Urbanization, ambient air pollution, and prevalence of chronic kidney disease: A nationwide cross-sectional study

Liang, Ze; Wang, Wanzhou; Wang, Yueyao; Ma, Lin; Liang, Chenyu; Li, Pengfei; Yang, Chao; Wei, Feili; Li, Shuangcheng; Zhang, Luxia

doi:10.1016/j.envint.2021.106752

Cited by 46 publications

(21 citation statements)

References 70 publications

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“…Study period: 2007 – 2009 An IQR increment of PM 2.5 exposure and/or PM 2.5 absorbance indicated no association(s) with a lower eGFR or CKD. Liang et al (2021)[ 45 ] (nation-wide cross-sectional study) The median (IQR) PM 2.5 concentration amounted to 44.63 (18.65) µg/m³. The median exceeded by far the standard air quality guidelines set by the WHO.…”

Section: Resultsmentioning

confidence: 99%

“…Of all included studies, 19 studies [ 22 – 26 , 31 , 33 – 45 , 47 – 53 , 56 , 58 ] had PM 2.5 exposure levels that exceeded the old 2006 WHO air quality guidelines for ambient PM 2.5 , namely the annual mean (10 µg/m³) or the 24-hour mean (25 µg/m³) [ 60 ], of which 7 studies had PM 2.5 exposure levels ranging from below the guideline to exceeding the pre-set guidelines [ 33 , 34 , 36 , 44 , 51 , 56 , 58 ]. Only 5 studies had a mean PM 2.5 exposure level below the 2006 WHO air quality guidelines [ 27 , 54 , 55 , 57 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

“…In this nation-wide cross-sectional study (n = 47,086), a 10 µg/m³ increment in PM 2.5 was shown to be significantly associated with increased odds for CKD (OR = 1.24, 95% CI 1.14 to 1.35) at 1- to 4-year moving averages of PM 2.5 exposure (p < 0.001). Furthermore, stronger increased odds for CKD was demonstrated in rural areas (OR = 1.51, 95% CI 1.29 to 1.78) compared to urban areas (OR = 0.92, 95% CI 0.79 to 1.07) per increase of 10 µg/m³ PM 2.5 at 2-year moving average (p interaction < 0.001) [ 45 ]. In the Veterans Affair Normative Aging cohort study by Gao et al [ 27 ], for each 4.09 µg/m³ increment in short-term (28-day) PM 2.5 concentration, an increased odds for CKD (OR = 1.1399, 95% CI -0.0099 to 0.2718) was observed, albeit non-significant (p > 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…Ran et al [ 40 ] suggested that CKD patients enrolled in their study could be in the moderate to high stages, as symptoms were severe enough to be hospitalized. Furthermore, not every study addressed significant drivers of the development and progression of CKD, such as hypertension [ 22 , 36 – 40 , 43 – 49 , 51 ], diabetes [ 22 , 36 – 40 , 43 – 48 , 51 ], and cardiovascular disease [ 22 , 39 , 44 , 45 , 47 , 48 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

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Adverse Effects of fine particulate matter on human kidney functioning: a systematic review

et al. 2022

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Background Ambient fine particulate matter (PM < 2.5 μm, PM2.5) is gaining increasing attention as an environmental risk factor for health. The kidneys are considered a particularly vulnerable target to the toxic effects that PM2.5 exerts. Alteration of kidney function may lead to a disrupted homeostasis, affecting disparate tissues in the body. This review intends to summarize all relevant knowledge published between January 2000 and December 2021 on the effects of ambient PM2.5 and the adverse effects on kidney function in adults (≥ 18 years). Results and Discussion Studies published in peer-reviewed journals, written in English, regarding the effects of PM2.5 on kidney function and the development and/or exacerbation of kidney disease(s) were included. Of the 587 nonduplicate studies evaluated, 40 were included, comprising of studies on healthy or diagnosed with pre-existing disease (sub)populations. Most of the studies were cohort studies (n = 27), followed by 10 cross-sectional, 1 ecological and 2 time-series studies. One longitudinal study was considered intermediate risk of bias, the other included studies were considered low risk of bias. A large portion of the studies (n = 36) showed that PM2.5 exposure worsened kidney outcome(s) investigated; however, some studies show contradictory results. Measurement of the estimated glomerular filtration rate, for instance, was found to be positively associated (n = 8) as well as negatively associated (n = 4) with PM2.5. Limitations and Conclusion The main limitations of the included studies include residual confounding (e.g., smoking) and lack of individual exposure levels. The majority of included studies focused on specific subpopulations, which may limit generalizability. Evidence of the detrimental effects that ambient PM2.5 may exert on kidney function is emerging. However, further investigations are required to determine how and to what extent air pollution, specifically PM2.5, exerts adverse effects on the kidney and alters its function. Registration The systematic review protocol was submitted and published by the International Prospective Register of Systematic Reviews (PROSPERO; CRD42020175615).

