Uric Acid Levels Increase Risk for New-Onset Kidney Disease

Mohandas, Rajesh; Johnson, Richard J.

doi:10.1681/asn.2008091012

Cited by 30 publications

(27 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some investigators suggested that the histological findings revealed in renal biopsy specimens in patients with HUA such as tubulointerstitial fibrosis, arteriosclerosis, and glomerulosclerosis were similar with those observed in hypertensive renal disease. 45 These non-specific alterations were also present in advanced age or in patients with asymptomatic HUA. Moreover, given that patients with HUA are usually hypertensive, it is difficult to attribute such non-specific lesions to UA or to hypertension.…”

Section: Gouty Nephropathy and Ckdmentioning

confidence: 92%

“…Moreover, the independence of a risk factor is not necessarily equal to causality and a risk factor may be independent and not causal, when the real causal parameter is not included in the statistical analysis. 45 In the same way, a risk factor may be not independent but it could still be causal. 45 It could be assumed that HUA is an indirect cause of kidney disease, but the difficulty to clarify the role of UA as an independent risk factor for CKD is mainly due to the complex correlations and interactions between UA and conventional risk factors for CKD.…”

Section: Introductionmentioning

confidence: 99%

“…45 In the same way, a risk factor may be not independent but it could still be causal. 45 It could be assumed that HUA is an indirect cause of kidney disease, but the difficulty to clarify the role of UA as an independent risk factor for CKD is mainly due to the complex correlations and interactions between UA and conventional risk factors for CKD. However, the elucidation of the relationship between UA and CKD progression remains an evolving area of research.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Hyperuricemia and chronic kidney disease: an enigma yet to be solved

et al. 2014

View full text Add to dashboard Cite

The role of uric acid (UA) on the pathogenesis and progression of chronic kidney disease (CKD) remains controversial. Experimental and clinical studies indicate that UA is associated with several risk factors of CKD including diabetes, hypertension, oxidative stress, and inflammation and hyperuricemia could be considered as a common dominator linking CKD and cardiovascular disease. Notably, the impact of serum UA levels on the survival of CKD, dialysis patients, and renal transplant recipients is also a matter of debate, as there are conflicting results from clinical studies. At present, there is no definite data whether UA is causal, compensatory, coincidental or it is only an epiphenomenon in these patients. In this article, we attempt to review and elucidate the dark side of this old molecule in CKD and renal transplantation.

show abstract

Section: Gouty Nephropathy and Ckdmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hyperuricemia and chronic kidney disease: an enigma yet to be solved

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Numerous studies have confirmed that hyperuricemia is an independent risk factor for chronic kidney disease (CKD) and cardiovascular disease (CVD) [1,2,3,4]. Therefore, investigating ways to control serum uric acid levels has become a topic of great interest.…”

Section: Introductionmentioning

confidence: 99%

Smilacis Glabrae RhizomaReduces Oxidative Stress Caused by Hyperuricemia via Upregulation of Catalase

Hong

Yu²,

Mei³

et al. 2014

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Reports have suggested that the traditional Chinese medicine Smilacis Glabrae Rhizoma attenuates hyperuricemia, but its mechanism is unclear. Our previous study demonstrated that uric acid could induce the generation of reactive oxygen species(ROS), which subsequently cause endothelial dysfunction. Therefore, we focused on the oxidative stress process. In this study, we would use LC-MS and bioinformatic analysis to investigate the underlying mechanism. Methods: We utilized LC-MS to reveal the differential protein expression in the kidneys of rats in the hyperuricemia group and the Smilacis Glabrae Rhizoma treatment group and then subjected the differentially expressed proteins to bioinformatic analysis. We also determined the serum ROS level of the two groups. According the above results, we built our hypothesis and performed in vitro experiments to validate this hypothesis. Results: We found that catalase was upregulated in the group treated with Smilacis Glabrae Rhizoma, and the level of reactive oxygen species was higher in the hyperuricemia group. Thus, we speculated that Smilacis Glabrae Rhizoma could alleviate oxidative stress by upregulating catalase. In vitro experiments, we found that high concentrations of uric acid reduced catalase expression in endothelial cells, which was alleviated by Smilacis Glabrae Rhizoma and resulted in a reduction of reactive oxygen species. Knockdown of catalase led to an increase in reactive oxygen species. Conclusion: We demonstrated that Smilacis Glabrae Rhizoma could alleviate the oxidative stress caused by hyperuricemia by upregulating catalase expression. This finding could represent a new application for Smilacis Glabrae Rhizoma in the treatment of hyperuricemia.

