Ureteral Segmental Replacement Using Multilayer Porcine Small-Intestinal Submucosa

Abstract

Technically, Surgisis ES was easily modeled, providing conditions for a water-tight anastomosis. None of the animals developed urinary fistula. Regeneration of urothelium and muscle were induced and supported by the graft. However, functional replacement was not successful. A suitable material for this purpose has yet to be discovered.

Utilização da submucosa de intestino delgado porcino como retalho para aumento da capacidade vesical em cães

“…A angiogênese é fundamental para o suprimento vascular do tecido vesical em remodelação. Proliferação e migração de células endoteliais, induzidos por fatores quimiotáxicos presentes na matriz extracelular e nas células adjacentes, promovem a neoangiogênese [13][14][15][16][17][18][19][20][21][22][23] . São essas células endoteliais que vão originar os tubos vasculares, ramos e capilares propriamente ditos.…”

Rabbit Ear Cartilage Regeneration With a Small Intestinal Submucosa Graft

“…36,37 Mantovani et al 38 have recently reported the first successful series of urethral stricture repairs in humans employing SIS grafts, and O'Connor et al 39 have successfully employed SIS patch grafts as a means of reinforcing parenchymal and collecting system defects in 24 partial nephrectomies. Patch defects in the canine esophagus repaired with SIS have shown replacement of the graft material with organized collagenous connective tissue, an intact squamous epithelium, and appropriately oriented skeletal muscle, 40 and successful use of SIS as a 41 However, stenosis has occurred when SIS has been used as a tube graft to repair circumferential defects in the pig ureter 42 and in the canine ureter, 43 small intestine, 41,44 and esophagus. 40 The difference between successful application of vascular SIS tube grafts and their failed application in these locations has been the absence of intraluminal pressure with resultant collapse and stenosis despite appropriate tissue regeneration.…”

Traumatic rectourethral fistula repair: A potential application of porcine small intestinal submucosa

“…It acts as a scaffold for the surrounding tissue to grow, supports vessel growth, and fosters cellular differentiation and gets completely incorporated in it. [4] Surgisis ® is being used for various purposes in urology; urethral reconstruction,[5] ureteric reconstruction,[6] urethral diverticular surgery,[7] bladder neck fistula closure after exstrophy repair,[8] surgery for peyronie's disease, penile prosthetic surgery,[9] and nephron sparing surgery. [10] Surgisis ® is available in various sizes and for RUF closure, a 7 cm × 4 cm size fistula repair product (G13181) (http://www.cookmedical.com/sur/dataSheet.do?id = 5643) was used.…”