Uric acid albumin ratio as a predictive marker of short-term mortality in patients with acute kidney injury

Özgür, Yasemin; Akın, Seydahmet; Yilmaz, Nuran; Gücün, Murat; Keskın, Onur

doi:10.15441/ceem.20.024

Cited by 14 publications

(18 citation statements)

References 21 publications

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“…has been proved to predict short-term mortality in individuals suffering from acute renal damage 12 . Furthermore, UAR predicted the severity of CAD better than the CRP-to-albumin ratio (CAR) in patients with non-ST-elevated myocardial infarction 11 .…”

Section: Discussionmentioning

confidence: 99%

“…It has also been linked to the extent of CAD in ACS patients 11 . Furthermore, UAR has been shown to be a strong predictor of short-term mortality in patients with acute renal failure 12 . To the best of our knowledge, in the literature, there is a lack of studies supporting the association between UAR and the development of NOAF in STEMI patients treated with primary percutaneous coronary intervention (pPCI).…”

Section: Introductionmentioning

confidence: 99%

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Predictive value of uric acid/albumin ratio for the prediction of new-onset atrial fibrillation in patients with ST-Elevation myocardial infarction

2022

RIC

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Background: There is a lack of studies supporting the association between the uric acid/albumin ratio (UAR) and the development of new-onset atrial fibrillation (NOAF) in ST-elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (pPCI). Objective: The objective of the study was to assess the efficacy of the UAR for predicting the occurrence of NOAF in STEMI patients undergoing pPCI. Methods: We recruited 1484 consecutive STEMI patients in this retrospective and cross-sectional investigation. The population sample was classified based on the development of NOAF during hospitalization. NOAF was defined as an atrial fibrillation (AF) observed during hospitalization in patients without a history of AF or atrial flutter. The UAR was computed by dividing the serum uric acid (UA) level by serum albumin level.Results: After pPCI, 119 STEMI patients (8%) were diagnosed with NOAF. NOAF patients had higher serum UAR levels than individuals who did not have NOAF. According to the multivariable logistic regression model, the UAR was an independent predictor for NOAF in STEMI patients (OR: 6.951, 95% CI: 2.978-16.28, p < 0.001). The area under curve (AUC) value of the UAR in a receiver operating characteristics (ROC) evaluation was 0.758, which was greater than those of its components (albumin [AUC: 0.633] and UA [AUC: 0.647]) and C-reactive protein (AUC: 0.714). The optimal UAR value in predicting NOAF in STEMI patients was greater than 1.39, with a sensitivity of 69% and a specificity of 74.5%. Conclusion: To the best of our knowledge, this is the first study indicating that the UAR was an independent predictor of NOAF development in STEMI patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predictive value of uric acid/albumin ratio for the prediction of new-onset atrial fibrillation in patients with ST-Elevation myocardial infarction

2022

RIC

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“…As a new predictive index, the prognostic value of the sUAR has been investigated in patients with STEMI, non-ST segment elevation myocardial infarction, and AKI for predicting mortality. 16 , 30 , 31 Yeter et al found that a sUAR > 1.7 was significantly associated with AKI in critically ill patients. 15 Recently, Faysal et al also demonstrated that sUAR (>1.62) had a greater predictive value for contrast-induced nephropathy, and was superior to serum uric acid and albumin.…”

Section: Discussionmentioning

confidence: 99%

“… 14 The serum uric acid/albumin ratio (sUAR), which is derived from serum uric acid and serum albumin, has been reported as a novel inflammatory marker in predicting AKI, and is associated with mortality in patients with AKI. 15 , 16 Recently, Faysal et al conducted a retrospective study and found that sUAR was an independent predictor of contrast-induced nephropathy. 17 However, the sample size was relatively small and the definition of contrast-induced nephropathy was proved to be not often use in patients with STEMI.…”

Section: Introductionmentioning

confidence: 99%

Elevated Serum Uric Acid/Albumin Ratio as a Predictor of Post-Contrast Acute Kidney Injury After Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction

