Uric acid: is it time to give up routine testing in management of pre-eclampsia?

Talaulikar, Vikram; Shehata, Hassan

doi:10.1258/om.2011.110075

Cited by 12 publications

(14 citation statements)

References 54 publications

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“…The remaining seventy-nine pregnant women without pregnancy complications were studied as control group. This initial drop is due touricosuric effect of estrogen, expanded blood volume and increased glomerular filtration rate [10] and the rise in late pregnancy may be secondary to increased fetal production, decreased binding to albumin and increased tubular reabsorption [24]. In the present study, a significant increase of uric acid levels from first trimester (2.01 ± 0.85) to second trimester of pregnancy (4.8 ± 1.93) was noticed.…”

Section: Discussionsupporting

confidence: 55%

Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

Gadde¹,

Doddaiah²,

Rangappa³

2018

OJOG

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Preeclampsia is a pregnancy complication; early identification with increased risk is one of the key goals in obstetrics. In a nested case control study, serum uric acid and calcium measured in first and second trimesters of pregnancy were correlated with Xanthine oxidase (XO) activity, mean arterial pressure (MAP) and fetal birth weight. The mean ± SD of uric acid (2.01 ± 0.85, 4.8 ± 1.93), calcium (10.88 ± 1.97, 9.72 ± 2.04), MAP (84.32 ± 6.71, 78.40 ± 8.53) and XO activity (11.96 ± 1.91, 14.05 ± 3.09) of the study group (n=86) were observed in the first and second trimesters respectively. First trimester normotensive group (n=79) and preeclampsia cases (n = 7), showed a mean ± SD of uric acid (1.93 ± 0.80, 2.9 ± 0.88), Calcium (10.92 ± 1.9, 10.6 ± 1.72), MAP (84.19 ± 6.75, 85.71 ± 6.58) XO activity (11.82 ± 1.83, 13.57 ± 2.21). In the second trimester, normotensive group and preeclampsia cases showed a mean ± SD uric acid (4.6 ± 1.75, 7.3 ± 2.19), Calcium (9.4 ± 1.85, 12.9 ± 1.04), MAP (76.41 ± 5.41, 100.95 ± 2.52) and XO activity (13.37 ± 1.93, 21.70 ± 3.50). Statistical analysis revealed a non-significant positive correlation in first trimester between uric acid and MAP (r = +0.116, p = 0.288), negative correlations between uric acid and fetal birth weight (r = −0.118, 0.279) and between calcium and MAP (r = −0.288, p = 0.007). In the second trimester, significant positive correlations were observed between uric acid (r = +0.246, p = 0.022), calcium (r = +0.326, p = 0.007) with MAP along with a significant negative correlation between uric acid (r = −0.641, p = 0.000), calcium (r = −0.316, p = 0.003), Proteinuria (r = −0.514, p = 0.000) with fetal birth weight. The screening of first and second trimesters XO activity, uric acid, calcium and MAP during pregnancy is beneficial in identifying women likely to develop

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Section: Discussionsupporting

confidence: 55%

Relationship between Mean Arterial Pressure, Uric Acid and Calcium with Xanthine Oxidase Activity and Fetal Outcome in Normotensive and Preeclampsia in a Nested Study

Gadde¹,

Doddaiah²,

Rangappa³

2018

OJOG

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“…Foetal outcome is directly related to the maturation of placenta. Compromised placental perfusion from uterine vasospasm, a major culprit in the genesis of increased perinatal morbidity and mortality associated with pregnancy induced hypertension [2]. Abnormalities of placenta and umbilical cord are the most culpable cause of abnormal foetal outcome and even death.…”

