Urethral Stricture Following Antiandrogen Therapy

Yokoyama, Masao; Fukutani, Keiko; Kawamura, Takeshi; Shoji, Fumio; Ohtani, Mikinobu

doi:10.1016/s0022-5347(17)53775-1

Cited by 2 publications

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“…Recently we described a high incidence of urethral stricture following antiandrogen therapy for cancer of the prostate [3]. This type of stricture differs from other types of urethral strictures in several points.…”

Section: Discussionmentioning

confidence: 93%

“…Although estrogens were suspected to be a causative agent, the previous communication [3] did not draw a conclusion due to the limited number of patients who had undergone castration alone. The present study disclosed that all of the 24 patients with urethral strictures had been treated with estrogens with or without castration and that no stricture was found in those patients who had under gone castration alone as well as in all patients without any antiandrogen therapy.…”

Section: Discussionmentioning

confidence: 95%

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Stricture of the Anterior Urethra following Estrogen Therapy in Patients with Prostatic Cancer

Yokoyama¹,

Fukutani²,

Kawamura³

et al. 1983

Urol Int

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A high incidence of urethral strictures was noted in patients with prostatic cancer who were treated by antiandrogen therapy. Retrograde urethrograms showed urethral stricture in 24 of 42 patients (57%) after or during the therapy, despite the fact that no stricture was found before initiation of therapy. The stricture was long and the entire penile urethra was narrowed, associated with more severely constricted portions. All of the patients with urethral stricture had received estrogens, while none of the patients who had undergone castration alone or had not received any therapy showed a stricture. The strictures disappeared after the cessation of estrogen administration. These results indicate that estrogen administration induces stricture in the male anterior urethra. It is suggested that large amounts of estrogen cause atrophy and fibrosis of the spongy and cavernous bodies of the penis, depriving the urethra of its normal elasticity, which results in urethral stricture. This stricture is one of the complications of estrogen therapy for cancer of the prostate.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Stricture of the Anterior Urethra following Estrogen Therapy in Patients with Prostatic Cancer

Yokoyama¹,

Fukutani²,

Kawamura³

et al. 1983

Urol Int

Self Cite

View full text Add to dashboard Cite

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Urinary Retention Induced by Estrogen Injections in Mice: An Analytical Model

et al. 1985

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Daily subcutaneous injections of pharmacological doses of 17 beta-estradiol (E2, 0.4 micrograms./gm. body weight) resulted in significant urinary retention in the bladder of castrated mice. Although the urinary retention developed in both male and female mice, the increase in urethral resistance to urinary flow and the dilatation of posterior urethra were observed only in castrated male mice receiving E2. Histological changes common to male and female mice were cornification and stratification of urethral epithelium and fibrosis of connective tissues surrounding the urethra, suggesting that these changes may cause the urinary retention. Although the exact mechanism has not been defined, the urinary retention produced by the present method may be useful as a model of human disease.

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Urethral Stricture Following Antiandrogen Therapy

Cited by 2 publications

References 0 publications

Stricture of the Anterior Urethra following Estrogen Therapy in Patients with Prostatic Cancer

Stricture of the Anterior Urethra following Estrogen Therapy in Patients with Prostatic Cancer

Urinary Retention Induced by Estrogen Injections in Mice: An Analytical Model

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