HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Afsar, Barış; Afşar, Rengin Elsürer

doi:10.3109/0886022x.2011.560401

Cited by 18 publications

(24 citation statements)

References 39 publications

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“…According to the other reports, pruritus may be independently associated with higher calcium [18,20,35], phosphorus, and iPTH concentrations [40]. We showed that higher Ca × P product significantly increased the risk of itching on dialysis (Table 5).…”

Section: Discussionsupporting

confidence: 64%

Substance P and intensity of pruritus in hemodialysis and peritoneal dialysis patients

et al. 2013

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BackgroundUremic pruritus is a common complication in patients undergoing dialysis. The pathophysiological mechanisms of pruritus in patients with end-stage renal disease remain unknown. Neuropeptides, including substance P, are postulated to play an important role in the pathogenesis of pruritus. The aim of this study was to evaluate the role of substance P in uremic pruritus in patients on hemodialysis and peritoneal dialysis.Material/MethodsWe included 197 patients with end-stage renal disease: 54 on continuous ambulatory peritoneal dialysis and 143 on hemodialysis. Substance P, calcium, phosphorus, iron, ferritin, CRP, albumin, hemoglobin, Ca × P product, and iPTH level were determined in all participants. The correlation between these parameters and self-reported itching was evaluated in patients on hemodialysis in comparison with peritoneal dialysis patients.ResultsThe incidence of itching was similar in hemodialysis and peritoneal dialysis patients. No differences in substance P level between the 2 groups were found. There was no correlation between substance P level and the incidence or intensity of pruritus in dialyzed patients.ConclusionsThis study demonstrates that substance P does not play any important role in pruritus in hemodialysed and peritoneal dialyzed patients. However, further studies are necessary to assess the exact role of neuropeptides in uremic pruritus.

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Section: Discussionsupporting

confidence: 64%

Substance P and intensity of pruritus in hemodialysis and peritoneal dialysis patients

et al. 2013

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“…The present study also found that DMN patients with HD had physical problems related to the eyes, blood pressure, cardiovascular disease, skin, and nails, and problems in everyday life such as shopping, mobility, dressing oneself, and job; these were not statistically observed among DMN patients without HD. Indeed, these HD-associated physical symptoms [23,24] and social activities and participation [4] were previously reported in individual studies. In short, these physical and social problems might be invisible to health professionals unless they deliberately ask their patients about possible problems they might be experiencing.…”

Section: Discussionmentioning

confidence: 92%

Identification of physical and psychosocial problems associated with diabetic nephropathy using the International Classification of Functioning, Disability and Health Core Set for Diabetes Mellitus

et al. 2015

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“…Multiple comorbidities have been associated with an increased risk of severe itch, including concurrent cardiovascular disease, congestive cardiac failure, lung disease, liver disease and neurological disease [ 3 , 16 ]. Diabetes mellitus is also reported to be associated with worse itch, with poor glycaemic control and a higherhaemoglobin A1c correlating with greater symptom burden [ 29 ]. However, the converse was seen in the GEHIS study, with a lower prevalence of itch in diabetic patients [ 28 ].…”

Section: Potential Risk Factors For Ckd-ap In Dialysis Patientsmentioning

confidence: 99%

Epidemiology and burden of chronic kidney disease-associated pruritus

Kim

Pollock

2021

Clinical Kidney Journal

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Chronic kidney disease–associated pruritus (CKD-aP) is a common, yet underrecognized condition in patients with CKD and end-stage kidney disease (ESKD). Real-world observational studies indicate that CKD-aP affects up to 80% of ESKD patients undergoing haemodialysis (HD), with ∼40% experiencing moderate to severe itch. CKD-aP can negatively impact patients’ mental and physical health-related quality of life (HRQoL) and is also associated with sleep disturbance and depression. Several studies have found that CKD-aP is a predictor of adverse medical outcomes, including an increased risk of hospitalizations and mortality. In this article we review the literature relating to the epidemiology of CKD-aP to describe its prevalence across the treatment spectrum of CKD (non-dialysis, HD, peritoneal dialysis and transplant recipients) and to summarize potential risk factors associated with its development. We also review key data from studies that have evaluated the impact of CKD-aP on HRQoL and medical outcomes.

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HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Cited by 18 publications

References 39 publications

Substance P and intensity of pruritus in hemodialysis and peritoneal dialysis patients

Substance P and intensity of pruritus in hemodialysis and peritoneal dialysis patients

Identification of physical and psychosocial problems associated with diabetic nephropathy using the International Classification of Functioning, Disability and Health Core Set for Diabetes Mellitus

Epidemiology and burden of chronic kidney disease-associated pruritus

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