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confidence: 99%

“…The perinatal outcomes of pregnant women with heart disease in Okayama University Hospital and towards the future Jota Maki Department of Obstetrics and Gynecology, Okayama University Graduate School Of Medicine, Okayama, Japan, 2 Department of Cardiovascular Surgery, Okayama University, Okayama, Japan Purpose: The number of pregnant women with adult congenital heart disease (ACHD) has been increased due to the improving prognosis of ACHD. Management of these patients has become an important problem in Obstetrics.…”

mentioning

confidence: 99%

“…Sleep changes during pregnancy in mice Haruna Komiya 1,2 , Chika Miyoshi 2 , Hiromi Hamada 1 , Toyomi Satoh 1 , Hiromasa Funato 2 , Masashi Yanagisawa 2 1 Department of Obstetrics and Gynecology, Faculty of Medicine, Tsukuba University, Tsukuba, Japan, 2 International Institute for Integrative Sleep Medicine(WPI-IIIS), Tsukuba University, Tsukuba, Japan Aim: Although it is known that sleep disturbance occurs due to the physiological and hormonal changes during human pregnancy, there have been few studies on sleep/wakefulness behaviors in pregnant mice. Since mice are used as research models for human health and diseases, it is crucial to elucidate how sleep/wakefulness behaviors in mice change as the pregnancy progresses.…”

mentioning

confidence: 99%

“…The causes of sepsis after caesarеan section Narantsatsralt Dagshinjav 1 , Jargalsaikhan Badarch 2 , Lkhagvasuren Jav 2 , Naran Gurjav 2 1 Urguu Maternity Hospital, Ulaanbaatar, Mongolia, 2 Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia Introduction: Post-Caesarean sepsis incidence rate is above 20%. An assortment of pathologic agents may cause puerperal infection including bacteria, virus and parasites.…”

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confidence: 99%

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Maternal Medicine

2017

J of Obstet and Gynaecol

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Introduction: In 2014, the International Society for the Study of Hypertension in Pregnancy (ISSHP) revised the definition of preeclampsia(PE). However, there is no report on the incidence of PE superimposed on chronic hypertension without proteinuria, which is not mentioned in the conventional diagnostic criteria, as well as pregnancy outcomes. Objective: We aimed to evaluate the validity of the diagnostic criteria for PE superimposed on chronic hypertension without requiring proteinuria. Methodology: This retrospective study included 142 women with essential hypertension diagnosed at ≤20 weeks of gestation, managed at a tertiary center. They were divided into three groups (non-PE group; PE with proteinuria group; and PE without proteinuria group) to compare pregnancy outcomes. The non-PE group was further divided into two subgroups (controlled and uncontrolled hypertension subgroups) Results: There were 87 women in the non-PE group, 47 in the PE with proteinuria group, and 8 in the PE without proteinuria group. Median gestational age at delivery was 38.7 weeks in the non-PE group, 30.4 in the PE with proteinuria group, and 28.4 in the PE without proteinuria group. In three of the eight women in the PE without proteinuria group, the condition fulfilling the diagnostic criteria was liver involvement (complicated by thrombocytopenia in one woman). Although the remaining five women had uteroplacental dysfunction, the validity of their PE diagnosis was questionable because their blood pressure was well controlled throughout pregnancy. The 87 women in the non-PE group were divided into a controlled hypertension subgroup of 75 women and uncontrolled hypertension subgroup of 12. In the uncontrolled HT subgroup, the pregnancy outcomes were significantly poorer than those in the controlled HT subgroup. Conclusion: Although exclusion of proteinuria from the essential diagnostic criteria for PE superimposed on chronic hypertension is valid, the criteria might need to include uncontrolled hypertension instead of uteroplacental dysfunction. 0020Maternal magnesium sulfate treatment and infant outcomes Ting-Chun Lai, Chi-Yuan Liao Mennonite Christian Hospital, Hualien, Taiwan Introduction: To prevent risk of the sometimes fatal complications of preeclampsia, magnesium sulfate is the recommended drug of choice for both prevention and treatment of eclampsia. Risk to infants from maternal magnesium sulfate exposure remains unclear, however, as earlier studies found an association with increased admission to neonatal intensive care and special care units, while more recent studies have found no associated risk of intensive resuscitation and other adverse neonatal outcomes. Objectives: Our study aims to elucidate the association between maternal magnesium sulfate exposure and neonatal risk. Methodology: This 12-year retrospective cohort included women diagnosed with preeclampsia who delivered at >=37 weeks' gestation. Women who received treatment with magnesium sulfate were categorized into the exposure group and all others into t...

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