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adverse Effects of fine particulate matter on human kidney functioning: a systematic review

et al. 2022

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“…[285][286][287][288][289] Research continues to elucidate synergistic effects between genetics and other environmental contaminants (i.e., industrial chemicals) that can increase the risk for CKD or accelerate progression. [290][291][292][293][294] CKD is characterized by a gradual loss of kidney function over time, and can increase risk of high blood pressure, heart disease, stroke, and premature death. [230,294,295] CKD can also be caused by diabetes and high blood pressure.…”

Section: Treating Other Chronic Diseases With Hydrogels and Hydrogel ...mentioning

confidence: 99%

Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment

Gutiérrez

Frazar

Klaus

et al. 2021

Adv Healthcare Materials

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Humans are constantly exposed to exogenous chemicals throughout their life, which can lead to a multitude of negative health impacts. Advanced materials can play a key role in preventing or mitigating these impacts through a wide variety of applications. The tunable properties of hydrogels and hydrogel nanocomposites (e.g., swelling behavior, biocompatibility, stimuli responsiveness, functionality, etc.) have deemed them ideal platforms for removal of environmental contaminants, detoxification, and reduction of body burden from exogenous chemical exposures for prevention of disease initiation, and advanced treatment of chronic diseases, including cancer, diabetes, and cardiovascular disease. In this review, three main junctures where the use of hydrogel and hydrogel nanocomposite materials can intervene to positively impact human health are highlighted: 1) preventing exposures to environmental contaminants, 2) prophylactic treatments to prevent chronic disease initiation, and 3) treating chronic diseases after they have developed.

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Association of air pollution and risk of chronic kidney disease: A systematic review and meta‐analysis

Xu,

Jia,

Lin

et al. 2023

J Biochem & Molecular Tox

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Although epidemiological studies have evaluated the association between ambient air pollution and chronic kidney disease (CKD), the results remain mixed. To clarify the nature of the association, we conducted a comprehensive systematic review and meta‐analysis to assess the global relationship between air pollution and CKD. The Web of Science, PubMed, Embase and Cochrane Library databases systematically were searched for studies published up to July 2023 and included 32 studies that met specific criteria. The random effects model was used to derive overall risk estimates for each pollutant. The meta‐analysis estimated odds ratio (ORs) of risk for CKD were 1.42 (95% confidence interval [CI]: 1.31–1.54) for each 10 μg/m3 increase in PM2.5; 1.20 (95% CI: 1.14–1.26) for each 10 μg/m3 increase in PM10; 1.07 (95% CI: 1.05–1.09) for each 10 μg/m3 increase in NO2; 1.03 (95% CI: 1.02–1.03) for each 10 μg/m3 increase in NOX; 1.07 (95% CI: 1.01–1.12) for each 1 ppb increase in SO2; 1.03 (95% CI: 1.00–1.05) for each 0.1 ppm increase in CO. Subgroup analysis showed that this effect varied by gender ratio, age, study design, exposure assessment method, and income level. Furthermore, PM2.5, PM10, and NO2 had negative effects on CKD even within the World Health Organization‐recommended acceptable concentrations. Our results further confirmed the adverse effect of air pollution on the risk of CKD. These findings can contribute to enhance the awareness of the importance of reducing air pollution among public health officials and policymakers.

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Urbanization, ambient air pollution, and prevalence of chronic kidney disease: A nationwide cross-sectional study

Cited by 46 publications

References 70 publications

Adverse Effects of fine particulate matter on human kidney functioning: a systematic review

Adverse Effects of fine particulate matter on human kidney functioning: a systematic review

Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment

Association of air pollution and risk of chronic kidney disease: A systematic review and meta‐analysis

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