A Study on Antiurolithiatic Activity of &lt;i&gt;Melia &lt;/i&gt;&lt;i&gt;A&lt;/i&gt;&lt;i&gt;zadirachta&lt;/i&gt; L. Aqueous Extract in Rats

Hwisa, Nagiat T.; Assaleh, Fathi H.; Gindi, Sumalatha; Melad, Fauzi El; Chandu, Babu Rao; Katakam, Prakash

doi:10.12691/ajps-2-1-6

Cited by 8 publications

(7 citation statements)

References 21 publications

(23 reference statements)

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“…Renal calculi can be experimentally induced by either administration of various chemicals such as sodium oxalate or surgical implantation of foreign material like zinc disc in the urinary bladder of rats. The chemically-induced calculi model associated with high incidence of nephrotoxicity, metabolic acidosis, and occurrence of calculi in the renal cortex that is situation opposite to that found in human urolithiasis [20]. However, zinc disc model induces renal calculi with minimal renal damage and mimic the etiology of urinary stone formation in humans [21].…”

Section: Discussionmentioning

confidence: 96%

Anti-Urolithiatic Evaluation of Siddha formulation Seenakara Parpam against Zinc Disc Implantation induced Urolithiasis in Wistar Albino Rats

Mariappan¹,

Ganapathy²,

Banumathi³

2016

Int. J. Adv. Res. Biol. Sci

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Urolithiasis is one such disease that after extensive research in the field of urology has remained incurable in allopathy. It is a process of stone formation which occurs either in the kidney (commonly known as nephrolithiasis) and or in any part of the urinary tract, including the ureters (known as ureteral stone) and bladder (bladder stone). Urolithiasis has an important effect on the health care system with a prevalence of >10% and an expected recurrence rate of ∼50%.Siddha system of medicine is a source of treatment for many ailments. Some medicinal plants and proprietary composite herbal preparations are reported to be effective in the treatment as well as prevention of recurrence of renal calculi with minimal side effects. In Indian indigenous system of medicine, several formulations including Seenakara parpam are (SKP) claimed to be useful for the renal calculi but needs scientific documentation. The present investigation was aimed at evaluating the anti-urolithiatic activity of Seenakara parpam (SKP) on zinc disc implantation induced experimental urolithiasis on wistar albino rats. Implantation was carried out by a surgical procedure followed by the recovery period of three days. Soon after recovery animals were treated with SKP at the dose of 200 and 400 mg/kg b.wt, p.o. Animals belonging to standard group received cystone 500 mg/kg, p.o. for a period of 7 days. Parameters such as urine volume, urinary calcium output and calculi weight were measured at the end of the study. Treatment with SKP and cystone significantly reduced the excretion of calcium further the volume of urine output increased in treatment group when compared to that of the disc implanted group rats. Weight of the calculi is considered to be one of the important parameter in evaluating the efficacy of the drug. The results of the study clearly reflects that treatment with SKP at the dose of 200 and 400 mg/kg and standard drug cystone 500 mg/kg shown significant decrease in the weight of calculi from 113.5 mg to 10.5 mg. In conclusion formulations like SKP may be considered as a potential lead for the clinical management of urolithiasis.

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Section: Discussionmentioning

confidence: 96%

Anti-Urolithiatic Evaluation of Siddha formulation Seenakara Parpam against Zinc Disc Implantation induced Urolithiasis in Wistar Albino Rats

Mariappan¹,

Ganapathy²,

Banumathi³

2016

Int. J. Adv. Res. Biol. Sci

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“…The chemically-induced calculi model associated with high incidence of nephrotoxicity, metabolic acidosis, and occurrence of calculi in the renal cortex that is situation opposite to that found in human urolithiasis. [23] However, zinc disc model induces renal calculi with minimal renal damage and mimic the etiology of urinary stone formation in humans. [24] Therefore, zinc disc implantation-induced urolithiasis model was selected to induce urolithiasis in rats.…”

Section: Discussionmentioning

confidence: 99%

Antiurolithiatic activity of Abelmoschus moschatus seed extracts against zinc disc implantation-induced urolithiasis in rats

