Uremic Pruritus – An Update

Urbonas, Arunas; Schwartz, Robert A.; Szepietowski, Jacek C.

doi:10.1159/000046272

Cited by 72 publications

(80 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are not novel as it was demonstrated that the risk of UP increased in patients with severely elevated serum calcium and phosphorus levels and calcium-phosphorus product. 4,30,[35][36][37][38][39] Lastly, the relationship between depression and UP is not a novel finding as well, being reported previously in other studies. 39,40 In conclusion, the two parameters related to mortality in HD patients, namely pruritus and HbA1c, are independently related with each other.…”

Section: Discussionsupporting

confidence: 68%

HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Afsar

Afşar

2011

Renal Failure

View full text Add to dashboard Cite

Objective: Uremic pruritus (UP) remains a frequent problem in hemodialysis (HD) patients and is related to mortality. Poor glycemic control, as evaluated by hemoglobin A1c (HbA1c), is also associated with morbidity and mortality in HD patients. In this study, we investigated the relationship between UP and HbA1c in HD patients. Methods: Sociodemographic, clinical, and laboratory variables, depressive symptoms, and health-related quality of life were assessed. Severity of UP was evaluated by visual analogue scale (VAS). The scale consisted of a 10 cm horizontal line marked from 0 (denoting no itch) to 10 (denoting worst possible imaginable itch). Results: Totally, 75 patients (male/female, 41/34; diabetic/nondiabetic, 29/46; age, 51.9 ± 13.5 years) were included. The VAS pruritus score was higher in diabetic patients compared with nondiabetic patients (4.7 ± 2.8 vs. 3.0 ± 1.0, p : 0.015). In diabetics, VAS pruritus score was independently related with calcium-phosphorus product (b : +0.637, p < 0

show abstract

Section: Discussionsupporting

confidence: 68%

HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Afsar

Afşar

2011

Renal Failure

View full text Add to dashboard Cite

show abstract

“…Uraemic pruritus (UP), i.e. a chronic condition caused by renal failure has a prevalence ranging from 20% to 70% [8][9][10][11][12][13]. Not yet fully understood, UP usually starts 3 to 6 months after the onset of renal dialysis [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Impact of Uraemic Pruritus on Quality of Life among End Stage Renal Disease Patients on Dialysis

Ibrahim

Elshahid

Baz

et al. 2016

JCDR

View full text Add to dashboard Cite

“…Dry skin (xerosis) is the most frequent cutaneous manifestation of ESRD and has been suggested as a cause of uraemic pruritus [9][10][11][12][13]. Although a positive correlation between the severity of clinical dry skin and pruritus has been shown [11,14], others have failed to find a relationship between either trans-epidermal water loss (TEWL, a measure of the rate of water loss through the skin) or skin hydration and pruritus [15,16].…”

Section: Introductionmentioning

confidence: 99%

Skin barrier structure and function and their relationship to pruritus in end-stage renal disease

Yosipovitch

Duque

Patel

et al. 2007

Nephrology Dialysis Transplantation

View full text Add to dashboard Cite

Background. The relationship between dry skin and uraemic pruritus remains controversial. In addition, there is a lack of published data describing the structure and function of the stratum corneum (SC) in end-stage renal disease (ESRD). The purpose of the present study was to assess the function and structure of the skin barrier in patients with ESRD and to correlate any abnormalities with uraemic pruritus. Methods. Thirty-eight subjects participated in the study; 20 with ESRD and 18 healthy controls. Subjects underwent evaluation of SC integrity and permeability barrier recovery, SC surface pH, pruritus and dry skin. The content of glycerol, an important endogenous humectant, was assessed in D-squame tape strips from seven patients with ESRD. Skin biopsies from six of these patients were examined by electron microscopy using ruthenium tetroxide (Ru0 4 )-post-fixation. Results. Although SC integrity was impaired in ESRD patients (P ¼ 0.001), there were no significant differences in permeability barrier recovery rates between ESRD subjects and controls. However, there was a high significant negative correlation between SC glycerol content and dry skin in the arms of ESRD subjects (r ¼ À0.866, P ¼ 0.01). Yet, there was no consistent correlation between pruritus and either dry skin, SC integrity, glycerol content or surface pH. Electron microscopy revealed no significant ultrastructural abnormalities, with particular reference to the lipid bi-layer.Conclusions. SC integrity, but not permeability barrier recovery, is impaired in dialysis patients. Although dry skin in ESRD is associated with reduced SC glycerol levels, the ultra-structure appears to be unaffected.

show abstract

Uremic Pruritus – An Update

Cited by 72 publications

References 68 publications

HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Impact of Uraemic Pruritus on Quality of Life among End Stage Renal Disease Patients on Dialysis

Skin barrier structure and function and their relationship to pruritus in end-stage renal disease

Contact Info

Product

Resources

About