Urinary analysis of nephrolithiasis markers

Barbas, Coral; Garcı́a, Antonia; Saavedra, Luis Celi; Muros, Mercedes

doi:10.1016/s1570-0232(02)00557-3

Cited by 56 publications

(56 citation statements)

References 123 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This suggests that alkaline urine tends to precipitate magnesium, which may complex with ammonium and phosphate excreted in urine. Treatment with aqueous extract of Melia azadirachta reduced the pH values to 6.5−7.5 supporting the decrease in stone weight and urinary excretion of stone forming ions in antiurolithiatic study, indicating the influence of the extract in dissolving urinary calculi [17]. All this supports the effectiveness of the aqueous extract of Melia azadirachta against prevention of stone formation and its ability to dissolve preformed stones.…”

Section: Discussionsupporting

confidence: 63%

“…Quantitative analysis of the stones based on surface and weight indicated that the large stones formed were of magnesium ammonium phosphate (struvite) type with traces of calcium and oxalate [17].…”

Section: Resultsmentioning

confidence: 99%

“…The stones formed were of magnesium ammonium phosphate type with traces of calcium and oxalate [17].…”

Section: Discussionmentioning

confidence: 99%

“…Dissolution of calculi can be achieved by alteration in urinary pH . If the pH is acidic 5.0 or below, the stones likely to form are of uric acid type, if 5.0−6.5 calcium oxalate type and if alkaline (above 7) indicates crystals of magnesium ammonium phosphate [17].…”

Section: Discussionmentioning

confidence: 99%

“…The animal model of urolithiasis involving tubular dysfunction or injury by implantation of zinc disc in the urinary bladder of male albino rats to induce struvite stones [17]. It is also aimed to find out the influence of the plant extract on urinary electrolytes which play an important role in urolithiasis.…”

mentioning

confidence: 99%

See 4 more Smart Citations

A Study on Antiurolithiatic Activity of Melia Azadirachta L. Aqueous Extract in Rats

Hwisa¹,

Assaleh²,

Gindi³

et al. 2014

AJPS

View full text Add to dashboard Cite

The objective was to investigate the antiurolithiatic activity of aqueous plant extract of Melia azadirachta using the zinc disc implantation model in male Wistar albino rats. A significant increase in urinary excretion of calcium, oxalate, magnesium and phosphate was observed after four weeks of implantation of zinc discs. After treatment with aqueous extract of Melia azadirachta caused a significant reduction (p < 0.001) in stone weight and urinary excretion of electrolytes in both the preventive and curative group of animals as compared to those of control groups. This explains the effect of the aqueous extract of Melia azadirachta in preventing urolithiasis (59%) and dissolving the pre-formed magnesium ammonium phosphate type of stones (46%). The possible mechanism could be due to the urinary stone-formation, lowering, antioxidant, diuretic, nephroprotective constituents present in Melia azadirachta. These results suggest the usefulness of aqueous plant extract of Melia azadirachta as an antiurolithiatic agent.

show abstract

Section: Discussionsupporting

confidence: 63%

Section: Resultsmentioning

confidence: 99%

“…The stones formed were of magnesium ammonium phosphate type with traces of calcium and oxalate [17].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

A Study on Antiurolithiatic Activity of Melia Azadirachta L. Aqueous Extract in Rats

Hwisa¹,

Assaleh²,

Gindi³

et al. 2014

AJPS

View full text Add to dashboard Cite

show abstract

Capillary electrophoresis for short‐chain organic acids and inorganic anions in different samples

et al. 2003

View full text Add to dashboard Cite

This review article is a comprehensive survey of capillary electrophoresis methods developed for the measurement of short-chain organic acids and inorganic anions in a wide variety of matrices, such as food and beverages, environmental, industry, and other applications, as well as clinical applications in body fluids such as urine, plasma or cerebrospinal fluid. Details of sample pretreatment and of electrophoretic conditions have been collected in tables, arranged by the type of matrix. Strategies employed for method development for the analysis of these compounds by capillary electrophoresis in real samples are discussed.

show abstract

Micellar electrokinetic chromatographic and capillary zone electrophoretic methods for screening urinary biomarkers of human disorders: A critical review of the state‐of‐the‐art

et al. 2005

View full text Add to dashboard Cite

Human urine plays a central role in clinical diagnostic being one of the most-frequently used body fluid for detection of biological markers. Samples from patients with different diseases display patterns of biomarkers that differ significantly from those obtained from healthy subjects. The availability of fast, reproducible, and easy-to-apply analytical techniques that would allow identification of a large number of these analytes is thus highly desiderable since they may provide detailed information about the progression of a pathological process. From among the variety of methods so far applied for the determination of urinary metabolites, capillary electrophoresis, both in the capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC) modes, represents a robust and reliable analytical tool widely used in this area. The aim of the present article is to focus the interest of the reader on recent applications of MEKC and CZE in the field of urinary biomarkers and to discuss advantages and/or limitations of each mode.

show abstract

Urinary analysis of nephrolithiasis markers

Cited by 56 publications

References 123 publications

A Study on Antiurolithiatic Activity of <i>Melia </i><i>A</i><i>zadirachta</i> L. Aqueous Extract in Rats

A Study on Antiurolithiatic Activity of <i>Melia </i><i>A</i><i>zadirachta</i> L. Aqueous Extract in Rats

Capillary electrophoresis for short‐chain organic acids and inorganic anions in different samples

Micellar electrokinetic chromatographic and capillary zone electrophoretic methods for screening urinary biomarkers of human disorders: A critical review of the state‐of‐the‐art

Contact Info

Product

Resources

About