Urinary Retention Induced by Estrogen Injections in Mice: An Analytical Model

Abstract

Daily subcutaneous injections of pharmacological doses of 17 beta-estradiol (E2, 0.4 micrograms./gm. body weight) resulted in significant urinary retention in the bladder of castrated mice. Although the urinary retention developed in both male and female mice, the increase in urethral resistance to urinary flow and the dilatation of posterior urethra were observed only in castrated male mice receiving E2. Histological changes common to male and female mice were cornification and stratification of urethral epithelium and fibrosis of connective tissues surrounding the urethra, suggesting that these changes may cause the urinary retention. Although the exact mechanism has not been defined, the urinary retention produced by the present method may be useful as a model of human disease.

Hydronephrosis and Urine Retention in Estrogen-Implanted Athymic Nude Mice

“…In both male and female gonadectomized DS (mutation disorganization) strain mice exposed to 17b-estradiol, significant urine retention and 100% hydronephrosis were observed. 7 An additional study found that 17b-estradiol treatment administered via subcutaneous pellets caused hydronephrosis and urine retention in female C57BL/6J mice. 8 The results observed in lab animals seem to be contradictory to the studies conducted in humans, possibly because of a different dose regimen of estrogen in lab animals and because postmenopausal women are deprived of estrogen for a very long time, which could trigger many pathways.…”

Effects of varying doses of estrogen and caudal pressure on wheel running in orchidectomized male mice

“…This interaction has been noted to induce significant bladder distention in mice (Kuroda et al. ). As such, the close anatomical proximity of the urinary bladder to the hind limbs could speculatively alter the mechanics of running during estrogen treatment, and therefore, satisfactorily explain the lackluster recovery observed during short‐term estrogen treatment and manipulation.…”

“…The retention of urine as a byproduct of estrogen treatment is well established in the scientific literature (Kuroda et al. ; Kuiper et al. ; Levin‐Allerhand et al.…”

Fowler's syndrome—progesterone deficiency or oestrogen excess?

“…3 Although not reviewed by Osman and Chapple, 1 evidence suggests that oestrogens could increase detrusor and u rethral p ressure and cause urinary retention. [4][5][6][7] Kuroda et al 4 reported that oestradiol injections resulted in urinary retention CORRESPONDENCE Fowler's syndrome-progesterone deficiency or oestrogen excess? Jae I. Shin in the bladders of castrated mice, and Bump and Friedman 5 showed that oestradiol replacement in hypo-oestrogenic baboons increased functional urethral length and mean urethral pressure.…”