Tissue engineering and cartilage regeneration for auricular reconstruction

Ciorba, Andrea; Martini, Alessandro

doi:10.1016/j.ijporl.2006.03.013

Cited by 64 publications

(56 citation statements)

References 41 publications

(39 reference statements)

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“…There is a lot of literature on this topic. [26][27][28][29][30][31][32][33][34][35][36][37] Extra-articular cartilage is usually repaired by the means of proliferation and chondrogenic differentiation of the perichondrial cells. The defects of hyaline cartilage and the extensive defects of costal and auricular cartilages are usually filled up with fibrous connective tissue or fibrous cartilage, which both do not have adequate functional properties; that determines persistent attempts to find new possibilities for cartilage regeneration.…”

Section: Cartilage As a Subject Of Regenerationmentioning

confidence: 99%

Laser-induced regeneration of cartilage

et al. 2011

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Abstract. Laser radiation provides a means to control the fields of temperature and thermo mechanical stress, mass transfer, and modification of fine structure of the cartilage matrix. The aim of this outlook paper is to review physical and biological aspects of laser-induced regeneration of cartilage and to discuss the possibilities and prospects of its clinical applications. The problems and the pathways of tissue regeneration, the types and features of cartilage will be introduced first. Then we will review various actual and prospective approaches for cartilage repair; consider possible mechanisms of laser-induced regeneration. Finally, we present the results in laser regeneration of joints and spine disks cartilages and discuss some future applications of lasers in regenerative medicine. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Cartilage As a Subject Of Regenerationmentioning

confidence: 99%

Laser-induced regeneration of cartilage

et al. 2011

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“…Cartilage lacks an intrinsic regeneration capacity, 48 which makes cartilage reconstruction challenging. Cartilage reconstruction has become a major focus of tissue engineering research.…”

Section: Discussionmentioning

confidence: 99%

Marine Collagen Scaffolds for Nasal Cartilage Repair: Prevention of Nasal Septal Perforations in a New Orthotopic Rat Model Using Tissue Engineering Techniques

Bermueller

Schwarz

Elsaesser

et al. 2013

Tissue Engineering Part A

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Autologous grafts are frequently needed for nasal septum reconstruction. Because they are only available in limited amounts, there is a need for new cartilage replacement strategies. Tissue engineering based on the use of autologous chondrocytes and resorbable matrices might be a suitable option. So far, an optimal material for nasal septum reconstruction has not been identified. The aim of our study was to provide the first evaluation of marine collagen for use in nasal cartilage repair. First, we studied the suitability of marine collagen as a cartilage replacement matrix in the context of in vitro three dimensional cultures by analyzing cell migration, cytotoxicity, and extracellular matrix formation using human and rat nasal septal chondrocytes. Second, we worked toward developing a suitable orthotopic animal model for nasal septum repair, while simultaneously evaluating the biocompatibility of marine collagen. Seeded and unseeded scaffolds were transplanted into nasal septum defects in an orthotopic rat model for 1, 4, and 12 weeks. Explanted scaffolds were histologically and immunohistochemically evaluated. Scaffolds did not induce any cytotoxic reactions in vitro. Chondrocytes were able to adhere to marine collagen and produce cartilaginous matrix proteins, such as collagen type II. Treating septal cartilage defects in vivo with seeded and unseeded scaffolds led to a significant reduction in the number of nasal septum perforations compared to no replacement. In summary, we demonstrated that marine collagen matrices provide excellent properties for cartilage tissue engineering. Marine collagen scaffolds are able to prevent septal perforations in an autologous, orthotopic rat model. This newly described experimental surgical procedure is a suitable way to evaluate new scaffold materials for their applicability in the context of nasal cartilage repair.

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“…The reasons are complex and especially related to the unsolved problems of scaffold design and of the differentiation induction of stem cells to produce elastic ear cartilage [161] . There are numerous other less -attended fi elds of research in head and neck surgery needing stem cell technology, for example, the mucosal reconstruction in the upper ADT.…”

Section: Application Of Stem Cells In Regenerative Medicinementioning

confidence: 99%