Pawar

Vyawahare²

2016

J Basic Clin Pharma

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Background:The commonly used techniques for removing renal calculi are associated with the risk of acute renal injury and increase in stone recurrence which indicates an urgent need for alternate therapy.Objectives:The aim was to evaluate the antiurolithiatic activity of Abelmoschus moschatus seed extracts in rats.Materials and Methods:Urolithiasis was induced by surgical implantations of zinc disc in the urinary bladders of rats. Upon postsurgical recovery, different doses of chloroform (CAM) and methanolic (MAM) extracts of A. moschatus seeds (viz., 100, 200 and 400 mg/kg body weight) were administered to disc implanted rats for the period of 7 days by the oral route. Antiurolithiatic activity was evaluated by measuring various dimensions of stones and estimating levels of various biomarkers in serum and urine samples.Results:A significant decrease in urinary output was observed in disc implanted animals, which was prevented by the treatment with extracts. Supplementation with extracts caused significant improvement in glomerular filtration rate and urinary total protein excretion. The elevated levels of serum creatinine, uric acid, and blood urea nitrogen were also prevented by the extracts. The extracts significantly reduced deposition of calculi deposition around the implanted disc. This antiurolithiatic potential is observed at all doses (100, 200, and 400 mg/kg) of MAM, whereas only higher dose (400 mg/kg) of CAM showed significant antiurolithiatic potential.Conclusion:The extracts of A. moschatus seeds possessed significant antiurolithiatic activity. The possible mechanism underlying this effect is mediated collectively through diuretic, antioxidant, and free-radical scavenging effects of the plant.

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“…The chemically-induced calculi model has their own limitations like high incidence of nephrotoxicity, metabolic acidosis and occurrence of calculi in renal cortex that is situation opposite as found in human urolithiasis. [ 12 ] However, zinc disc model induces renal calculi with minimal renal damage and mimic the etiology of urinary stone formation in humans. [ 13 ] Therefore, we evaluated the anti-urolithiatic potential of B. sensitivum using zinc disc implantation induced urolithiasis in rats.…”

Section: Discussionmentioning

confidence: 99%

Anti-urolithiatic activity of standardized extract of Biophytum sensitivum against zinc disc implantation induced urolithiasis in rats

Pawar¹,

Vyawahare²

2015

J Adv Pharm Technol Res

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Biophytum sensitivum (L.) DC (family: Oxalidaceae) has been used in the Indian indigenous system of medicine, Ayurveda, for the treatment of various health aliments including renal calculi. The present study was undertaken to investigate the anti-urolithiatic activity of standardized methanolic extract of whole plant of B. sensitivum (MBS) in rats. Urolithiasis was induced by surgical implantations of zinc disc in the urinary bladders of rats. Upon postsurgical recovery, different doses of MBS (viz., 100, 200, and 400 mg/kg body weight) were administered to zinc disc-implanted rats for the period of 7 days by the oral route. Anti-urolithiatic activity was evaluated by measuring various dimensions of stones and estimating levels of various biomarkers in serum and urine samples. A significant decrease in urinary output was observed in the disc-implanted animals, which was prevented by the MBS treatment. Supplementation with MBS caused significant improvement in glomerular filtration rate and protein excretion. The elevated levels of serum creatinine, uric acid, and blood urea nitrogen were also prevented by the MBS treatment. The MBS treatment showed reduced formation of deposition around the implanted zinc disc. The higher dose of MBS (400 mg/kg) found more effective. These results indicate that the administration of MBS significantly prevents the growth of urinary stones. The possible mechanism underlying this effect is mediated collectively through diuretic, antioxidant and anti-inflammatory effects of the plant. The results concluded that the methanolic extract of whole plant of B. sensitivum possessed significant anti-urolithiatic activity.

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A Study on Antiurolithiatic Activity of <i>Melia </i><i>A</i><i>zadirachta</i> L. Aqueous Extract in Rats

Cited by 8 publications

References 21 publications

Anti-Urolithiatic Evaluation of Siddha formulation Seenakara Parpam against Zinc Disc Implantation induced Urolithiasis in Wistar Albino Rats

Anti-Urolithiatic Evaluation of Siddha formulation Seenakara Parpam against Zinc Disc Implantation induced Urolithiasis in Wistar Albino Rats

Antiurolithiatic activity of Abelmoschus moschatus seed extracts against zinc disc implantation-induced urolithiasis in rats

Anti-urolithiatic activity of standardized extract of Biophytum sensitivum against zinc disc implantation induced urolithiasis in rats

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