science, PubMed/MEDLINE, Scopus, Google Scholar, and Embase, up to 10th October 2020 databases. Meta-Disc V.1.4 and Comprehensive Meta-Analysis V.2.2 software calculated the pooled specificity, sensitivity, area under the curve (AUC), diagnostic odds ratio (DOR), positive likelihood ratio (LR+), negative likelihood ratio (LR-), Q ∗ index, and summary receiver-operating characteristic (SROC) for the role of ANG as a urinary biomarker for BCa patients. Results. Four case-control studies were included with 656 participants (417 cases and 239 controls) in this meta-analysis. The pooled sensitivity of 0.71 (95% CI: 0.66–0.75), specificity of 0.78 (95% CI: 0.73–0.81), LR+ of 3.34 (95% CI: 2.02–5.53), LR- of 0.37 (95% CI: 0.32–0.44), DOR of 9.99 (95% CI: 4.69–21.28), and AUC of 0.789 and Q ∗ index of 0.726 demonstrate acceptable diagnostic precision of ANG in identifying BCa. Conclusion. This meta-analysis showed that ANG could be a fair biomarker for the diagnosis of BCa patients.

Angiogenin Levels and Their Association with Cardiometabolic Indices Following Vitamin D Status Correction in Saudi Adults

“…ANG is a multifunctional protein known to induce blood vessel formation and is a potential biomarker for cardiac deterioration [20] and several types of cancers [24][25][26].…”

“…ANG is a multifunctional protein known to induce blood vessel formation and is a potential biomarker for cardiac deterioration [ 20 ] and several types of cancers [ 24 , 25 , 26 ]. Within this context, we studied the effects of improving vitamin D status in circulating ANG and whether it is associated with other known cardiometabolic indices in vitamin D-deficient adults.…”

Research progress on the structure, function, and use of angiogenin in malignant tumours

“…Thus, ANG may be a good diagnostic marker for monitoring the progression of BC [ 39 ]. A previous study on the diagnostic role of urinary ANG in patients with bladder tumours has reported a sensitivity of 0.71 (95 % CI: 0.66–0.75), specificity of 0.78 (95 % CI: 0.73–0.81), LR+ of 3.34 (95 % CI: 2.02–5.53), LR-of 0.37 (95 % CI: 0.32–0.44), DOR of 9.99 (95 % CI: 4.69–21.28), and AUC of 0.789 and Q∗ index of 0.726, indicating the diagnostic value of urinary ANG in identifying BC [ 52 ].…”

A Liquid Biopsy in Bladder Cancer—The Current Landscape in Urinary Biomarkers

“…For this reason, a meta-analysis [ 58 ] of ANG as a potential marker of BCa was performed. It showed a pooled sensitivity of 0.71, specificity of 0.78, and AUC of 0.789 ( Table 7 ), which gives a chance to use ANG in diagnosing BCa.…”