Urban Air Pollution Enhances the Formation of Urethane-Induced Lung Tumors in Mice

Air Pollution and Outpatient Treatment and Hospital Admissions for Respiratory Diseases in Children in Southeast Region of Brazil

“…Rumel and colleagues (1993) 46 studied the occurrence of visits to emergency services for acute myocardial infarction and found an association with levels of carbon monoxide (CO) and ambient temperature. In an experimental study, Reymão and colleagues (1997) 47 suggest that air pollution may facilitate the formation of certain types of lung cancer in rats. However, the ecological character of some these studies, the lack of specificity regarding the age groups most susceptible and the various health effects, the short period of investigation (usually one year), which hampers control of temporal trends and the short careful control of meteorological variables, among other issues, prevented a better assessment of the effects of air pollution on health in the Brazilian context.…”

La pollution de l’air ambiant augmente le risque de cancer

“…Néanmoins, le rôle carcinogène de l'air ambiant a été confirmé chez des personnes qui n'ont jamais fumé et on estime que le nombre de décès par cancer du poumon lié à l'air ambiant atteignait 230 000 dans le monde en 2010, ce qui est considérable. Enfin, une augmentation de la fréquence des adénomes du poumon a été confirmée chez les souris recevant de l'uréthane et exposées au trafic routier intense de la région de Sao Paulo au Brésil [3]. Une autre tumeur, le cancer de la vessie, a été liée aux facteurs carcinogènes de l'air ambiant, dans des cas particuliers chez les personnes très exposées aux vapeurs issues d'un moteur diesel ou à la combustion du charbon et du bois.…”

Ação dos compostos antioxidantes na redução do estresse oxidativo em modelo experimental de câncer de pulmão: estudo do pequi (Caryocar brasilense camb)

“…Recentemente, tem se utilizado um modelo experimental em camundongos no qual tumores pulmonares são induzidos por uretana (Reymão et al, 1997;Cury et al, 2000;. A uretana (carbamato de etila) é um composto com comprovada ação genotóxica tanto in vitro como in vivo, levando portanto ao estresse oxidativo (Mirvish, 1968).…”

“…Os adenocarcinomas resultantes constituem um excelente modelo de estudo da carcinogênese pulmonar (Reymão et al, 1997;.…”

“…Lung carcinogenesis was induced in mice with 2 intra-peritoneal injections of urethane, a chemical carcinogen, in the concentration of 1.5 g/kg/dose [28] . The use of urethane for the induction of this type of cancer is a simple and widely known experimental model of lung cancer [28][29][30][31][32][33] . The optimal dose of pequi oil and pequi extract used in this work was established by two conducting pilot studies and based in published data that worked with these compounds [10][11][12][13] .…”