Uric Acid Metabolism in Children

Baldree, Lou Anne; Stapleton, F. Bruder

doi:10.1016/s0031-3955(16)36876-6

Cited by 75 publications

(62 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hidrasi diberikan secara intravena dengan cairan 5% glukosa dan 0,225% natrium sebanyak 2-4 kali kebutuhan rumatan perhari, 7-10 selama 24 jam; bila memungkinkan dapat dilanjutkan 18-45 jam sebelum pemberian kemoterapi 19 …”

Section: Tata Laksanaunclassified

See 1 more Smart Citation

Pengaruh Metabolit Tumor Akibat Sindrom Tumor Lisis pada Terjadinya Gagal Ginjal Akut Serta pada Anak

Hariweni

2016

View full text Add to dashboard Cite

Sindrom tumor lisis merupakan triad kelainan metabolik (hiperurisemia, hiperfosfatemia,hiperkalemia) yang sering terjadi pada pasien keganasan akibat sel-sel tumor lisis secaracepat baik secara spontan ataupun karena pengobatan anti kanker. Metabolit tumor(asam urat, fosfor, kalium) semuanya diekskresi oleh ginjal sehingga sering menimbulkankomplikasi pada ginjal. Komplikasi tersering adalah gagal ginjal akut, hal ini memerlukanperhatian yang serius karena lebih mudah dicegah daripada diobati.

show abstract

Section: Tata Laksanaunclassified

“…Setelah hidrasi dan alkalinisasi segera diberikan allopurinol dengan dosis 100 mg/M 2 /kali setiap 8 jam secara oral 1,10,19 atau secara intravena dengan dosis 200mg/M2/hari, 9 karena allopurinol dan metabolitnya yaitu oksipurinol merupakan inhibitor yang kuat terhadap xantin oksidase, enzim yang mengubah hipoxantin dan xantin menjadi asam urat.…”

unclassified

Pengaruh Metabolit Tumor Akibat Sindrom Tumor Lisis pada Terjadinya Gagal Ginjal Akut Serta pada Anak

Hariweni

2016

View full text Add to dashboard Cite

show abstract

“…At higher concentrations, blood plasma becomes supersaturated, thus, uric acid will precipitate and uric crystals formed. Normally, UA is formed by the body as much as 400 mg/day, while uric acid obtained from food reaches 300 mg/day [2]. However, when UA levels in the body exceed normal limits, it tends to build up and leads to hyperuricemia (HUA).…”

Section: Introductionmentioning

confidence: 99%

Green Tea Extract (Camellia sinensis L.) Effects on Uric Acid Levels on Hyperuricemia Rats (Rattus norvegicus)

Nugraheni

Rahmawati

Mahdi

et al. 2017

J. Pure App. Chem. Res.

View full text Add to dashboard Cite

Uric acid is the end product of purine degradation. When uric acid levels exceed normal limits, it will build up and cause hyperuricemia. Allopurinol is one of the most effective and common medicine for hyperuricemia, but it brings serious side effects, therefore it is needed alternative therapy for hyperuricemia. One plant that may be expected to low uric acid levels is green tea (Camellia sinensis L.), that contains many antioxidants polyphenols, especially flavonoids. Flavonoid has strong antioxidant properties, act as free radical and metal scavengers, and also xanthine oxidase (XOD) inhibitors. This study investigates the potential of green tea using various doses of 150 mg/kg, 300 mg/kg, and 600 mg/kg of body weight in 24 white male rats (Rattus norvegicus) Wistar strain that has been received high purine diet in 60 consecutive days. This study used DHBSA methods to measure uric acid levels in blood serum and urine that excreted 8 hours before surgery. Green tea extract that contains polyphenol can inhibit XOD activities, therefore, it leads to decrease uric acid level in blood and increase the excretion through urine by modulating urate gene transporter. A therapy with 600 mg/kg body weight of GTE is the most effective dose to decrease uric acid levels in serum and to increase excretion of exceeding uric acid significantly (p < 0.01), from One Way ANOVA and Tukey analysis.

show abstract

“…Hyperuricemia, in adults, is defined as having a plasma uric acid level of greater than 7 mg/dl [8]. The frequency of hyperuricemia varies worldwide, ranging from 8% in Saudi Arabia to 35.2% in Seychelles [9,10].…”

Section: Introductionmentioning

confidence: 99%

Hyperuricemia and Urologic Disease

Cho

Min

2017

Urogenit Tract Infect

View full text Add to dashboard Cite

Gout is a disease that causes painful inflammatory arthritis related to hyperuricemia, due to the incorrect metabolism of uric acid. Decreased renal excretion of urate is thought to be the major hyperuricemic mechanism. Most genes responsible for the serum uric acid (SUA) level encode uric acid transporters or related regulatory proteins. The acquired effects can also modulate SUA level and uric acid excretion, which can result in acute gout. Interestingly, kidney related comorbidities in gout, such as hypertension, chronic kidney disease (CKD), and urolithiasis, all have a fairly high prevalence. Recent advancements in genetics and molecular physiology have greatly improved our understanding of renal reabsorption and secretion of filtered uric acid. Furthermore, the baseline SUA level appears to be established by a net balance between absorption and secretion through the epithelium of the kidneys and intestines. There have also been considerable progress in the management of gout patients with CKD. Increased prevalence of gout with CKD can be balanced by an expanded spectrum of treatment options for this important disease. Another issue is that lowering of the uric acid level can reduce the incidence of cardiovascular disease, renal disease, and urological complications. Basic research and clinical studies on these mechanisms might be helpful in determining the appropriate treatment for hyperuricemic patients. Based on currently existing literature, there have been improvements associated with medications that lower uric acid, particularly xanthine oxidase inhibitors. Here, we review the pathogenesis and epidemiology of hyperuricemia, specific diseases related to uric acid, and up-to-date perspectives on their management.

show abstract

Uric Acid Metabolism in Children

Cited by 75 publications

References 148 publications

Pengaruh Metabolit Tumor Akibat Sindrom Tumor Lisis pada Terjadinya Gagal Ginjal Akut Serta pada Anak

Pengaruh Metabolit Tumor Akibat Sindrom Tumor Lisis pada Terjadinya Gagal Ginjal Akut Serta pada Anak

Green Tea Extract (Camellia sinensis L.) Effects on Uric Acid Levels on Hyperuricemia Rats (Rattus norvegicus)

Hyperuricemia and Urologic Disease

Contact Info

Product

Resources

About