Rabbit Ear Cartilage Regeneration With a Small Intestinal Submucosa Graft

Abstract

The results of the study using porcine small intestinal submucosa as a bioscaffold for cartilage regeneration are promising and justify further animal and human studies.

Tissue engineering and cartilage regeneration for auricular reconstruction

“…In the study by Pribitkin et al this material have been interposed following excision of rabbit auricular cartilage, showing that some sort of cartilage regeneration was only possible in presence of adjacent host cartilage or perichondrium. These results justify further animal and then human studies [36].…”

Acellular porcine intestinal submucosa as fascial graft in an animal model: Applications for revision tympanoplasty

“…Histologically, these grafts often are indistinguishable from native tissue. Pribitkin et al 19 demonstrated complete replacement of Surgisis graft material at three months postoperatively by using a rabbit ear cartilage model. Pribitkin et al's microscopic findings concur with the findings of this study, including the early inflammatory infiltration containing eosinophils, multinucleated giant cells and lymphocytes.…”

Clinical outcome of exclusive endoscopic tympanoplasty with porcine small intestine submucosa in 72 patients

“…Spiegel and Kessler performed tympanoplasties with SIS in five chinchillas and found that all remained healed at 6 weeks postoperatively 21 . Pribitkin et al 22 confirmed that SIS was infiltrated with inflammatory cells and was substituted by recipient tissue bioscaffold. They reported that SIS graft was completely replaced by cartilage at 3 months postoperatively in a rabbit ear model.…”