Urethral Reconstruction Using Bone Marrow Mesenchymal Stem Cell– and Smooth Muscle Cell–Seeded Bladder Acellular Matrix

Li, C.L.; Liao, Wenbiao; Yang, Sixing; Song, Chao; Li, Y.W.; Xiong, Yunhe; Chen, L.

doi:10.1016/j.transproceed.2013.07.055

Cited by 32 publications

(23 citation statements)

References 22 publications

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“…To date, many attempts have been made to determine appropriate substitutes for urethral reconstruction, and in general, it is believed that seeding cells is necessary for constructing an artificial biomaterial scaffold that is suitable for reconstruction of extensive urethral defects. Various types of cells have been adopted in animal and clinical experiments, such as bone marrow mesenchymal stem cells [19][20][21], urethral epithelial cells [22] and smooth muscle cells [6,7,[23][24][25], urine-derived stem cells [26], mesothelial cells [27], adipose-derived stem Cells [28,29], and oral keratinocytes [30], and other cell types.…”

Section: Discussionmentioning

confidence: 99%

Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model

Jia

Tang

et al. 2015

Biomaterials

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Section: Discussionmentioning

confidence: 99%

Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model

Jia

Tang

et al. 2015

Biomaterials

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“…At 8 and 16 weeks, there was presence of multilayer urothelium, signs of neovascularization, and organized smooth muscle bundles within the graft [11]. These preliminary results show that BMSC can be constructed into tissueengineered sheet grafts that can further differentiate into organized multilayered urothelial tissue with the potential of longterm graft survival (signs of neovascularization).…”

Section: Urethramentioning

confidence: 66%

Bone Marrow Mesenchymal Stem Cell Therapy for Voiding Dysfunction

Campeau

2015

Curr Urol Rep

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Lower urinary tract symptoms can significantly impact quality of life. Current standard treatments are not always effective and are associated with complications and side effects. The discovery of stem cells led to research into cell-based therapies for treatment of disorders of voiding dysfunction. Bone marrow mesenchymal stem cells are particularly promising given their ability to differentiate into a variety of cell types. Recent studies have investigated bone marrow stem cells to treat a number of functional voiding pathologies including bladder outlet obstruction, neurogenic bladder, and stress urinary incontinence. Experiments in tissue regeneration have also attempted to create artificial bladders and urethras. The purpose of this article is to critically review the literature regarding the use of bone marrow mesenchymal stem cells in treatment of voiding dysfunction.

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“…Biological scaffolds such as bladder acellular matrix (BAM),23–27 small intestinal submucosa (SIS),28,29 acellular amniotic membrane,30 and acellular corpus spongiosum (ACSM)31 have been previously experimented primarily because they mimic the native extracellular matrix (ECM). However, research is still ongoing to optimize their use for urological reconstruction 32.…”

Section: Biomaterials For Urothelium Regenerationmentioning

confidence: 99%

Biofabrication and biomaterials for urinary tract reconstruction

Elsawy

Mel

2017

RRU

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Reconstructive urologists are constantly facing diverse and complex pathologies that require structural and functional restoration of urinary organs. There is always a demand for a biocompatible material to repair or substitute the urinary tract instead of using patient’s autologous tissues with its associated morbidity. Biomimetic approaches are tissue-engineering tactics aiming to tailor the material physical and biological properties to behave physiologically similar to the urinary system. This review highlights the different strategies to mimic urinary tissues including modifications in structure, surface chemistry, and cellular response of a range of biological and synthetic materials. The article also outlines the measures to minimize infectious complications, which might lead to graft failure. Relevant experimental and preclinical studies are discussed, as well as promising biomimetic approaches such as three-dimensional bioprinting.

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Urethral Reconstruction Using Bone Marrow Mesenchymal Stem Cell– and Smooth Muscle Cell–Seeded Bladder Acellular Matrix

Cited by 32 publications

References 22 publications

Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model

Urethral tissue regeneration using collagen scaffold modified with collagen binding VEGF in a beagle model

Bone Marrow Mesenchymal Stem Cell Therapy for Voiding Dysfunction

Biofabrication and biomaterials for urinary tract reconstruction

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