Uric Acid is an Important Predictor for Hypertensive Early Atherosclerosis

Mutluay, Rüya; Deger, Serpil Muge; Bahadir, Eylem; Durmaz, Alim Ozgur; Çıtıl, Rıza; Sindel, Şükrü

doi:10.1007/s12325-012-0006-z

Cited by 30 publications

(19 citation statements)

References 41 publications

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“…Surrogate markers of atherosclerosis shown to have an association with hyperuricemia include carotid intima-media thickness (C-IMT) [11, 32–36], ankle brachial index [34], coronary artery calcification [37], and brachial-ankle pulse wave velocity (baPWV) [38]. In addition, many studies suggest an independent effect of elevated serum uric acid on atherosclerosis as measured by these surrogate markers after adjusting for the influence of metabolic syndrome and other factors [11, 33, 35, 39]. In particular, there is evidence that uric acid has direct effects on key processes involved in endothelial function and vascular remodeling [40].…”

Section: Hyperuricemia and Atherosclerosismentioning

confidence: 99%

“…For example, hypertensive hyperuricemic patients have higher levels of BMI, C-IMT, fasting plasma glucose, UA, hs-CRP, and proteinuria as compared with hypertensive normouricemic subjects. Hyperuricemia, per se , was found to be an independent predictor for atherosclerosis in patients with hypertension [33]. In another clinical study, serum uric acid was found to be associated with subclinical atherosclerosis in men with type II diabetes mellitus [34, 49].…”

Section: Hyperuricemia and Atherosclerosismentioning

confidence: 99%

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Review of Hyperuricemia as New Marker for Metabolic Syndrome

et al. 2014

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Hyperuricemia has long been established as the major etiologic factor in gout. In recent years, a large body of evidence has accumulated that suggests that hyperuricemia may play a role in the development and pathogenesis of a number of metabolic, hemodynamic, and systemic pathologic diseases, including metabolic syndrome, hypertension, stroke, and atherosclerosis. A number of epidemiologic studies have linked hyperuricemia with each of these disorders. In some studies, therapies that lower uric acid may prevent or improve certain components of the metabolic syndrome. There is an association between uric acid and the development of systemic lupus erythematosus; the connection between other rheumatic diseases such as rheumatoid arthritis and osteoarthritis is less clear. The mechanism for the role of uric acid in disorders other than gout is not well established but recent investigations point towards systemic inflammation induced by urate, as the major pathophysiological event common to systemic diseases, including atherosclerosis.

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Section: Hyperuricemia and Atherosclerosismentioning

confidence: 99%

Section: Hyperuricemia and Atherosclerosismentioning

confidence: 99%

Review of Hyperuricemia as New Marker for Metabolic Syndrome

et al. 2014

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“…The carotid intima-media thickness (CIMT), assessed noninvasively using ultrasonography, has been validated to be a sensitive marker of atherosclerosis and is directly associated with an increased risk of cardiovascular disease 10) . Previous studies have shown the uric acid level to be positively associated with the CIMT in various specific populations, including patients with hypertension 11) or diabetes mellitus 12) and postmenopausal women 13) . However, limited data are available regarding the relationship between the uric acid level and CIMT in the general population.…”