Zhang¹,

Xu²,

He³

et al. 2022

JIR

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Background The serum uric acid/albumin ratio (sUAR), a novel inflammatory marker, effectively predicts acute kidney injury (AKI) and cardiovascular outcomes. However, whether the sUAR predicts post-contrast acute kidney injury (PC-AKI) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) remains uncertain. In this study, we evaluated the association between the sUAR and PC-AKI in patients with STEMI undergoing PCI. Methods We consecutively recruited patients with STEMI who underwent PCI and stratified them into three groups according to the terciles of the sUAR. The primary outcome was the incidence of PC-AKI. The association between the sUAR and PC-AKI was assessed by multivariate logistic regression analysis. Results A total of 2861 patients with STEMI were included in this study. The incidence of PC-AKI increased stepwise with increasing sUAR tercile (2.6% vs 4.0% vs 11.6%, p < 0.001), and the incidence of in-hospital major adverse clinical events (MACEs) was highest among patients in the Q3 group. Multivariate logistic regression analysis revealed that the sUAR was also an independent predictor of PC-AKI (continuous sUAR, per 1-unit increase, odds ratio [OR] [95% confidence interval (CI)]: 1.06 [1.02–1.10], p = 0.005; tercile of sUAR, OR [95% CI] for Q2 and Q3: 1.18 [0.69–2.01] and 1.85 [1.12–3.06], respectively, with Q1 as a reference) but not in-hospital MACEs. In the receiver operating characteristic (ROC) analysis, the area under the curve (AUC) of the sUAR for predicting PC-AKI was 0.708 (95% CI: 0.666–0.751), and ROC analysis also showed that the sUAR was superior to uric acid and albumin alone in predicting PC-AKI. Conclusion Increasing sUAR was significantly associated with a higher risk of PC-AKI but not in-hospital MACEs in patients with STEMI who underwent PCI, suggesting that sUAR had a predictive value for PC-AKI after PCI in patients with STEMI. Further studies are required to confirm this finding.

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“…17 Similarly, Ozgur et al reported that UAR was associated with short-term mortality in patients with AKI. 18 Cakmak et al noted that UAR was related to the extent of coronary artery disease and predicted clinical outcomes better than the C-reactive protein to albumin ratio and fibrinogen to albumin ratio in non–ST-elevated myocardial infarction patients. 19…”

Section: Introductionmentioning

confidence: 99%

Serum Uric Acid to Albumin Ratio Can Predict Contrast-Induced Nephropathy in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

Şaylık¹,

Çınar²,

Akbulut³

et al. 2022

Angiology

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Contrast-induced nephropathy (CIN) is one of the common complication of ST-elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (pPCI). Serum uric acid to albumin ratio (UAR) is a novel marker, which is associated with acute kidney injury in intensive care unit patients. We investigated the predictive value of UAR for the development of CIN in STEMI patients (n = 1379) after pPCI. The diagnosis of CIN was made based on an increase of basal creatinine levels >.5 mg/dL or 25% within 72 h after pPCI; 128 patients were in the CIN (+) group and 1251 patients were in the CIN (−) group. CIN (+) patients had higher serum uric acid (SUA), UAR, and lower albumin levels than CIN (−) patients. Age, diabetes, hypertension, hemoglobin, glucose at admission, basal creatinine, peak troponin I, total bilirubin, contrast volume/glomerular filtration rate, and UAR were independent predictors of CIN. A cutoff value of 1.62 for UAR detected CIN development with a sensitivity of 54% and specificity of 87.4%, and the discrimination ability of UAR was better than that of SUA or albumin. In conclusion, UAR was an independent predictor of the development of CIN.

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Uric acid albumin ratio as a predictive marker of short-term mortality in patients with acute kidney injury

Cited by 14 publications

References 21 publications

Predictive value of uric acid/albumin ratio for the prediction of new-onset atrial fibrillation in patients with ST-Elevation myocardial infarction

Predictive value of uric acid/albumin ratio for the prediction of new-onset atrial fibrillation in patients with ST-Elevation myocardial infarction

Elevated Serum Uric Acid/Albumin Ratio as a Predictor of Post-Contrast Acute Kidney Injury After Percutaneous Coronary Intervention in Patients with ST-Segment Elevation Myocardial Infarction

Serum Uric Acid to Albumin Ratio Can Predict Contrast-Induced Nephropathy in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention

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