Urinary 1‐hydroxypyrene and 8‐hydroxydeoxyguanosine Levels among Coke‐oven Workers for 2 Consecutive Days

Nguyen, Thi-To-Uyen; Kawanami, Satoshi; Kawai, Kazuaki; Kasai, Hiroshi; Li, Yun-Shan; Inoue, Jiro; Le, Ngoan Tran; Horie, Seichi

doi:10.1539/joh.13-0222-oa

Cited by 10 publications

(9 citation statements)

References 36 publications

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“…Urinary 1-OHP levels in occupational workers were higher than those of control population as suggested by Wenjuan et al [19] . These observations are also in accordance with those reported previously by Fu et al [20] and Nguyen et al [21] who described the toxicity of PAH as a consequence of imbalance between pro-oxidant and antioxidant homeostasis, the so called oxidative stress, which ultimately leads to oxidative damage. Therefore, to assess the differential impact of such toxicants on the exposed individuals, we investigated the association of genetic polymorphism of OGG1 gene with oxidative and genotoxic damage biomarkers in the exposed and control groups.…”

Section: Discussionsupporting

confidence: 93%

OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage

Miglani

Kumar

Yadav

et al. 2021

ibj

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Section: Discussionsupporting

confidence: 93%

OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage

Miglani

Kumar

Yadav

et al. 2021

ibj

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“…Considering this, B[a]P may also play an important role in estimating the health risk of coke oven workers. By measuring COE and B[a]P concentrations in different workplaces, we found that the side and top of the coke oven were the main sites of pollution, which were similar to the results of previous studies 9 , 27) . Our study also demonstrated that COE concentrations increased from the bottom to the top of the oven, and the concentration at the roof significantly exceeded that specified by OSHA (0.15 mg/m 3 ).…”

Section: Discussionsupporting

confidence: 89%

“…It has been widely studied that B[a]P is typically considered as a representative substance of PAHs (accounted for 10%-20%) 9) . Considering this, B[a]P may also play an important role in estimating the health risk of coke oven workers.…”

Section: Discussionmentioning

confidence: 99%

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Effects of coke oven emissions and benzo[a]pyrene on blood pressure and electrocardiogram in coke oven workers

Yang

Jiang

Cheng

et al. 2017

Journal of Occupational Health

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Objective: To evaluate the effects of occupational exposures to coke oven emissions (COEs) and benzo[a]pyrene (B[a]P) on the prevalence of hypertension and abnormal electrocardiogram (ECG) in coke oven workers.Methods: We included 880 coke oven workers and 710 oxygen employees in the exposed and control groups, respectively. Blood pressure (BP), ECG, blood lipid levels, and glucose levels of all subjects were measured. COE and B[a]P concentrations at the bottom, side, and top of the oven and control plants were estimated by weighing and high-performance liquid chromatography.Results: The COE concentration at the top and side was higher than that at the bottom (P < 0.05). The levels of B[a]P at the top and side significantly exceeded the limit value. Abnormal BP, ECG, the detection ratio of hypertension and left ventricular high voltage were significantly greater in the exposed group than in the control group (P < 0.05). The logistic regression analysis results revealed that age and B[a]P exposure were risk factors for hypertension in coke oven workers (P < 0.05) and both were risk factors for abnormal ECG (P < 0.05). Moreover, B[a]P exposure, age, and gender were risk factors for impaired fasting glucose in coke oven workers (P < 0.05).Conclusions: B[a]P and COE exposures are risk factors for hypertension and abnormal ECG in coke oven workers.

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“…4 Therefore, 1-OHP urinary level is widely used as a metabolite for biological monitoring of occupational exposure to PAHs among coke oven workers. 5,6 Coal tar contains benzo[a]pyrene (BaP), one of the most studied PAHs. It is a potent human immunosuppressive, pro-inflammatory and carcinogen agent.…”

Section: Introductionmentioning

confidence: 99%

Urinary and Genetic Biomonitoring of Polycyclic Aromatic Hydrocarbons in Egyptian Coke Oven Workers: Associations between Exposure, Effect, and Carcinogenic Risk Assessment

Samir

Shaker

Fathy

et al. 2019

Int J Occup Environ Med

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Background: Coke oven workers are exposed to polycyclic aromatic hydrocarbons (PAHs) with possible genotoxicity and carcinogenicity. Metabolizing enzymes genes and DNA repair genes are suspected to be correlated with the level of DNA damage. They may contribute to variable individual sensitivity to DNA damage induced by PAHs exposure at workplace. Objective: To investigate the relationship between biomarkers of PAHs: 1-hydroxypyrene (1-OHP), DNA adducts, and 8-hydroxy-2-deoxyguanosine (8-OHdG) in coke oven workers, and to assess the role of cytochrome P2E1 (CYP2E1) gene expression and DNA repairing gene (XRCC1) polymorphism in detecting workers at risk. Methods: 85 exposed workers and 85 unexposed controls were enrolled into this study. Urinary 1-OHP, 8-OHdG, and BPDE-DNA adduct were measured. CYP2E1 gene expression and genotyping of XRCC1 399 Arg/Gln were evaluated by real-time PCR. Results: The median urinary 1-OHP levels (6.3 µmol/mol creatinine), urinary 8-OHdG (7.9 ng/mg creatinine), DNA adducts (6.7 ng/μg DNA) in the exposed group were significantly higher than those in the unexposed group. Carriers of the variant allele (Gln) of XRCC1 had the highest levels of 1-OHP, DNA adducts and 8-OHdG, and the lowest level of CYP2E1 gene expression. In exposed workers, significant positive correlations were found between 1-OHP level and each of the work duration, 8-OHdG, and DNA adducts levels. There was a significant negative correlation between 1-OHP level and CYP2E1 gene expression. Work duration and CYP2E1 gene expression were predictors of DNA adducts level; 1-OHP level and work duration were predictors of urinary 8-OHdG level. Conclusion: Workers with higher exposure to PAH were more prone to oxidative DNA damage and cancer development. DNA adducts level reflects the balance between their production by CYP2E1 and elimination by XRCC1 gene.

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Urinary 1‐hydroxypyrene and 8‐hydroxydeoxyguanosine Levels among Coke‐oven Workers for 2 Consecutive Days

Cited by 10 publications

References 36 publications

OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage

OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage

Effects of coke oven emissions and benzo[a]pyrene on blood pressure and electrocardiogram in coke oven workers

Urinary and Genetic Biomonitoring of Polycyclic Aromatic Hydrocarbons in Egyptian Coke Oven Workers: Associations between Exposure, Effect, and Carcinogenic Risk Assessment

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