show abstract

“…Hyperuricemia, which is strongly associated with obesity and MetS and nephropathy can predict visceral obesity and insulin resistance, might be partially responsible for the pro-inflammatory endocrine imbalance in the adipose tissue, which is an underlying mechanism of the lowgrade inflammation and insulin resistance in subjects with the MetS [60][61][62][63][64][65]. Gout is a common metabolic disorder, involving the liver, kidney, and joints; it is met more often in men, and is characterized by the deposition of reversible monosodium urate (MSU) crystals and occurs as a consequence of hyperuricemia which induces inflammatory arthritis and nephropathy.…”

Section: Mets Hyperuricemia and Nephropathymentioning

confidence: 99%

Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model—comparative study

et al. 2017

View full text Add to dashboard Cite

Background Worldwide obesity spread is a global health problem and needs to be further studied. Co-morbidities of obesity include insulin resistance, diabetes mellitus type 2, and dyslipidemia, which are the most frequent contributing factors for metabolic syndrome (MetS), as well as nonalcoholic fatty liver disease and chronic kidney disease. The aim was to study renal function and endogenous intoxication panel on high-calorie diet-induced obesity rat model and perform comparative study of the treatment efficacy of Fenugreek-based bionanocomposite vs antiobesogenic drugs (Orlistat). Materials We included 60 male rats and equally divided them to 6 groups of 10 animals in each group: the experimental groups were firstly assigned as controls and high caloric diet (HCD)-fed groups, and each group further was subdivided to remain untreated, Fenugreek bionanocomposite (BNC)-treated, and Orlistat-treated. Normal control rats (groups 1, 2, 3) were fed by a standard chow, while the others (groups 4, 5, 6) were fed with HCD ad libitum during 98 days. From days 77 to 98, groups 2 and 5 were treated with BNC based on Fenugreek (150 mg/kg body weight, orally) and groups 3 and 6 were treated with antiobesogenic drug Orlistat (10 mg/kg body weight, orally). Food and water consumptions were measured daily and body weights were measured once a week. On day 99, blood was collected; the creatinine, urea, and uric acid were estimated in serum according to the standard protocols. Levels of low and middle molecules (MMs) were measured; the quantity of oligopeptides was estimated by Bradford method. We performed the liver and kidney ultrasonography in rats.Results We revealed an increase in the levels of endogenous intoxication syndrome markers (MM and oligopeptides) in all animals with experimental obesity. Ultrasound data showed injury of the liver and kidneys in obese rats. We observed significant decreasing of MM levels after Orlistat treatment vs controls (p < 0.05). However, this effect was more pronounced in Fenugreek BNC-treated group vs both Orlistattreated and controls (p < 0.05). Orlistat treatment evoked rising of serum creatinine and oligopeptides in control animals

show abstract

Uric Acid Levels Increase Risk for New-Onset Kidney Disease

Cited by 30 publications

References 18 publications

Hyperuricemia and chronic kidney disease: an enigma yet to be solved

Hyperuricemia and chronic kidney disease: an enigma yet to be solved

Smilacis Glabrae RhizomaReduces Oxidative Stress Caused by Hyperuricemia via Upregulation of Catalase

Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model—comparative study

Contact Info

Product

Resources

About