Uric acid excretion in rotavirus gastro-enteritis

Al-Shibli, Amar; Tatari, Hossam Al; Ameri, Abdulla Al; Ghatasheh, Ghassan; Issah, Mohamad; Attrach, Ibrahim Al; Narchi, Hassib

doi:10.1179/2046905513y.0000000077

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…Uric acid, creatinine, and BUN levels in serum and urine were determined as in our previous publication [13]. FEUA was calculated as follows: FEUA = (Uur × Scr)/(Sur × Ucr) × 100, expressed as a percentage [37].…”

Section: Determination Of Uric Acid Creatinine and Blood Urea Nitromentioning

confidence: 99%

Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3

Yuan

Chen

et al. 2015

Planta Med

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Emodinol, 1β,3β,23-trihydroxyolean-12-en-28-acid, as the main active ingredient firstly extracted from the rhizomes of Elaeagus pungens by our research group, has been demonstrated to exhibit uricosuric activity by our previous study. The aim of this study was to evaluate the uricosuric and nephroprotective effects of emodinol and explore its possible mechanisms in potassium oxonate-induced hyperuricemic mice with renal dysfunction. Mice were orally administrated 250 mg/kg of potassium oxonate once daily for 7 consecutive days to induce hyperuricemia with renal dysfunction. Emodinol was given at doses of 25, 50, and 100 mg/kg on the same day 1 h after oxonate treatment, and allopurinol (10 mg/kg) was given as a positive control. After 1 week, serum uric acid, serum creatinine, urine uric acid, urine creatinine, blood urea nitrogen, and hepatic xanthine oxidase activity were determined. The mRNA and protein levels of urate transporter 1, glucose transporter 9, ATP-binding cassette subfamily G member 2, organic anion transporter 1, oncoprotein-induced transcript 3, and organic cation/carnitine transporters in the kidney were detected by real-time polymerase chain reaction and Western blot analysis. In addition, urinary and renal Tamm-Horsfall glycoprotein concentrations were examined by ELISA assays. Emodinol significantly reduced serum urate levels, increased urinary urate levels and fractional excretion of uric acid, and inhibited hepatic xanthine oxidase activity in hyperuricemic mice. Moreover, potassium oxonate administration led to dys expressions of renal urate transporter 1, glucose transporter 9, ATP-binding cassette subfamily G member 2, organic anion transporter 1, and oncoprotein-induced transcript 3 as well as alternations of uromodulin concentrations, which could be reversed by emodinol. On the other hand, treatment of emodinol caused upregulated expressions of organic cation/carnitine transporters, resulting in an improvement of renal function characterized by decreased serum creatinine and blood urea nitrogen levels. Emodinol exhibited hypouricemic and nephroprotective actions by inhibiting xanthine oxidase activity and regulating renal ion transporters and oncoprotein-induced transcript 3, which may be a potential therapeutic agent in hyperuricemia and renal dysfunction.

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Section: Determination Of Uric Acid Creatinine and Blood Urea Nitromentioning

confidence: 99%

Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3

Yuan

Chen

et al. 2015

Planta Med

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“…Extensive research has identified Rotavirus as the most important viral cause of severe gastroenteritis in children worldwiden [15,16]. It has been reported [17]. The aim of this study was to evaluate the uric acid and creatinine parameters in patients with rotavirus gastroenteritis, one of the most common viral infections.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of some biochemical parameters of pediatric patients hospitalized for rotavirus in Şirnak Province: A retrospective review

Sonmez,

Tahiroglu,

Coskun

et al. 2023

Med-Science

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Rotavirus gastroenteritis is an important cause of worldwide morbidity and mortality in infants and children. The main cause of mortality is dehydration due to fluid loss and malnutrition. This study aims to examine the guiding parameters of uric acid and creatinine levels in the detection of dehydration and fluid deficit and inpatient management in cases of rotavirus gastroenteritis. Children who applied to Şirnak State Hospital, Pediatrics Polyclinics, children (6 months-18 years old) whose faecal samples were sent to the laboratory by the research pediatrician considering the diagnosis of rotavirus and whose microbiological examinations were confirmed by immunochromatographic methods (6 months-18 years old), were included in the study by scanning the system. When positive patients were evaluated, the mean age for serum uric acid was 1.06±1.53 and the mean age for serum creatinine was 1.10±1.37. The median value was 3.75 mg/dL in negative patients with serum uric acid levels, and 5.25 mg/dL in positive patients, which was statistically significant (p<0.01). The median value of serum creatinine level was 0.41 mg/dL in negative patients and 0.43 mg/dL in positive patients, which was statistically significant (p<0.05). With this study carried out in Şirnak province, we think that children in the region are severely affected by the rotavirus and face severe dehydration. Therefore, we think that all parameters affected by rotavirus should be evaluated according to regions and parents should be educated about the importance of rotavirus vaccine in the prevention of rotavirus gastroenteritis.

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“…We read with great interest the article entitled Uric acid excretion in rotavirus gastro-enteritis by Al-Shibli et al 1 and wish to comment on genetic predisposition to hyperuricaemia in children with rotavirus (RV) gastro-enteritis (GE). In 2005, a previously healthy 13-month-old boy was admitted with acute renal failure owing to bilateral obstruction of the pelvic ureteric junctions by uric acid stones associated with RV-GE.…”

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confidence: 99%

Genetic predisposition to hyperuricaemia in rotavirus gastro-enteritis

Kaneko¹,

Kimata²,

Tsuji³

2015

Paediatrics and International Child Health

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Uric acid excretion in rotavirus gastro-enteritis

Abstract: There was no significant difference in uric acid levels and uric acid excretion between patients with RV GE and those with other presumed viral causes of GE. Further studies with larger sample sizes including children with more severe dehydration and a prolonged course of GE are needed.

Cited by 4 publications

References 18 publications

Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3

Hypouricemic and Nephroprotective Effects of Emodinol in Oxonate-Induced Hyperuricemic Mice are Mediated by Organic Ion Transporters and OIT3

Evaluation of some biochemical parameters of pediatric patients hospitalized for rotavirus in Şirnak Province: A retrospective review

Genetic predisposition to hyperuricaemia in rotavirus gastro-enteritis

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