Ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation: a case report

Ren, Shuang; Feng, Hualin; Bao, Yige; Yi, Wei; Ou, Yong; Wang, Yaoqian; Liu, Qian; Zhong, Shan; Zhou, Fang; Fan, Shida; Wang, Qiang; Luo, Cheng; Zhengjun, Chen; Nie, Yu; Wang, Dong

doi:10.1186/s12893-021-01099-1

Cited by 7 publications

(6 citation statements)

References 22 publications

(9 reference statements)

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“…However, sarcomatoid UC is resistant to conventional chemotherapy, and a standard treatment protocol for sarcomatoid UC of the upper urinary tract has not yet been established because of the limited number of cases. To the best of our knowledge, only one case of sarcomatoid UC of the upper urinary tract treated with immunotherapy has been reported to date, and no effectiveness has been confirmed [34]. The patient in our case is the first reported case of sarcomatoid UC of the renal pelvis partially responded to immunotherapy, supporting the prospects of immunotherapy as a promising treatment for this disease.…”

Section: Discussionmentioning

confidence: 55%

Sarcomatoid urothelial carcinoma of the renal pelvis treated with immunotherapy

et al. 2023

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Background Sarcomatoid carcinoma is a rare, high-grade malignancy with epithelial and mesenchymal components. It may be a good candidate for immunotherapy because it is associated with overexpression of programmed cell death ligand 1. Sarcomatoid urothelial carcinoma (UC) of the upper urinary tract is extremely rare. Here we report the first case of sarcomatoid UC of the renal pelvis that responded to immunotherapy. Case presentation A 79-year-old man was referred to our hospital complaining of various symptoms, including anorexia and abdominal pain. A computed tomography scan revealed a right atrial tumor, a 9 cm left renal mass with a renal vein tumor thrombus, para-aortic lymphadenopathy, and multiple small lung nodules. The patient underwent resection of the right atrial tumor. Pathological analysis of the tumor did not lead to an accurate diagnosis even after several rounds of immunohistochemistry. He underwent a needle biopsy of the left kidney and was initially diagnosed with collecting duct carcinoma, a rare subtype of renal cell carcinoma (RCC). Following the initial diagnosis, immunotherapy with nivolumab and ipilimumab commenced. Thereafter, almost all lesions, including the left renal tumor, were reduced in size. However, he underwent a left nephrectomy approximately a year after beginning immunotherapy due to repeated left renal bleeding. Histological examination of the nephrectomy specimen revealed two forms of cancer—sarcomatoid UC and conventional high-grade UC. Two months after surgery, the patient was found to have new lung metastases. He underwent chemotherapy with gemcitabine and cisplatin, followed by immunotherapy with pembrolizumab. However, both treatments were ineffective. The patient died of cancer 19 months after his first admission. Conclusions The presented case of sarcomatoid UC of the renal pelvis that partially responded to immunotherapy suggests that immunotherapy can be a promising treatment for sarcomatoid UC.

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Section: Discussionmentioning

confidence: 55%

Sarcomatoid urothelial carcinoma of the renal pelvis treated with immunotherapy

et al. 2023

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“…According to certain research, patients with higher pT stages may be more likely to benefit from this and get better results from lymph node dissection when using a conventional anatomical template [8]. Ren et al [9] stated that neoadjuvant chemotherapy (NAC) before RNU was shown to produce absolute increases in overall survival by 11%, tumor-specific survival by 18%, and progression-free survival by 13%. This was similarly observed in patients treated with cisplatin-based adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Complete Response of Rare Sarcomatoid Upper Tract Urothelial Carcinoma Variant: Case Report and Literature Review

Warli¹,

Laksmi²,

Lubis³

et al. 2023

Case Rep Oncol

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Infiltrating urothelial carcinoma sarcomatoid variant is a rare variant of urothelial carcinoma. We report a case of a 68-year-old female with a history of hematuria. CT scan with contrast showed a mass in the 1/3 distal of the right ureter. The biopsy result showed a high-grade infiltrating urothelial carcinoma. A radical nephroureterectomy was performed but at the follow-up after 3 months, there was a recurrent mass and gemcitabine-cisplatin chemotherapy was given. Since a high-grade infiltrating urothelial carcinoma sarcomatoid variant was an aggressive tumor, we need to give more attention to evaluating this tumor.

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“…However, its concurrent association with chondrosarcoma is infrequent. Except for a single case report of high-grade urothelial carcinoma of the right ureter with squamous cell carcinoma and sarcomatoid carcinoma differentiation, no literature is available where both variants exist simultaneously in a case of sarcomatoid urothelial carcinoma [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid Urothelial Carcinoma of the Urinary Bladder With Chondrosarcomatous and Concurrent Divergent Squamous Cell Carcinoma Differentiation– A Rare Entity

Pal¹,

Srinivas²,

Kalra³

et al. 2022

Cureus

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We present an extremely rare case where the sarcomatoid urothelial carcinoma of the urinary bladder was present with chondrosarcomatous and squamous cell differentiation.A 74-year-old male smoker presented with intermittent hematuria with the passage of clots. On imaging, an irregular polypoidal lesion was diagnosed near the right vesicoureteric junction, and transurethral resection of the bladder tumor was performed. Histopathological examination showed sarcomatoid urothelial carcinoma with chondrosarcoma and squamous cell differentiation. He refused the surgical treatment of radical cystectomy and underwent Gemcitabine and Cisplatin chemotherapy. He died nine months after the diagnosis. Sarcomatoid urothelial carcinoma is a high-grade biphasic neoplasm with malignant epithelial and mesenchymal components. Its association with squamous cell carcinoma is infrequent. It is very aggressive, and there is no standard treatment for this disease. The radical surgical option appears to be the main form of treatment. It is scarce with a grave prognosis.

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Ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation: a case report

Cited by 7 publications

References 22 publications

Sarcomatoid urothelial carcinoma of the renal pelvis treated with immunotherapy

Sarcomatoid urothelial carcinoma of the renal pelvis treated with immunotherapy

Complete Response of Rare Sarcomatoid Upper Tract Urothelial Carcinoma Variant: Case Report and Literature Review

Sarcomatoid Urothelial Carcinoma of the Urinary Bladder With Chondrosarcomatous and Concurrent Divergent Squamous Cell Carcinoma Differentiation– A Rare Entity

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