Section: Questionnaire Data and Biochemical Measurementsmentioning

confidence: 99%

Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese

Chen

Sun

et al. 2015

JAT

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Aim:The carotid intima-media thickness (CIMT) is now validated as a sensitive marker of atherosclerosis and is directly associated with an increased risk of cardiovascular disease. Considering that the independent association between the serum uric acid level and CIMT remains controversial due to the complex interrelationship with other known cardiovascular risk factors, further studies are needed. The aim of the present study is to explore the association between the serum uric acid level and CIMT in a general Chinese population and determine whether the association differs according to varied metabolic status. Methods: The present study was cross-sectional in design. A total of 10,281 community-based participants 40 years of age or older from Shanghai, China were included in the current analysis. All participants underwent a detailed questionnaire interview, anthropometric measurements and ultrasonography to assess the CIMT. Blood and urine samples were collected for the biochemical measurements. Results: The serum uric acid levels were positively associated with obesity-and diabetes-related parameters and the CIMT. In a logistic regression model controlling for potential confounders, compared with the participants in the first quartile of the uric acid level, those in the fourth quartile had a higher odds of an elevated CIMT in both men (odds ratio [OR] 1.37; 95% confidence interval [CI] 1.07-1.75) and women (OR 1.48; 95% CI 1.12-1.94). The subgroup analyses revealed that an association between an elevated CIMT and the serum uric acid level persisted regardless of diuretic use and the hypertension, diabetes mellitus and chronic kidney disease status. However, the association disappeared in the patients who consumed alcohol and in premenopausal women. Conclusions: The serum uric acid level is positively associated with an elevated CIMT in middleaged and elderly Chinese subjects, independent of known risk determinants of cardiovascular disease. J Atheroscler Thromb, 2015; 22: 823-832.

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“…Исследование риска развития атеросклероза (исследование ARIC) [21] показало, что уровень МК в значительной степени предопределяет увеличение толщины интима-медиа сонных артерий при проведении ультразвукового исследования. Впоследствии R. Mutluay et al (2012) сообщили, что гиперурикемия является независимым предиктором раннего атеросклероза у гипертоников с нормальной функцией почек [22]. Аналогичные результаты атерогенной роли МК в патофизиологии ССЗ были получены A.F.…”

Section: гиперурикемия и повреждение органов-мишенейunclassified

Подагра, Кардиоваскулярные Риски И Сердечно-Сосудистые Заболевания: Кристаллическая Неразбериха

Golovach¹,

Yehudіna

Ханюков

2021

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Согласно множеству проведенных исследований подагра ассоциирована с риском развития сердечно-сосудистых заболеваний и смерти, но патогенетическая связь между этими состояниями остается не до конца детерминирована. Снижение частоты возникновения кардиоваскулярных событий при соответствующем лечении подагры свидетельствует о причинной роли этой патологии при сердечно-сосудистых заболеваниях. В обзоре рассмотрены последние исследования, посвященные взаимосвязи подагры и патологии сердечно-сосудистой системы. Исследования противоречивы: некоторые утверждают, что снижение уровня мочевой кислоты в сыворотке приводит к уменьшению риска возникновения кардиоваскулярных событий, в то время как другие не демонстрируют таких преимуществ контроля гиперурикемии. Несоответствия в дизайне исследований могут способствовать этим вариациям в результатах. Кроме того, различные стратегии лечения подагры могут повлиять на возникновение и прогрессирование заболеваний сердечно-сосудистой системы. Несмотря на значительное количество исследовательских данных, полученных за последние 15 лет, остается неясным, есть ли польза для сердечно-сосудистой системы в применении гипоурикемической терапии при подагре. Кроме того, необходимы дальнейшие исследования, чтобы уточнить преимущества тех или иных препаратов, снижающих уровень уратов, в уменьшении сердечно-сосудистых рисков. Препараты, не влияющие на уровень мочевой кислоты, но применяющиеся у пациентов с подагрой, такие как колхицин и статины, также могут улучшать исходы кардиоваскулярной патологии в этой популяции пациентов.

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Uric Acid is an Important Predictor for Hypertensive Early Atherosclerosis

Abstract: Hyperuricemia is an independent predictor for early atherosclerosis in hypertensive subjects with normal renal function. Therefore, the optimal control of UA may provide further benefits in preventing atherosclerosis and hypertensive end-organ injury.

Cited by 30 publications

References 41 publications

Review of Hyperuricemia as New Marker for Metabolic Syndrome

Review of Hyperuricemia as New Marker for Metabolic Syndrome

Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese

Подагра, Кардиоваскулярные Риски И Сердечно-Сосудистые Заболевания: Кристаллическая Неразбериха

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