Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes Mellitus—The Effect on Adverse Pregnancy Outcomes

Pleskačová, Anna; Bartáková, Vendula; Chalásová, Katarína; Pácal, Lukáš; Kaňková, Kateřina; Tomandl, Josef

doi:10.3390/ijms19113696

Cited by 15 publications

(11 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More than 50% of patients with hyperuricemia have obesity, 40%-49.7% of patients with hyperuricemia have hypertension, and 9.5%-13.5% of patients with hyperuricemia also have diabetes [5]. Recently, it was reported that high urate and xanthine levels even became one of the risks of gestational diabetes mellitus [6]. However, the mechanism by which hyperuricemia develops into gout and its effect on other metabolic disorders is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout

Hong

Zheng

et al. 2020

IJMS

View full text Add to dashboard Cite

Hyperuricemia is a central risk factor for gout and increases the risk for other chronic diseases, including cardiometabolic disease, kidney disease, and hypertension. Overproduction of urate is one of the main reasons for hyperuricemia, and dietary factors including seafoods, meats, and drinking are contributed to the development of it. However, the lack of a suitable animal model for urate metabolism is one of the main reasons for the delay and limitations of hyperuricemia research. Combining evolutionary biological studies and clinical studies, we conclude that chicken is a preferred animal model for hyperuricemia. Thus, we provided chickens a high-protein diet (HPD) to evaluate the changes in the serum urate levels in chickens. In our study, the HPD increased the serum urate level and maintained it at a long-term high level in chickens. Long-term high serum urate levels induced an abnormal chicken claw morphology and the precipitation of monosodium urate (MSU) in joint synovial fluid. In addition, a long-term HPD also decreased the glomerular filtration rate and induced mild renal injury. Most importantly, allopurinol and probenecid displayed the positive effects in decreasing serum urate and then attenuated hyperuricemia in chicken model. These findings provide a novel model for hyperuricemia and a new opportunity to further investigate the effects of long-term hyperuricemia on other metabolic diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout

Hong

Zheng

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…In placenta, nobiletin down-regulated valine degradation associated proteins, while up-regulating xanthine and xanthosine salvage associated proteins. These findings are noteworthy, given the documented increased concentrations of valine [70] and xanthine [71] in GDM pregnancies. These data suggest that nobiletin may regulate placental nutrient metabolism in GDM mice.…”

Section: Discussionmentioning

confidence: 65%

Nobiletin exerts anti-diabetic and anti-inflammatory effects in anin vitrohuman model andin vivomurine model of gestational diabetes

et al. 2020

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is a global health issue, whereby pregnant women are afflicted with carbohydrate intolerance with first onset during pregnancy. GDM is characterized by maternal peripheral insulin resistance, thought to be driven by low-grade maternal inflammation. Nobiletin, a polymethoxylated flavonoid, possesses potent glucose-sensitizing and anti-inflammatory properties; however, its effects in GDM have not been assessed. The present study aimed to determine the effects of nobiletin on glucose metabolism and inflammation associated with GDM in both in vitro human tissues and an in vivo animal model of GDM. In vitro, treatment with nobiletin significantly improved TNF-impaired glucose uptake in human skeletal muscle, and suppressed mRNA expression and protein secretion of pro-inflammatory cytokines and chemokines in human placenta and visceral adipose tissue (VAT). Mechanistically, nobiletin significantly inhibited Akt and Erk activation in placenta, and NF-κB activation in VAT. In vivo, GDM mice treated with 50 mg/kg nobiletin daily via oral gavage from gestational day (gd) 1-17 or via i.p. injections from gd 10-17 significantly improved glucose tolerance. Pregnant GDM mice treated with nobiletin from either gd 1-17 or gd 10-17 exhibited significantly suppressed mRNA expression of pro-inflammatory cytokines and chemokines in placenta, VAT and subcutaneous adipose tissue (SAT). Using a quantitative mass spectrometry approach, we identified differentially abundant proteins associated with the effect of nobiletin in vivo. Together, these studies demonstrate that nobiletin improves glucose metabolism and reduces inflammation associated with GDM and may be a novel therapeutic for the prevention of GDM.

show abstract

“…Several purine degradation metabolites were upregulated in GDM up to the second trimester of pregnancy. Hypoxanthine was elevated in 2 prediagnosis studies [ 17 , 25 ] and in 1 unpublished postdiagnosis study (Heath, Phelan, La Frano; personal communication), xanthine was elevated in 2 prediagnosis studies [ 25 , 88 ] and in 1 at-diagnosis study [ 89 ], and uric acid increased between the first and second trimesters in a prediagnosis study [ 17 ]. Increased levels of xanthine in serum during early pregnancy may be predictive of GDM.…”

Section: Other Metabolic Pathways Alteredmentioning

confidence: 99%

Predictive Gestational Diabetes Biomarkers With Sustained Alterations Throughout Pregnancy

Heath

Luevano

Johnson

et al. 2022

Journal of the Endocrine Society

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) results in an increased risk of pre- and postpartum health complications for both the mother and child. Metabolomics analysis can potentially identify predictive biomarkers and provide insight into metabolic alterations associated with GDM pathogenesis and progression, but few metabolomics studies investigate alterations observed across the first and third trimester. We hypothesize that metabolites altered in first trimester GDM that remain altered in late pregnancy may best inform interventions. Metabolomic studies comparing plasma and serum metabolite alterations in GDM vs non-GDM pregnancies were retrieved by searching PubMed, Medline, and CINAHL Plus databases. The present scoping review summarizes the metabolites found to be consistently altered throughout the course of GDM and proposes mechanisms that explain how these metabolic perturbations relate to GDM development and progression. Metabolites involved in fatty acid metabolism, reductive carboxylation, branched chain amino acids metabolism, cell membrane lipid metabolism, purine degradation, and the gut microbiome were found to be altered throughout GDM pregnancies, with many of these pathways showing mechanistic links to insulin resistance, inflammation, and impaired cell signaling. Future studies are required to investigate if normalization of these perturbed pathways can be the targets of interventions.

show abstract

Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes Mellitus—The Effect on Adverse Pregnancy Outcomes

Cited by 15 publications

References 57 publications

High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout

High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout

Nobiletin exerts anti-diabetic and anti-inflammatory effects in anin vitrohuman model andin vivomurine model of gestational diabetes

Predictive Gestational Diabetes Biomarkers With Sustained Alterations Throughout Pregnancy

Contact Info

Product

Resources

About